α-Conotoxin TxIB Inhibits Development of Morphine-Induced Conditioned Place Preference in Mice via Blocking α6β2* Nicotinic Acetylcholine Receptors [PDF]
Frontiers in Pharmacology, 2021 Morphine, the main component of opium, is a commonly used analgesic in clinical practice, but its abuse potential limits its clinical application. Nicotinic acetylcholine receptors (nAChRs) in the mesolimbic circuitry play an important role in the ...
Xiaodan Li +6 more
doaj +2 more sources
Cysteine [2,4] Disulfide Bond as a New Modifiable Site of α-Conotoxin TxIB [PDF]
Marine Drugs, 2021 α-Conotoxin TxIB, a selective antagonist of α6/α3β2β3 nicotinic acetylcholine receptor, could be a potential therapeutic agent for addiction and Parkinson’s disease.
Baojian Zhang +8 more
doaj +2 more sources
α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal [PDF]
Frontiers in Pharmacology, 2022 Background and Purpose: Alcohol use disorder (AUD) is a serious public health issue and affects the lives of numerous people. Previous studies have shown a link between nicotinic acetylcholine receptors (nAChR) and alcohol addiction. However, the role of
Kailin Mao +8 more
doaj +2 more sources
Effects of Cyclization on Activity and Stability of α-Conotoxin TxIB [PDF]
Marine Drugs, 2020 α-Conotoxin TxIB specifically blocked α6/α3β2β3 acetylcholine receptors (nAChRs), and it could be a potential probe for studying addiction and other diseases related to α6/α3β2β3 nAChRs.
Xincan Li +5 more
doaj +2 more sources
Optimal Cleavage and Oxidative Folding of α-Conotoxin TxIB as a Therapeutic Candidate Peptide [PDF]
Marine Drugs, 2013 Alpha6beta2 nicotinic acetylcholine receptors (nAChRs) are potential therapeutic targets for the treatment of several neuropsychiatric diseases, including addiction and Parkinson’s disease.
Dongting Zhangsun +6 more
doaj +2 more sources
α-Conotoxin TxIB: A Uniquely Selective Ligand for α6/α3β2β3 Nicotinic Acetylcholine Receptor Attenuates Nicotine-Induced Conditioned Place Preference in Mice [PDF]
Marine Drugs, 2019 α-Conotoxin TxIB is a specific antagonist of α6/α3β2β3(α6β2*) nicotinic acetylcholine receptor (nAChR) with an IC50 of 28 nM.
Shen You +6 more
doaj +2 more sources
α-Conotoxin TxIB Reversed Nicotine-Induced Locomotor Sensitization and Nicotine-Enhanced Dopaminergic Activity in Mice [PDF]
Marine DrugsNicotine addiction is a serious global public health problem, so there is an urgent necessity to develop novel effective smoking cessation treatments with fewer adverse effects.
Weifeng Xu +7 more
doaj +2 more sources
Prey specificity of predatory venoms
Biological Reviews, Volume 99, Issue 6, Page 2253-2273, December 2024.ABSTRACT Venom represents a key adaptation of many venomous predators, allowing them to immobilise prey quickly through chemical rather than physical warfare. Evolutionary arms races between prey and a predator are believed to be the main factor influencing the potency and composition of predatory venoms.
Ondřej Michálek +2 more
wiley +1 more source
Molecular Determinants of Species Specificity of α-Conotoxin TxIB towards Rat and Human α6/α3β4 Nicotinic Acetylcholine Receptors. [PDF]
Int J Mol Sci, 2023 Xie T +9 more
europepmc +1 more source
Loop2 Size Modification Reveals Significant Impacts on the Potency of α-Conotoxin TxID. [PDF]
Mar Drugs, 2023 Dong J +7 more
europepmc +1 more source