Results 51 to 60 of about 865 (113)

The Therapeutic Effects of Bioactive Compounds on Colorectal Cancer via PI3K/Akt/mTOR Signaling Pathway: A Critical Review

Food Science &Nutrition, Volume 12, Issue 12, Page 9951-9973, December 2024.
This study discussed the therapeutic capacity of various polyphenols, terpenoids, and alkaloids on CRC via the PI3K/Akt/mTOR pathway. Each bioactive component causes various physiological processes, such as triggering free radical production, disruption of mitochondrial membrane potential, cell cycle arrest, inhibition of CRC stem cell migration ...
Kübra Demir, Rana Turgut, Selcen Şentürk, Handan Işıklar, Elif Günalan   +4 more
wiley   +1 more source

Caregivers’ compliance with referral advice: evidence from two studies introducing mRDTs into community case management of malaria in Uganda

BMC Health Services Research, 2018
Background Several malaria endemic countries have implemented community health worker (CHW) programmes to increase access to populations underserved by health care.
Sham Lal, Richard Ndyomugenyi, Lucy Paintain, Neal D. Alexander, Kristian S. Hansen, Pascal Magnussen, Daniel Chandramohan, Siân E. Clarke   +7 more
doaj   +1 more source

Potential of extracellular vesicles in the pathogenesis, diagnosis and therapy for parasitic diseases

Journal of Extracellular Vesicles, Volume 13, Issue 8, August 2024.
Abstract Parasitic diseases have a significant impact on human and animal health, representing a major hazard to the public and causing economic and health damage worldwide. Extracellular vesicles (EVs) have long been recognized as diagnostic and therapeutic tools but are now also known to be implicated in the natural history of parasitic diseases and ...
Ana Acacia Sá Pinheiro, Ana Claudia Torrecilhas, Bruno Solano de Freitas Souza, Fernanda Ferreira Cruz, Herbert Leonel de Matos Guedes, Tadeu Diniz Ramos, Miqueias Lopes‐Pacheco, Celso Caruso‐Neves, Patricia R. M. Rocco   +8 more
wiley   +1 more source

Role of traditional healers in the management of severe malaria among children below five years of age: the case of Kilosa and Handeni Districts, Tanzania

Malaria Journal, 2006
Background The current malaria control strategy of WHO centres on early diagnosis and prompt treatment using effective drugs. Children with severe malaria are often brought late to health facilities and traditional health practitioners are said to be the
Kitua Andrew Y, Mhame Paulo, Malebo Hamisi M, Makundi Emmanuel A, Warsame Marian   +4 more
doaj   +1 more source

Recognition, perceptions and treatment practices for severe malaria in rural Tanzania: implications for accessing rectal artesunate as a pre-referral.

PLoS ONE, 2007
ObjectivesPreparatory to a community trial investigating how best to deliver rectal artesunate as pre-referral treatment for severe malaria; local understanding, perceptions of signs/symptoms of severe malaria and treatment-seeking patterns for and ...
Marian Warsame, Omari Kimbute, Zena Machinda, Patricia Ruddy, Majaha Melkisedick, Thomas Peto, Isabela Ribeiro, Andrew Kitua, Goran Tomson, Melba Gomes   +9 more
doaj   +1 more source

Assessment of availability and challenges of WHO recommended priority life-saving medicines for under five-year children in primary public health facilities of Amhara region

BMC Pediatrics, 2023
Background The world health organization (WHO) priority lifesaving medicines are medicines recommended for the prevention and treatment of leading causes of under-five morbidity and mortality.
Mastewal Ezezew, Adane Yehualaw, Desalegn Getnet Demsie   +2 more
doaj   +1 more source

Programming a Ferroptosis‐to‐Apoptosis Transition Landscape Revealed Ferroptosis Biomarkers and Repressors for Cancer Therapy

Advanced Science, Volume 11, Issue 17, May 8, 2024.
Transcriptomic, metabolomics, mechanistic, and computational analyses of programmed ferroptosis‐to‐apoptosis transition landscape identified ferroptosis selective biomarkers, revealed ferroptosis repressors as potential targets for breast cancer therapy, and highlighted ferroptosis‐toapoptosis molecular switches, including the PE/PC lipidomic shift ...
Yaron Vinik, Avi Maimon, Vinay Dubey, Harsha Raj, Ifat Abramovitch, Sergey Malitsky, Maxim Itkin, Avi Ma'ayan, Frank Westermann, Eyal Gottlieb, Eytan Ruppin, Sima Lev   +11 more
wiley   +1 more source

Current Trends of Raman Spectroscopy in Clinic Settings: Opportunities and Challenges

Advanced Science, Volume 11, Issue 7, February 16, 2024.
The paper systematically demonstrates the status and trends in the application development of Raman combined with machine learning, nanoparticles, and probes in typical clinical diseases. The focus is to explore the limitations and sources of errors in traditional techniques, providing a comprehensive showcase of the typical research outcomes of Raman ...
Yumei Wang, Liuru Fang, Yuhua Wang, Zuzhao Xiong   +3 more
wiley   +1 more source

Availability and affordability of priority life-saving medicines for under-five children in health facilities of Tigray region, northern Ethiopia

BMC Pregnancy and Childbirth, 2018
Background In developing countries, child health outcomes are influenced by the non-availability of priority life-saving medicines at public sector health facilities and non-affordability of medicines at private medicine outlets.
Solomon Abrha, Ebisa Tadesse, Tesfay Mehari Atey, Fantahun Molla, Wondim Melkam, Birhanetensay Masresha, Solomon Gashaw, Abrham Wondimu   +7 more
doaj   +1 more source

Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration

Malaria Journal, 2011
Artesunate (AS) is a clinically versatile artemisinin derivative utilized for the treatment of mild to severe malaria infection. Given the therapeutic significance of AS and the necessity of appropriate AS dosing, substantial research has been performed ...
Shin Chang-Sik, Jung Donald, Borghini-Fuhrer Isabelle, Duparc Stephan, Morris Carrie A, Fleckenstein Lawrence   +5 more
doaj   +1 more source