Results 91 to 100 of about 916,915 (144)

Fluorescent α-Conotoxin [Q1G, ΔR14]LvIB Identifies the Distribution of α7 Nicotinic Acetylcholine Receptor in the Rat Brain

Marine Drugs
α7 nicotinic acetylcholine receptors (nAChRs) are mainly distributed in the central nervous system (CNS), including the hippocampus, striatum, and cortex of the brain. The α7 nAChR has high Ca2+ permeability and can be quickly activated and desensitized,
Hongyu Shan, Nan Wang, Xinyu Gao, Zihan Wang, Jinpeng Yu, Dongting Zhangsun, Xiaopeng Zhu, Sulan Luo   +7 more
doaj   +1 more source

Structure/activity relationship of alpha-conotoxins targeting GABAB receptor

, 2011
Conotoxins are small disulfide rich peptides derived from the venom of Cone snails. They target different receptors in the nervous system with high selectivity and potency making them valuable as drug leads or drug themselves.
Køller, Katrine Sperstad
core  

Characterization and SAR studies of Novel and Selected α- and μ- Conotoxins

, 2011
Conotoxins are small disulfide rich peptides present in cone snail venom. They target a wide array of receptors and ion-channels and exhibit extensive pharmacological diversity.
Kalyana Bharati Akondi
core  

Prediction of Specificity of α-Conotoxins to Subtypes of Human Nicotinic Acetylcholine Receptors with Semi-supervised Machine Learning. [PDF]

ACS Chem Neurosci
Do HN, Kubicek-Sutherland JZ, Gnanakaran S.   +2 more
europepmc   +1 more source

Novel ω-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes

, 2000
ω-Conotoxins selective for N-type calcium channels are useful in the management of severe pain. In an attempt to expand the therapeutic potential of this class, four new ω-conotoxins (CVIA-D) have been discovered in the venom of the piscivorous cone ...
Katherine J Nielsen (20218620), Paul F Alewood (20218596), Roger Drinkwater (2335177), Peter R R Andrews (20218647), Alun Jones (139270), Richard J Lewis (20218593), Linda Thomas (535760), Trudy Bond (20218641), Jodi-Lea Matheson (20218644), Marion L Loughnan (20218605), Iain A Sharpe (20218599), Tudor Luchian (343326), David Adams (19587271), Denise Adams (552276), David J Craik (9619016)   +14 more
core   +1 more source

Synthesis, Structure and Biological Activity of CIA and CIB, Two α-Conotoxins from the Predation-Evoked Venom of Conus catus. [PDF]

Toxins (Basel), 2018
Giribaldi J, Wilson D, Nicke A, El Hamdaoui Y, Laconde G, Faucherre A, Moha Ou Maati H, Daly NL, Enjalbal C, Dutertre S.   +9 more
europepmc   +1 more source

Editorial: From Peptide and Protein Toxins to Ion Channel Structure/Function and Drug Design

Frontiers in Pharmacology, 2020
Annette Nicke, Chris Ulens, Jean-Francois Rolland, Victor I. Tsetlin   +3 more
doaj   +1 more source

Computational Design of α-Conotoxins to Target Specific Nicotinic Acetylcholine Receptor Subtypes. [PDF]

Chemistry
Wu X, Hone AJ, Huang YH, Clark RJ, McIntosh JM, Kaas Q, Craik DJ.   +6 more
europepmc   +1 more source

Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation

, 2008
α-Conotoxins Vc1.1 and Rg1A are peptides from the venom of marine Conus snails that are currently in development as a treatment for neuropathic pain.
Géza Berecki (358061), David Adams (19587271), Richard J Clark (20218587), David J Craik (9619016), Brid P Callaghan (14880337), Alison Haythornthwaite (20218590)   +5 more
core  

From Marine Peptides to Oncology: The Therapeutic Potential of Conotoxins in Cancer Treatment. [PDF]

Chem Biodivers
Awais S, Javed MA, Ali R, Shahid M, Shahid MA, Masaud H, Ali N.   +6 more
europepmc   +1 more source