Results 61 to 70 of about 2,947,352 (175)

La Place De L´école Dans Le Système De La Sélection Des Jeunes Talents Sportifs

open access: yesمجلة العلوم و التكنولوجية للنشاطات البدنية و الرياضية, 2009
Les réussites des sportifs dans les compétions du haut niveau ne sont pas des occurrences, mais elles sont les résultats d´un long travail systématique, orienté vers la découverte du talent sportif, son inspiration, son développement avec le débouché ...
Antala Branislav, Sedláček Jaromír
doaj  

Low Latency Global Carbon Budget Reveals Late 2024 Carbon Losses and Contrasting Early 2025 Land Sink Recovery Signals

open access: yesAdvanced Science, EarlyView.
Low latency carbon budget estimates for July 2024–June 2025 combine atmospheric CO2 growth rates, fossil emissions, ocean uptake, DGVM land fluxes, and OCO‐2 inversions. The budget shows that late‐2024 land carbon losses dominate the annual anomaly, while early‐2025 recovery differs between bottom‐up models and top‐down inversions, especially in ...
Piyu Ke   +32 more
wiley   +1 more source

Rational Molecular Design to Improve Digital Polymer Readout in Aerolysin‐Based Nanopore Sequencing

open access: yesAngewandte Chemie, EarlyView.
Nanopore sensing holds significant yet underexplored potential for decoding synthetic digital polymers. In this study, we synthesized an extensive library of sequence‐defined poly(phosphodiester)s and evaluated their performance in aerolysin‐based sequencing. By systematically optimizing molecular parameters, we identified an ideal combination of coded
Zhaozheng Yang   +9 more
wiley   +2 more sources

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

open access: yesAdvanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka   +10 more
wiley   +1 more source

Chemical Synthesis and Functional Screening of an 800 000‐Member Library Using a Peptide‐Pairing Strategy

open access: yesAngewandte Chemie, EarlyView.
Chemical peptide synthesis allows the generation of structurally highly diverse compounds suited for ligand development, but current methods in parallel peptide synthesis limit the achievable library size to a few thousand. A strategy is presented based on combinatorial pairing of short peptides via disulfide linkage that enables the generation and ...
Anne Zarda   +5 more
wiley   +2 more sources

Beyond‐Classical Ferroelectric Metamaterials: 3D‐Printed Planar Lattices With Programmable Electro–Thermo–Mechanical Coupling

open access: yesAdvanced Science, EarlyView.
Planar ferroelectric lattices with rationally‐tailored topology and polarization achieve programmable piezoelectric and pyroelectric properties. Analytical modeling, homogenization, and experiments collectively demonstrate enhanced and tunable longitudinal, transverse, and shear piezoelectric responses, together with substantially improved ...
Jiahao Shi   +6 more
wiley   +1 more source

Distinct Molten‐Globule Conformations in an Interacting Protein Domain Resolved by 19F NMR of Fluoroproline Residues

open access: yesAngewandte Chemie, EarlyView.
Modifying the conformational ensemble of “molten‐globule” protein by the site‐specific incorporation of stereoisomeric 4‐fluoroproline residues modulated its binding affinity and aggregation behavior. 19F NMR spectroscopy enabled the detection of key interactions responsible for structural and dynamic changes. ABSTRACT Recently, the application of deep
Abir Ben Bouzayene   +5 more
wiley   +2 more sources

Entre sélection et visée inclusive : comment construire une école équitable ?

open access: yes, 2017
Entre sélection et visée inclusive : comment construire une école équitable
Ramel, Serge
core  

Efficient In‐Hardware Matrix–Vector Multiplication and Addition Exploiting Bilinearity of Schottky Barrier Transistors Processed on Industrial FDSOI

open access: yesAdvanced Electronic Materials, EarlyView.
ABSTRACT Machine learning and Artificial Intelligence (AI) tasks have stretched traditional hardware to its limits. In‐hardware computation is a novel approach that aims to run complex operations, such as matrix–vector multiplication, directly at the device level for increased efficiency.
Juan P. Martinez   +10 more
wiley   +1 more source

Le bonheur en salle de classe par temps de crise : rôle et contribution des contes littéraires

open access: yesRevista Investigações
Les crises sociales contemporaines nous incitent à trouver des manières d’y résister. Parmi les pistes possibles, nous nous demandons comment l’école et la littérature pourraient contribuer à former des êtres humains véritablement heureux.
Simone Pires Barbosa Aubin
doaj   +1 more source

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