New family of conotoxins that block voltage-gated sodium channels [PDF]
, 1995 Journal ArticleConus peptides, including ω-conotoxins and α-conotoxins (targeting calcium channels and nicotinic acetylcholine receptors, respectively) have been useful ligands in neuroscience.
Hasson, Arik, Olivera, Baldomero M.
core
Biohazards of Protein Biotoxins [PDF]
, 2007 Biotoxins are toxic substances produced by a living organism that cause diseases in humanbeings, animals, or plants. The agent may be lethal or incapacitating. The new, emerging threatagents are biotoxins produced by animals, plants, fungi, and bacteria.
Daniel Jun +5 more
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Marine Drugsα-Conotoxins (α-CTxs) are structurally related peptides that antagonize nicotinic acetylcholine receptors (nAChRs), which may serve as new alternatives to opioid-based treatment for pain-related conditions.
Tianmiao Li +7 more
doaj +1 more source
Structure–Activity Studies of Cysteine‐Rich α‐Conotoxins that Inhibit High‐Voltage‐Activated Calcium Channels via GABAB Receptor Activation Reveal a Minimal Functional Motif [PDF]
, 2016 Bodil B. Carstens +13 more
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Macrocyclization Reactions: The Importance of Conformational, Configurational, and Template-Induced Preorganization [PDF]
, 2015 The success of a given macrocyclization reaction involves a very delicate balance of many different factors. First, a proper understanding of the basic thermodynamic and kinetic concepts underlying these processes is essential in defining the strategies ...
Burguete, M. Isabel +3 more
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Recombinant Expression and Characterization of α-Conotoxin LvIA in Escherichia coli [PDF]
, 2016 Xiaopeng Zhu +6 more
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An Investigation of Three-Finger Toxin—nAChR Interactions through Rosetta Protein Docking [PDF]
, 2023 Three-finger toxins (3FTX) are a group of peptides that affect multiple receptor types. One group of proteins affected by 3FTX are nicotinic acetylcholine receptors (nAChR).
Gulsevin, Alican, Meiler, Jens
core +1 more source
A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity
Frontiers in PharmacologyBackground and PurposeNicotinic acetylcholine receptors (nAChRs), which are expressed throughout the mammalian brain, mediate a variety of physiological functions. Despite their widespread presence, the functions of nAChRs are not yet fully understood. α-
Wen Wang +9 more
doaj +1 more source
Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. [PDF]
RSC Med Chem, 2021 Ho TNT +8 more
europepmc +1 more source
α-Conotoxin ImI-modified polymeric micelles as potential nanocarriers for targeted docetaxel delivery to α7-nAChR overexpressed non-small cell lung cancer [PDF]
, 2018 Dong Mei +7 more
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