Results 61 to 70 of about 60,726,704 (248)
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
LA FORMACIÓN DE LOS ENTRENADORES DE JÓVENES FUTBOLISTAS [The training of young footballers’ coaches]
E-balonmano.com: Revista de Ciencias del Deporte, 2013 Este estudio analizó la formación inicial y permanente, así como las necesidades de formación de los entrenadores de jóvenes futbolistas de Andalucía.
Manuel Tomás Abad Robles +3 more
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Educação em Revista, 2008 Este trabalho aponta pressupostos para a pesquisa qualitativa em Educação Física, a partir de revisão de literatura, com base no referencial cultural.
Cinthia Lopes da Silva +2 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Les conditions de la non-éducation
, 2018 International audienceL'éducation est un droit de l'homme et, partout dans le monde, on constate que les hommes se trouvent dans des situations de non-éducation. S'agit-il seulement d'un échec des politiques d'éducation?
Olivier, Alain Patrick
core
Biblioinfo Base de dados sobre automação em bibliotecas (Informática documentária): 1986-1994
Ciência da Informação, 1994 A base de dados sobre automação em bibliotecas (Informática documentária) reúne 390 referências com resumo de periódicos brasileiros em biblioteconomia e ciência da informação, com o objetivo de colocar à disposição dos pesquisadores, estudantes e demais
Maria Lourdes Blatt Ohira
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