Results 31 to 40 of about 865 (113)

Health worker and policy-maker perspectives on use of intramuscular artesunate for pre-referral and definitive treatment of severe malaria at health posts in Ethiopia

Malaria Journal, 2016
Background The World Health Organization (WHO) recommends injectable artesunate given either intravenously or by the intramuscular route for definitive treatment for severe malaria and recommends a single intramuscular dose of intramuscular artesunate or
Takele Kefyalew, Zelalem Kebede, Dawit Getachew, David Mukanga, Tessema Awano, Agonafer Tekalegne, Esey Batisso, Wasihun Edossa, Emebet Mekonnen, James Tibenderana, Ebenezer Sheshi Baba, Constance Shumba, Joaniter I. Nankabirwa, Prudence Hamade   +13 more
doaj   +1 more source

Outcomes reported in trials of treatments for severe malaria: The need for a core outcome set

Tropical Medicine &International Health, Volume 27, Issue 9, Page 767-775, September 2022., 2022
Abstract Objectives Malaria is one of the most important parasitic infectious diseases worldwide. Despite the scale‐up of effective antimalarials, mortality rates from severe malaria (SM) remain significantly high; thus, numerous trials are investigating both antimalarials and adjunctive therapy.
Lamprini Lampro, Elizabeth C. George
wiley   +1 more source

Key factors predicting suspected severe malaria case management and health outcomes: an operational study in the Democratic Republic of the Congo

Malaria Journal, 2022
Background Evidence suggests that pre-referral Rectal Artesunate (RAS) can be a life-saving intervention for severe malaria in remote settings in Africa. Recognition of danger signs indicative of severe malaria is critical for prompt and appropriate case
Jean Okitawutshu, Aita Signorell, Jean-Claude Kalenga, Eric Mukomena, Giulia Delvento, Christian Burri, Fatou Mwaluke, Valentina Buj, Moulaye Sangare, Sylvie Luketa, Nina Brunner, Tristan Lee, Manuel Hetzel, Christian Lengeler, Antoinette Tshefu   +14 more
doaj   +1 more source

Understanding caretakers' dilemma in deciding whether or not to adhere with referral advice after pre-referral treatment with rectal artesunate

Malaria Journal, 2010
Background Malaria kills. A single rectal dose of artesunate before referral can reduce mortality and prevent permanent disability. However, the success of this intervention depends on caretakers' adherence to referral advice for follow-up care.
Gomes Melba F, Premji Zul, Warsame Marian, Kakoko Deodatus C, Simba Daudi O, Tomson Goran, Johansson Eva   +6 more
doaj   +1 more source

Assessing caregivers’ perceptions of treatment-seeking for suspected severe malaria in the Democratic Republic of the Congo

Malaria Journal, 2023
Background Malaria remains a major public health issue in the Democratic Republic of the Congo (DRC), accounting for 44% deaths among outpatient visits in children 
Jean Okitawutshu, Antoinette Tshefu, Jean-Claude Kalenga, Giulia Delvento, Christian Burri, Manuel W. Hetzel, Christian Lengeler, Aita Signorell   +7 more
doaj   +1 more source

Cost effectiveness of pre-referral antimalarial treatment in severe malaria among children in sub-Saharan Africa

Cost Effectiveness and Resource Allocation, 2017
Background In 2013, 78% of malaria deaths occurred in children aged 5 years and below, in sub-Saharan Africa. Treatment of severe malaria requires a health facility with inpatient care.
Vivian Rakuomi, Faith Okalebo, Stanley Ndwigah, Levi Mbugua   +3 more
doaj   +1 more source

Artesunate: The Best Drug in the Treatment of Severe and Complicated Malaria

Pharmaceuticals, 2010
This review summarizes progress in treating severe and complicated malaria, which are global problems, claiming at least one million lives annually, and have been accompanied by advances in our understanding of the pathogenesis of severe malaria ...
Qigui Li, Peter Weina
doaj   +1 more source

Systematic review of artesunate pharmacokinetics: Implication for treatment of resistant malaria

International Journal of Infectious Diseases, 2019
Background: Artesunate (ART) is an artemisinin derivative used as monotherapy for the treatment of severe malaria and in combination with a partner drug for non-severe malaria.
Yobouet Ines Kouakou, Michel Tod, Gilles Leboucher, Adeline Lavoignat, Guillaume Bonnot, Anne-Lise Bienvenu, Stephane Picot   +6 more
doaj   +1 more source

Knowledge and acceptability of the rectal treatment route in Laos and its application for pre-referral emergency malaria treatment

Malaria Journal, 2010
Background Rectal artesunate has been shown to reduce death and disability from severe malaria caused by delays in reaching facilities capable of providing appropriate treatment. Acceptability of this mode of drug delivery in Laos is not known.
Ashley Elizabeth A, Meimei Yang, Franchard Thierry, Inthavilay Southisouk, Barennes Hubert   +4 more
doaj   +1 more source

Priority medicines for maternal and child health: a global survey of national essential medicines lists. [PDF]

PLoS ONE, 2012
BackgroundIn April 2011, the World Health Organization (WHO) published a list of "priority medicines" for maternal and child health based on 1) the global burden of disease and 2) evidence of efficacy and safety.
Suzanne Hill, Annie Yang, Lisa Bero
doaj   +1 more source