Results 91 to 100 of about 4,504,147 (220)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Disseny d'itineraris ambientals per [a] ús públic a Fornells de la Selva

, 2006
Aquest projecte tracta del disseny de diferents itineraris ambientals per a ús públic a Fornells de la selva, amb l'objectiu de recuperar i revaloritzar l'espai del meandre de l'Onyar per a ús públic i per a desenvolupar activitats d' educcació ...
Arasa Carot, Pau, Campíñez Salas, Pere
core   +1 more source

Real and complex singlet-scalar benchmarks with a vector-like down quark for $$B\rightarrow X_s\gamma $$ B → X s γ and $$B_s-\bar{B}_s$$ B s - B ¯ s mixing

European Physical Journal C: Particles and Fields
We study a simple extension of the Standard Model with a vector-like down-type quark D and a neutral singlet scalar $$\mathcal{S}=S_R,\Phi $$ S = S R , Φ . The scalar is considered in two forms, a real field $$S_R=S_R^\dagger $$ S R = S R † and a complex
Qazi Maaz Us Salam
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Traçant universos femenins amb paper maixé: la tradició de Takamatsu-hariko en les col·leccions del Museu Etnològic de Barcelona

Digithum, 2015
L’objectiu d’aquest article és traçar la biografia i mostrar l’ús social d’uns petits objectes de paper maixé pertanyents a la tradició de Takamatsu-hariko (Japó) que es conserven al Museu Etnològic de Barcelona.
Muriel Gómez Pradas
doaj   +2 more sources

Transmèdia Storytelling: explorant el seu ús en l'educació

Temes de Disseny, 2017
Les narratives transmèdia han transformat la manera en què s'imparteix la docència. És en aquest context on estudiants i professors poden expressar les seves experiències i les seves opinions utilitzant diverses eines de creació de continguts que ...
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Eduard Artells i la normativa: prescripció i ús

Estudis Romànics
L’article descriu la posició d’Eduard Artells en el model de llengua literària dels anys seixanta, com veia el paper del corrector i les polèmiques més importants que la seva manera de treballar li va comportar.
Alexis Llobet
doaj