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Hippocampal Metabolomics Reveal the Mechanism of α-Conotoxin [S9K]TxID Attenuating Nicotine Addiction. [PDF]

Mar Drugs
Wang M, Xu W, Wang H, Cui C, He R, Li X, Yu J, McIntosh JM, Zhangsun D, Luo S.   +9 more
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Globular and ribbon isomers of Conus geographus α-conotoxins antagonize human nicotinic acetylcholine receptors.

Biochemical Pharmacology, 2021
The short disulfide-rich α-conotoxins derived from the venom of Conus snails comprise a conserved CICII(m)CIII(n)CIV cysteine framework (m and n, number of amino acids) and the majority antagonize nicotinic acetylcholine receptors (nAChRs).
Han-Shen Tae, Bingmiao Gao, A. Jin, P. Alewood, David John Adams   +4 more
semanticscholar   +1 more source

Medicinal chemistry, pharmacology, and therapeutic potential of α-conotoxins antagonizing the α9α10 nicotinic acetylcholine receptor.

Pharmacology and Therapeutics, 2020
α-Conotoxins are disulfide-rich and well-structured peptides, most of which can block nicotinic acetylcholine receptors (nAChRs) with exquisite selectivity and potency. There are various nAChR subtypes, of which the α9α10 nAChR functions as a heteromeric
Xiao Li, Han-Shen Tae, Yan-yan Chu, Tao Jiang, D. Adams, Ri-lei Yu   +5 more
semanticscholar   +1 more source

Facile synthesis of sulfotyrosine-containing α-conotoxins.

Organic and biomolecular chemistry, 2020
α-Conotoxins (Ctx) can selectively target distinct subtypes of nicotinic acetylcholine receptors (nAChRs), which are closely related to a number of neurological diseases, and they have been considered as ideal probes and model peptide drugs ...
Changpeng Li, Chunmao He
semanticscholar   +1 more source

α-Conotoxins to explore the molecular, physiological and pathophysiological functions of neuronal nicotinic acetylcholine receptors.

Neuroscience Letters, 2017
The vast diversity of neuronal nicotinic acetylcholine subunits expressed in the central and peripheral nervous systems, as well as in non-neuronal tissues, constitutes a formidable challenge for researchers and clinicians to decipher the role of ...
Julien Giribaldi, S. Dutertre
semanticscholar   +1 more source

Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain.

Neuropharmacology, 2012
The large diversity of peptides from venomous creatures with high affinity for molecules involved in the development and maintenance of neuropathic pain has led to a surge in venom-derived analgesic research.
I. Napier, H. Klimis, B. Rycroft, A. Jin, P. Alewood, L. Motin, David John Adams, M. Christie   +7 more
semanticscholar   +1 more source

Dissecting oxidative folding of conotoxins using 3D structures of cysteine mutants predicted by AlphaFold 3: A case study of α-conotoxin RgIA, χ-conotoxin CMrVIA and ω-conotoxin MVIIA-Gly.

Toxicon
The ability of AlphaFold 3 to accurately predict the 3D structure of polypeptides has been explored to investigate the oxidative folding steps of conotoxins.
K. Radhakrishna, Patil Kanchan Rajshekhar, R. Arshitha, K. Patil, Shweta Dhannura, K. H. Gowd   +5 more
semanticscholar   +1 more source

Structures of muscle-type nicotinic acetylcholine receptor with α-conotoxins reveal determinants of receptor-subtype specificity

bioRxiv
Michael Capper, Oscar A. Shepperson, Charlie Holdship, Oliver J. Melling, Nicola Wade, Michael A Malone, Kirsty I M Arnott, Leonie Windeln, Steven Turner, C. Whitmore, Tiffany D. Morcom, Josephine A. Connah, C. Timperley, Jeremy G. Frey, A. C. Green, J. Essex, Jesko Köhnke, Andrew G. Jamieson   +17 more
semanticscholar   +1 more source

Interaction mechanism of α-conotoxins to the human α9α10 nAChR subtype

Toxicon, 2019
Ri-lei Yu, Han-Shen Tae, Nargis Tabassum, Tao Jiang, David John Adams   +4 more
semanticscholar   +1 more source

Discovery of a new subclass of α-conotoxins in the venom of Conus australis.

Toxicon, 2014
E. Lebbe, S. Peigneur, Mohitosh Maiti, B. Mille, P. Devi, S. Ravichandran, E. Lescrinier, E. Waelkens, L. D’souza, P. Herdewijn, J. Tytgat   +10 more
semanticscholar   +1 more source