Results 51 to 60 of about 916,915 (144)

Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management

MedComm, Volume 7, Issue 5, May 2026.
The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang, Zijiao Tian, Zhaoquan Wang, Zerui Yang, Ziyao Wang, Zikang Wang, Ziqing Wang, Xingyuan He, Yu Yan, Yuanfeng Gong, Siyuan Xu, Xinyi Li, Guihua Tian   +12 more
wiley   +1 more source

A Structure‐Informed Atlas of Venom‐Derived Peptides Reveals the Organization of Chemical Space

Molecular Informatics, Volume 45, Issue 5, May 2026.
A structure‐informed atlas integrating sequence and AlphaFold‐derived features across 3,423 venom peptides reveals that chemical space is organized by disulfide‐stabilized compactness and electrostatic–hydrophobic balance, with functional classes clearly separated and convergent design principles overriding taxonomic origin.
Thaís Caroline Gonçalves, Eduardo Henrique Toral Cortez, Danilo T. Amaral   +2 more
wiley   +1 more source

A Single Amino Acid Replacement Boosts the Analgesic Activity of α-Conotoxin AuIB through the Inhibition of the GABA_BR-Coupled N-Type Calcium Channel

Marine Drugs, 2022
α-conotoxin AuIB is the only one of the 4/6 type α-conotoxins (α-CTxs) that inhibits the γ-aminobutyric acid receptor B (GABABR)-coupled N-type calcium channel (CaV2.2).
Yuanmei Wei, Min Zhang, Shuo Yu, Qiuyuan Huang, Rongfang Chen, Shujing Xu, Yue Huang, Yunzhou Yu, Ming Liao, Qiuyun Dai   +9 more
doaj   +1 more source

Single Amino Acid Substitution in Loop1 Switches the Selectivity of α-Conotoxin RegIIA towards the α7 Nicotinic Acetylcholine Receptor

Marine Drugs
α-Conotoxins are disulfide-rich peptides obtained from the venom of cone snails, which are considered potential molecular probes and drug leads for nAChR-related disorders.
Jinpeng Yu, Junjie Xie, Yuting Ma, Pengcheng Wei, Panpan Zhang, Zepei Tang, Xiaopeng Zhu, Dongting Zhangsun, Sulan Luo   +8 more
doaj   +1 more source

Conotoxin Interactions with α9α10-nAChRs: Is the α9α10-Nicotinic Acetylcholine Receptor an Important Therapeutic Target for Pain Management?

Toxins, 2015
The α9α10-nicotinic acetylcholine receptor (nAChR) has been implicated in pain and has been proposed to be a novel target for analgesics. However, the evidence to support the involvement of the α9α10-nAChR in pain is conflicted.
Sarasa A. Mohammadi, MacDonald J. Christie   +1 more
doaj   +1 more source

Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1

British Journal of Pharmacology, Volume 183, Issue 9, Page 1845-1859, May 2026.
Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim, Junhyuk Woo, Sungmin Pak, Joonho Paik, Gyu‐Sang Hong, Ji Hun Wi, Sanghee Lee, Cristina Fenollar‐Ferrer, Kyungreem Han, Young Kee Shin, Uhtaek Oh   +10 more
wiley   +1 more source

Crystal Structure of the Monomeric Extracellular Domain of α9 Nicotinic Receptor Subunit in Complex With α-Conotoxin RgIA: Molecular Dynamics Insights Into RgIA Binding to α9α10 Nicotinic Receptors

Frontiers in Pharmacology, 2019
The α9 subunit of nicotinic acetylcholine receptors (nAChRs) exists mainly in heteropentameric assemblies with α10. Accumulating data indicate the presence of three different binding sites in α9α10 nAChRs: the α9(+)/α9(−), the α9(+)/α10(−), and the α10(+)
Marios Zouridakis, Athanasios Papakyriakou, Igor A. Ivanov, Igor E. Kasheverov, Igor E. Kasheverov, Victor Tsetlin, Victor Tsetlin, Socrates Tzartos, Socrates Tzartos, Petros Giastas   +9 more
doaj   +1 more source

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, Volume 111, Issue 4, Page 2026-2043, 1 April 2026.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

α‐Synuclein oligomers slow down action potential firing and enhance dopamine release by increasing Cav2.2 currents in midbrain dopaminergic neurons

The Journal of Physiology, Volume 604, Issue 7, Page 3094-3113, 1 April 2026.
Abstract figure legend Left: the spontaneous quantal release of dopamine (DA) occurs at very low frequency in control conditions. Right: exogenous α‐synuclein potentiates Cav2.2 currents and DA release but drastically reduces the spontaneous firing rate of substantia nigra DA neurons.
Giulia Tomagra, Anthony Battaglia, Claudio Franchino, Sara Bonzano, Federico Picollo, Giuseppe Chiantia, Antonio de Iure, Paolo Calabresi, Barbara Picconi, Emilio Carbone, Silvia De Marchis, Andrea Marcantoni, Valentina Carabelli   +12 more
wiley   +1 more source

α-Conotoxin Decontamination Protocol Evaluation: What Works and What Doesn’t

Toxins, 2017
Nine publically available biosafety protocols for safely handling conotoxin peptides were tested to evaluate their decontamination efficacy. Circular dichroism (CD) spectroscopy and mass spectrometry (MS) were used to assess the effect of each chemical ...
Matthew W. Turner, John R. Cort, Owen M. McDougal   +2 more
doaj   +1 more source