Results 31 to 40 of about 916,915 (144)
Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors [PDF]
, 2013 Venoms from cone snails (Conidae) have been extensively studied during the last decades, but those from other members of the suborder Toxoglossa, such as of Terebridae and Turridae superfamilies attracted less interest so far. Here, we report the effects
Wunder, C. +26 more
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, 2023 Elevenins are peptides found in a range of organisms, including arthropods, annelids, nematodes, and molluscs. They consist of 17 to 19 amino acid residues with a single conserved disulfide bond.
Samuel D Robinson (20268759) +9 more
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Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails
Marine Drugs, 2018 Marine cone snails are a large family of gastropods that have evolved highly potent venoms for predation and defense. The cone snail venom has exceptional molecular diversity in neuropharmacologically active compounds, targeting a range of receptors, ion
Nikita Abraham, Richard J. Lewis
doaj +1 more source
Monkey adrenal chromaffin cells express α6β4* nicotinic acetylcholine receptors. [PDF]
PLoS ONE, 2014 Nicotinic acetylcholine receptors (nAChRs) that contain α6 and β4 subunits have been demonstrated functionally in human adrenal chromaffin cells, rat dorsal root ganglion neurons, and on noradrenergic terminals in the hippocampus of adolescent mice.
Alicia Hernández-Vivanco +5 more
doaj +1 more source
, 2021 The short disulfide-rich α-conotoxins derived from the venom of Conus snails comprise a conserved CICII(m)CIII(n)CIV cysteine framework (m and n, number of amino acids) and the majority antagonize nicotinic acetylcholine receptors (nAChRs).
Paul F Alewood (20218596) +4 more
core +1 more source
α-Conotoxin Peptidomimetics: Probing the Minimal Binding Motif for Effective Analgesia
Toxins, 2020 Several analgesic α-conotoxins have been isolated from marine cone snails. Structural modification of native peptides has provided potent and selective analogues for two of its known biological targets—nicotinic acetylcholine and γ-aminobutyric acid ...
Adam C. Kennedy +5 more
doaj +1 more source
Conotoxins: structure, therapeutic potential and pharmacological applications. [PDF]
, 2016 Cone snails, also known as marine gastropods, from Conus genus produce in their venom a diverse range of small pharmacologically active structured peptides called conotoxins.
Mir, R. +4 more
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Toxinology of Marine Venomous Snails
Iranian South Medical Journal, 2021 A surprisingly large number of sea snail species are venomous. Cone snail venoms are produced in a lengthy tubular duct from a complex venom gland and form a cocktail of many toxins, particularly conotoxins which have high potency and specificity for ...
Gholam Hossein Mohebbi, Iraj Nabipour
doaj
Biomedicines, 2020 Voltage-gated sodium (NaV) channel subtypes, including NaV1.7, are promising targets for the treatment of neurological diseases, such as chronic pain. Cone snail-derived µ-conotoxins are small, potent NaV channel inhibitors which represent potential drug
Kirsten L. McMahon +5 more
doaj +1 more source
Marine Drugs, 2022 α6β4 nAChR is expressed in the peripheral and central nervous systems and is associated with pain, addiction, and movement disorders. Natural α-conotoxins (α-CTxs) can effectively block different nAChR subtypes with higher efficacy and selectivity ...
Liujun Wang +5 more
doaj +1 more source