Results 61 to 70 of about 2,250 (207)

Marine pharmacology in 2009-2011: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action. [PDF]

, 2013
The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this review, following the format used in the 1998–2008 reviews of this series.
A. D. Rodriguez, A. M. S. Mayer, N. Fusetani, TAGLIALATELA SCAFATI, ORAZIO   +3 more
core   +2 more sources

α‐Synuclein oligomers slow down action potential firing and enhance dopamine release by increasing Cav2.2 currents in midbrain dopaminergic neurons

The Journal of Physiology, Volume 604, Issue 7, Page 3094-3113, 1 April 2026.
Abstract figure legend Left: the spontaneous quantal release of dopamine (DA) occurs at very low frequency in control conditions. Right: exogenous α‐synuclein potentiates Cav2.2 currents and DA release but drastically reduces the spontaneous firing rate of substantia nigra DA neurons.
Giulia Tomagra, Anthony Battaglia, Claudio Franchino, Sara Bonzano, Federico Picollo, Giuseppe Chiantia, Antonio de Iure, Paolo Calabresi, Barbara Picconi, Emilio Carbone, Silvia De Marchis, Andrea Marcantoni, Valentina Carabelli   +12 more
wiley   +1 more source

Loop2 Size Modification Reveals Significant Impacts on the Potency of α-Conotoxin TxID

Marine Drugs, 2023
α4/6-conotoxin TxID, which was identified from Conus textile, simultaneously blocks rat (r) α3β4 and rα6/α3β4 nicotinic acetylcholine receptors (nAChRs) with IC50 values of 3.6 nM and 33.9 nM, respectively.
Jianying Dong, Panpan Zhang, Junjie Xie, Ting Xie, Xiaopeng Zhu, Dongting Zhangsun, Jinpeng Yu, Sulan Luo   +7 more
doaj   +1 more source

The Allosteric Activation of α7 nAChR by α-Conotoxin MrIC Is Modified by Mutations at the Vestibular Site [PDF]

, 2023
α-conotoxins are 13–19 amino acid toxin peptides that bind various nicotinic acetylcholine receptor (nAChR) subtypes. α-conotoxin Mr1.7c (MrIC) is a 17 amino acid peptide that targets α7 nAChR.
Gulsevin, Alican, Jin, Aihua H., Meiler, Jens, Papke, Roger L., Stokes, Clare, Tran, Hue N. T., Vetter, Irina   +6 more
core   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, Volume 13, Issue 18, 27 March 2026.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Protein engineering strategies to optimise recombinant product synthesis and accumulation in Nicotiana benthamiana

Plant Biotechnology Journal, Volume 24, Issue 1, Page 31-43, January 2026.
Summary In plant molecular farming, recombinant products include traditional protein targets, such as antibodies, antigens, and enzymes, but also increasingly refers to high‐value peptides, and small molecules produced by heterologous enzymatic pathways.
Maxim D. Harding, Frank Sainsbury
wiley   +1 more source

Hyperpolarization Modulation of the T‐Type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects

Angewandte Chemie, Volume 137, Issue 27, July 1, 2025.
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Ryo Fukuoka, Yusuke Yano, Nozomi Hara, Chihiro Sadamoto, Andres D. Maturana, Masaki Kita   +5 more
wiley   +2 more sources

A Single Amino Acid Replacement Boosts the Analgesic Activity of α-Conotoxin AuIB through the Inhibition of the GABA_BR-Coupled N-Type Calcium Channel

Marine Drugs, 2022
α-conotoxin AuIB is the only one of the 4/6 type α-conotoxins (α-CTxs) that inhibits the γ-aminobutyric acid receptor B (GABABR)-coupled N-type calcium channel (CaV2.2).
Yuanmei Wei, Min Zhang, Shuo Yu, Qiuyuan Huang, Rongfang Chen, Shujing Xu, Yue Huang, Yunzhou Yu, Ming Liao, Qiuyun Dai   +9 more
doaj   +1 more source

The Potential Role of Calcium Channels in Pulmonary Hypertension

BioMed Research International, Volume 2026, Issue 1, 2026.
Pulmonary hypertension (PH) is a severe cardiovascular syndrome characterized by progressively elevated pulmonary arterial pressure and driven pathologically by sustained vasoconstriction and irreversible vascular remodeling. Growing evidence underscores the central role of calcium ion (Ca2+) signaling networks in PH pathogenesis, which dynamically ...
Ping Wu, Dongyang Zhong, Xuqing He, Ying Li, Hui Zhang, Venkatesh Ravula   +5 more
wiley   +1 more source

Single Amino Acid Substitution in Loop1 Switches the Selectivity of α-Conotoxin RegIIA towards the α7 Nicotinic Acetylcholine Receptor

Marine Drugs
α-Conotoxins are disulfide-rich peptides obtained from the venom of cone snails, which are considered potential molecular probes and drug leads for nAChR-related disorders.
Jinpeng Yu, Junjie Xie, Yuting Ma, Pengcheng Wei, Panpan Zhang, Zepei Tang, Xiaopeng Zhu, Dongting Zhangsun, Sulan Luo   +8 more
doaj   +1 more source