Rectal artesunate suppositories for the pre-referral treatment of suspected severe malaria [PDF]
PLoS Medicine, 2023 In this Policy Forum article, James A. Watson and colleagues discuss recent guidelines relating to pre-referral treatment of suspected severe malaria with rectal artesunate suppositories in remote areas.
James A Watson +2 more
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Health worker compliance with severe malaria treatment guidelines in the context of implementing pre-referral rectal artesunate in the Democratic Republic of the Congo, Nigeria, and Uganda: An operational study [PDF]
PLoS Medicine, 2023 BackgroundFor a full treatment course of severe malaria, community-administered pre-referral rectal artesunate (RAS) should be completed by post-referral treatment consisting of an injectable antimalarial and oral artemisinin-based combination therapy ...
Aita Signorell +2 more
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The CARAMAL study could not assess the effectiveness of rectal artesunate in treating suspected severe malaria [PDF]
BMC Medicine, 2023 CARAMAL was a large observational study which recorded mortality in children with suspected severe malaria before and after the roll-out of rectal artesunate in Nigeria, Uganda and the Democratic Republic of the Congo.
James A. Watson +2 more
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Pre-referral rectal artesunate is no “magic bullet” in weak health systems [PDF]
BMC Medicine, 2023 Severe malaria is a potentially fatal condition that requires urgent treatment. In a clinical trial, a sub-group of children treated with rectal artesunate (RAS) before being referred to a health facility had an increased chance of survival.
Manuel W. Hetzel +12 more
doaj +2 more sources
Community access to rectal artesunate for malaria (CARAMAL): A large-scale observational implementation study in the Democratic Republic of the Congo, Nigeria and Uganda. [PDF]
PLOS Global Public Health, 2022 The key to reducing malaria deaths in highly endemic areas is prompt access to quality case management. Given that many severe cases occur at peripheral level, rectal artesunate (RAS) in the form of suppositories was developed in the 1990s, allowing for ...
Christian Lengeler +25 more
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Acceptability of pre-referral rectal artesunate for severe malaria in children under 5 years by health workers and caregivers in the Democratic Republic of the Congo, Nigeria and Uganda [PDF]
Malaria Journal, 2022 Background For children below 6 years with suspected severe malaria attending a health care provider unable to provide parenteral malaria treatment, pre-referral rectal artesunate (RAS) is recommended by the World Health Organization to prevent death and
Phyllis Awor +18 more
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Population Pharmacokinetics of Artesunate and Dihydroartemisinin following Intra-Rectal Dosing of Artesunate in Malaria Patients [PDF]
PLoS Medicine, 2006 Intra-rectal artesunate has been developed as a potentially life-saving treatment of severe malaria in rural village settings where administration of parenteral antimalarial drugs is not possible.
Julie A Simpson +2 more
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Adherence to the referral advice after introduction of rectal artesunate for pre-referral treatment of severe malaria at the community level: a noninferiority trial in the Democratic Republic of the Congo [PDF]
Malaria Journal, 2019 Background The Democratic Republic of the Congo adopted the strategy of using, at the community level, a dose of rectal artesunate as a pre-referral treatment for severe malaria amongst children under 5 years who could not quickly reach a health care ...
Patrick M. Mvumbi +4 more
doaj +2 more sources
Effectiveness of rectal artesunate as pre-referral treatment for severe malaria in children under 5 years of age: a multi-country observational study [PDF]
BMC Medicine, 2022 Background To prevent child deaths from severe malaria, early parenteral treatment is essential. Yet, in remote rural areas, accessing facilities offering parenteral antimalarials may be difficult.
Manuel W. Hetzel +26 more
doaj +2 more sources
Preparations of Rectal Suppositories Containing Artesunate
Pharmaceutics, 2020 Rectal artesunate suppositories are a useful option for pre-referral treatment of severe malaria, specifically in children under 6 years of age in remote malaria-endemic areas.
Hyunah Cho
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