Results 21 to 30 of about 916,915 (144)

Characterisation of a Novel A-Superfamily Conotoxin

Biomedicines, 2020
Conopeptides belonging to the A-superfamily from the venomous molluscs, Conus, are typically α-conotoxins. The α-conotoxins are of interest as therapeutic leads and pharmacological tools due to their selectivity and potency at nicotinic acetylcholine ...
David T. Wilson, Paramjit S. Bansal, David A. Carter, Irina Vetter, Annette Nicke, Sébastien Dutertre, Norelle L. Daly   +6 more
doaj   +1 more source

Dimerization of α‑Conotoxins as a Strategy to Enhance the Inhibition of the Human α7 and α9α10 Nicotinic Acetylcholine Receptors

, 2020
The affinity of α-conotoxins, a class of nicotinic acetylcholine receptor (nAChR) peptide inhibitors, can be enhanced by dendrimerization. It has been hypothesized that this improvement arose from simultaneous binding of the α-conotoxins to several ...
David J. Adams (119198), Han-Shen Tae (1639798), Xiaoxiao Xu (1777678), Tao Jiang (28401), Jiazhen Liang (8448420), Rilei Yu (228408)   +5 more
core   +5 more sources

A 4/8 Subtype α-Conotoxin Vt1.27 Inhibits N-Type Calcium Channels With Potent Anti-Allodynic Effect

Frontiers in Pharmacology, 2022
A novel 4/8 subtype α-conotoxin, Vt1.27 (NCCMFHTCPIDYSRFNC-NH2), was identified from Conus vitulinus in the South China Sea by RACE methods. The peptide was synthesized and structurally characterized.
Shuo Wang, Shuo Wang, Peter Bartels, Cong Zhao, Arsalan Yousuf, Zhuguo Liu, Shuo Yu, Anuja R. Bony, Xiaoli Ma, Qin Dai, Ting Sun, Na Liu, Mengke Yang, Rilei Yu, Weihong Du, David J. Adams, Qiuyun Dai   +16 more
doaj   +1 more source

Venom duct origins of prey capture and defensive conotoxins in piscivorous Conus striatus

Scientific Reports, 2021
The venom duct origins of predatory and defensive venoms has not been studied for hook-and-line fish hunting cone snails despite the pharmacological importance of their venoms. To better understand the biochemistry and evolution of injected predatory and
S. W. A. Himaya, Ai-Hua Jin, Brett Hamilton, Subash K. Rai, Paul Alewood, Richard J. Lewis   +5 more
doaj   +1 more source

Structural similarities reveal an expansive conotoxin family with a two-finger toxin fold. [PDF]

Protein Sci
Abstract Venomous animals have evolved a diverse repertoire of toxins with considerable pharmaceutical potential. The rapid evolution of peptide toxins, such as the conotoxins produced by venomous marine cone snails, often complicates efforts to infer their evolutionary relationships based solely on sequence information.
Khilji MS, Hackney CM, Koch TL, Hone AJ, Rogalski A, Watkins M, Tun J, McIntosh JM, Olivera B, Safavi-Hemami H, Teilum K, Ellgaard L.   +11 more
europepmc   +2 more sources

Rigidity of loop 1 contributes to equipotency of globular and ribbon isomers of α-conotoxin AusIA

Scientific Reports, 2021
α-Conotoxins are small disulfide-rich peptides targeting nicotinic acetylcholine receptors (nAChRs) characterised by a CICII-Xm-CIII-Xn-CIV framework that invariably adopt the native globular conformations which is typically most potent. α-Conotoxins are
Thao N. T. Ho, Nikita Abraham, Richard J. Lewis   +2 more
doaj   +1 more source

Venom-Derived Neurotoxins Targeting Nicotinic Acetylcholine Receptors

Molecules, 2021
Acetylcholine was the first neurotransmitter described. The receptors targeted by acetylcholine are found within organisms spanning different phyla and position themselves as very attractive targets for predation, as well as for defense. Venoms of snakes
Ayaulym Bekbossynova, Albina Zharylgap, Olena Filchakova   +2 more
doaj   +1 more source

An N-Terminally Elongated Peptide From Conus rolani Defines a New Class of Ribbon α-Conotoxins Targeting Muscle nAChRs. [PDF]

FASEB J
Conotoxins, peptides found in cone snail venoms, selectively target ion channels and receptors to incapacitate prey. α-Conotoxins are extensively investigated for their potent modulation of nicotinic acetylcholine receptors (nAChRs). This study describes
Giglio ML, Flórez-Salcedo P, Azam L, Watkins M, Koch TL, Basgall-De la Rosa E, Douglass AD, McIntosh JM, Olivera BM, Gajewiak J.   +9 more
europepmc   +2 more sources

Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. [PDF]

PLoS Computational Biology, 2011
α-Conotoxins potently inhibit isoforms of nicotinic acetylcholine receptors (nAChRs), which are essential for neuronal and neuromuscular transmission.
Rilei Yu, David J Craik, Quentin Kaas
doaj   +1 more source

Synthetic α-Conotoxin Mutants as Probes for Studying Nicotinic Acetylcholine Receptors and in the Development of Novel Drug Leads

Toxins, 2010
α-Conotoxins are peptide neurotoxins isolated from venomous marine cone snails that are potent and selective antagonists for different subtypes of nicotinic acetylcholine receptors (nAChRs).
Christopher J. Armishaw
doaj   +1 more source