Results 81 to 90 of about 916,915 (144)

Role of Cys(I)-Cys(III) Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors

, 2017
α-Conotoxins preferentially antagonize muscle and neuronal nicotinic acetylcholine receptors (nAChRs). Native α-conotoxins have two disulfide links, CI-CIII and CII-CIV, and owing to the inherent properties of disulfide bonds, α-conotoxins have been ...
Han Shen Tae (19586293), Quentin Kaas (26864), Tao Jiang (28401), David Adams (19587271), Nargis Tabassum (4372249), Xinying Jia (2157784), Rilei Yu (228408)   +6 more
core   +1 more source

Subtype-Selective Peptide and Protein Neurotoxic Inhibitors of Nicotinic Acetylcholine Receptors Enhance Proliferation of Patient-Derived Glioblastoma Cell Lines

Toxins
Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer, with a poor prognosis. GBM cells, which develop in the environment of neural tissue, often exploit neurotransmitters and their receptors to promote their own growth and invasion ...
Elena Gondarenko, Diana Mazur, Marina Masliakova, Yana Ryabukha, Igor Kasheverov, Yuri Utkin, Victor Tsetlin, Mikhail Shahparonov, Denis Kudryavtsev, Nadine Antipova   +9 more
doaj   +1 more source

A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity

Frontiers in Pharmacology
Background and PurposeNicotinic acetylcholine receptors (nAChRs), which are expressed throughout the mammalian brain, mediate a variety of physiological functions. Despite their widespread presence, the functions of nAChRs are not yet fully understood. α-
Wen Wang, Wen Wang, Meiting Wang, Huanbai Wang, Weifeng Xu, Conggang Wang, Jie Pei, Xiaodan Li, Dongting Zhangsun, Dongting Zhangsun   +9 more
doaj   +1 more source

α-Conotoxins to explore the molecular, physiological and pathophysiological functions of neuronal nicotinic acetylcholine receptors

, 2018
International audienceThe vast diversity of neuronal nicotinic acetylcholine subunits expressed in the central and peripheral nervous systems, as well as in non-neuronal tissues, constitutes a formidable challenge for researchers and clinicians to ...
Giribaldi, Julien, Dutertre, Sébastien, Sébastien Dutertre, Julien Giribaldi   +3 more
core   +1 more source

Stapling Cysteine[2,4] Disulfide Bond of α-Conotoxin LsIA and Its Potential in Target Delivery

Marine Drugs
α-Conotoxins, as selective nAChR antagonists, can be valuable tools for targeted drug delivery and fluorescent labeling, while conotoxin-drug or conotoxin-fluorescent conjugates through the disulfide bond are rarely reported.
Xin Sun, Jiangnan Hu, Maomao Ren, Hong Chang, Dongting Zhangsun, Baojian Zhang, Shuai Dong   +6 more
doaj   +1 more source

In vivo and in vitro testing of native α-conotoxins from the injected venom of Conus purpurascens

, 2017
α-Conotoxins inhibit nicotinic acetylcholine receptors (nAChRs) and are used as probes to study cholinergic pathways in vertebrates. Model organisms, such as Drosophila melanogaster, express nAChRs in their CNS that are suitable to investigate the ...
Mickelene Hoggard (20242440), Frank Marí (416776), Herminsul Cano (20242446), Han Shen Tae (19586293), Alena Rodriguez (20242443), David Adams (19587271), Tanja A Godenschwege (20242449), Evan Clark (17250655)   +7 more
core   +1 more source

Using Constellation Pharmacology to Characterize a Novel α-Conotoxin from Conus ateralbus

Marine Drugs
The venom of cone snails has been proven to be a rich source of bioactive peptides that target a variety of ion channels and receptors. α-Conotoxins (αCtx) interact with nicotinic acetylcholine receptors (nAChRs) and are powerful tools for investigating ...
Jorge L. B. Neves, Cristoval Urcino, Kevin Chase, Cheryl Dowell, Arik J. Hone, David Morgenstern, Victor M. Chua, Iris Bea L. Ramiro, Julita S. Imperial, Lee S. Leavitt, Jasmine Phan, Fernando A. Fisher, Maren Watkins, Shrinivasan Raghuraman, Jortan O. Tun, Beatrix M. Ueberheide, J. Michael McIntosh, Vitor Vasconcelos, Baldomero M. Olivera, Joanna Gajewiak   +19 more
doaj   +1 more source

Efficient binding of 4/7 α-conotoxins to nicotinic α4β2 receptors is prevented by Arg185 and Pro195 in the α4 subunit

, 2012
α-Conotoxins are subtype-selective nicotinic acetylcholine receptor (nAChR) antagonists. Although potent α3β2 nAChR-selective α-conotoxins have been identified, currently characterized α-conotoxins show no or only weak affinity for α4β2 nAChRs, which are,
Grubmüller, H., Sporning, Annett, Grubmüller, Helmut, Schemm, Rudolf, Grubmueller, Helmut, Beissner, M., Dutertre, S., Sporning, A., Danker, Timm, Nicke, Annette, Danker, T., Schemm, R., Beissner, Mirko, Dutertre, Sebastien, Nicke, A.   +14 more
core   +1 more source

Corrigendum: Crystal structure of the monomeric extracellular domain of α9 nicotinic receptor subunit in complex with α-conotoxin RgIA: Molecular dynamics insights into RgIA binding to α9α10 nicotinic receptors

Frontiers in Pharmacology, 2022
Marios Zouridakis, Athanasios Papakyriakou, Igor A. Ivanov, Igor E. Kasheverov, Igor E. Kasheverov, Victor Tsetlin, Victor Tsetlin, Socrates Tzartos, Socrates Tzartos, Petros Giastas   +9 more
doaj   +1 more source

On-resin strategy to label α-conotoxins: Cy5-RgIA, a potent α9α10 nicotinic acetylcholine receptor imaging probe. [PDF]

Aust J Chem, 2020
Muttenthaler M, Nevin ST, Inserra M, Lewis RJ, Adams DJ, Alewood P.   +5 more
europepmc   +1 more source