Results 41 to 50 of about 865 (113)

Phytochemicals and Regulation of NF-kB in Inflammatory Bowel Diseases: An Overview of In Vitro and In Vivo Effects

Metabolites, 2023
Inflammatory bowel diseases (IBD) are chronic relapsing idiopathic inflammatory conditions affecting the gastrointestinal tract. They are mainly represented by two forms, ulcerative colitis (UC) and Crohn’s disease (CD).
Lucas Fornari Laurindo, Ana Rita de Oliveira dos Santos, Antonelly Cassio Alves de Carvalho, Marcelo Dib Bechara, Elen Landgraf Guiguer, Ricardo de Alvares Goulart, Renata Vargas Sinatora, Adriano Cressoni Araújo, Sandra Maria Barbalho   +8 more
doaj   +1 more source

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, Volume 7, Issue 1, January 2026.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

A qualitative study to identify community structures for management of severe malaria: a basis for introducing rectal artesunate in the under five years children in Nakonde District of Zambia

BMC Public Health, 2005
Background Malaria is a serious illness among children aged 5 years and below in Zambia, which carries with it many adverse effects including anemia and high parasites exposure that lead to infant and childhood mortality.
Tuba Mary, Kaona Frederick AD
doaj   +1 more source

High‐Dose Ascorbic Acid Combined With Dihydroartemisinin Inhibits Lung Adenocarcinoma Malignancy by Inducing Ferroptosis via SLC7A11/GPX4 Pathway

Journal of Cellular and Molecular Medicine, Volume 29, Issue 24, December 2025.
ABSTRACT This study evaluated the effect of ascorbic acid (AA) combined with dihydroartemisinin (DHA) in lung adenocarcinoma (LUAD) and the underlying mechanisms to determine whether this combination therapy provides a new therapeutic direction for the treatment of LUAD. The CCK‐8, colony formation and transwell assays were used to assess the vitality,
Lan Li, Fei Lu, Sisong Shu, Xiao Jiang, Han Lu, Ke Cao, Zhengting Chen, Jingyan Gao, Mengyuan Liu, Li Chang, Wenhui Li   +10 more
wiley   +1 more source

Oral Administration of Piperine as Curative and Prophylaxis Reduces Parasitaemia in Plasmodium berghei ANKA-Infected Mice

Journal of Tropical Medicine, 2022
Malaria remains a public health problem and a leading cause of death worldwide. Consequently, the discovery of novel agents, including substances from medicinal plants, is urgently needed. Piper nigrum has long been used by the community in the treatment
Shafia Khairani, Nisa Fauziah, Hesti Lina Wiraswati, Ramdan Panigoro, Endang Yuni Setyowati, Afiat Berbudi   +5 more
doaj   +1 more source

Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization

Advanced Science, Volume 12, Issue 19, May 22, 2025.
This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao, Yule Yong, Zhaohui Zheng, Kui Zhang, Wei Li, Jiayi Liu, Siyi Zhou, Juan‐juan Qin, Haoyang Sun, Yatao Wang, Xianghui Fu, Xing Luo, Siyu Chen, Zhi‐Gang She, Jingjing Cai, Ping Zhu   +15 more
wiley   +1 more source

Global emergency medicine: A scoping review of the literature from 2023

Academic Emergency Medicine, Volume 32, Issue 5, Page 553-569, May 2025.
Abstract Objective The Global Emergency Medicine Literature Review (GEMLR) highlights the highest‐quality research addressing emergency care in resource‐limited settings (ECRLS). This 18th edition reviews global emergency medicine (GEM) literature published during 2023.
Braden J. Hexom, Nana Serwaa A. Quao, N. Shakira Bandolin, Joseph Bonney, Morgan C. Broccoli, Amanda Collier, Nanaba A. Dawson‐Amoah, Jonathan Dyal, Vinay Kampalath, J. Austin Lee, Chris A. Rees, Gabriel Lucca de Oliveira Salvador, Jonathan M. Strong, Sean M. Kivlehan, on behalf of the Global Emergency Medicine Literature Review (GEMLR) Group, Zainab Ahmed, Kimonia Bih Awanchiri, N. Shakira Bandolin, Emily Bartlett, Nidhi Bhaskar, Corey B. Bills, Joseph Bonney, Morgan C. Broccoli, Whitney K. Bryant, Agatha Brzezinski, Jonathan Chan, Emily Chien, Joseph D. Ciano, Cassandra Clay, Emily Cloessner, Amanda Collier, Emma Cortes, Nanaba A. Dawson‐Amoah, Jonathan W. Dyal, Stephanie Chow Garbern, Reid Haflich, Mohamed F. Hassan, Alison S. Hayward, Braden J. Hexom, Keanoo C. Hill, Anneka Hooft, Jennifer E. Jones, Vinay N. Kampalath, Elizabeth M Keating, Sean M. Kivlehan, Colleen E. Laurence, Joseph Leanza, J. Austin Lee, Gideon Loevinsohn, Rmaah Memon, Mwanja Moses, Dana Naamani, Benjamin D. Nicholson, Hannah Ofosua Owusu, Gerard M. O’Reilly, Mayur Patel, Nana Serwaa A. Quao, Chris A. Rees, Pryanka Relan, Charlotte M. Roy, Megan M. Rybarczyk, Gabriel Lucca de Oliveira Salvador, Anand Selvam, Julia R. Schiff, Jessica Schmidt, Megan L. Schultz, Erin F Shufflebarger, Branden J. Skarpiak, Jonathan M. Strong, Janet Jebichii Sugut, Fadila Tekka, Alex H. Wang, W. Tyler Winders, Tal Berkowitz, Vijaya Arun Kumar, Mallika Manyapu, Daniel Roberts   +76 more
wiley   +1 more source

Use of population pharmacokinetic‐pharmacodynamic modelling to inform antimalarial dose optimization in infants

British Journal of Clinical Pharmacology, Volume 91, Issue 4, Page 968-980, April 2025.
Infants bear a significant malaria burden but are usually excluded from participating in early dose optimization studies that inform dosing regimens of antimalarial therapy. Unlike older children, infants' exclusion from early‐phase trials has resulted in limited evidence to guide accurate dosing of antimalarial treatment for uncomplicated malaria or ...
Clifford G. Banda, Joel Tarning, Karen I. Barnes   +2 more
wiley   +1 more source

Impact of combining intermittent preventive treatment with home management of malaria in children less than 10 years in a rural area of Senegal: a cluster randomized trial

Malaria Journal, 2011
Background Current malaria control strategies recommend (i) early case detection using rapid diagnostic tests (RDT) and treatment with artemisinin combination therapy (ACT), (ii) pre-referral rectal artesunate, (iii) intermittent preventive treatment and
Tine Roger CK, Faye Babacar, Ndour Cheikh T, Ndiaye Jean L, Ndiaye Magatte, Bassene Charlemagne, Magnussen Pascal, Bygbjerg Ib C, Sylla Khadim, Ndour Jacques D, Gaye Oumar   +10 more
doaj   +1 more source

Effect of Allicin and Artesunate Combination Treatment on Experimental Mice Infected with Plasmodium berghei

Veterinary Medicine International, 2022
Malaria is still a significant health problem in endemic countries and increases Plasmodium resistance to the available antimalarial drugs. Hence, this study aimed to investigate the antimalarial activity of allicin and its combination with artesunate ...
Sakaewan Ounjaijean, Voravuth Somsak
doaj   +1 more source