Results 41 to 50 of about 2,250 (207)

Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases [PDF]

, 2014
Marine invertebrates produce a plethora of bioactive compounds, which serve as inspiration for marine biotechnology, particularly in drug discovery programs and biomaterials development.
Andrade, Paula B., Ferreres, Federico, Grosso, Clara, Valentão, Patricia   +3 more
core   +2 more sources

Toxinology of Marine Venomous Snails

Iranian South Medical Journal, 2021
A surprisingly large number of sea snail species are venomous. Cone snail venoms are produced in a lengthy tubular duct from a complex venom gland and form a cocktail of many toxins, particularly conotoxins which have high potency and specificity for ...
Gholam Hossein Mohebbi, Iraj Nabipour
doaj  

A Novel α4/7-Conotoxin QuIA Selectively Inhibits α3β2 and α6/α3β4 Nicotinic Acetylcholine Receptor Subtypes with High Efficacy

Marine Drugs, 2022
α6β4 nAChR is expressed in the peripheral and central nervous systems and is associated with pain, addiction, and movement disorders. Natural α-conotoxins (α-CTxs) can effectively block different nAChR subtypes with higher efficacy and selectivity ...
Liujun Wang, Xixi Wu, Xiaopeng Zhu, Dongting Zhangsun, Yong Wu, Sulan Luo   +5 more
doaj   +1 more source

Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible Na_V Channel Inhibitor

Biomedicines, 2020
Voltage-gated sodium (NaV) channel subtypes, including NaV1.7, are promising targets for the treatment of neurological diseases, such as chronic pain. Cone snail-derived µ-conotoxins are small, potent NaV channel inhibitors which represent potential drug
Kirsten L. McMahon, Hue N.T. Tran, Jennifer R. Deuis, Richard J. Lewis, Irina Vetter, Christina I. Schroeder   +5 more
doaj   +1 more source

Microwave-assisted RCM for the synthesis of carbocyclic peptides [PDF]

, 2015
Microwave irradiation dramatically improves the efficiency of ring closing metathesis (RCM) reactions of resin-attached peptides and the technology is illustrated by the highly selective synthesis of dicarba analogues of α-conotoxin IMI.
Elaridi, Jomana, Jackson, W. Roy, Mujcinovic, Selma, Robinson, Andrea J., Van Lierop, Bianca J.   +4 more
core   +1 more source

Review

, 2020
The chalcogen elements oxygen, sulfur, and selenium are essential constituents of side chain functions of natural amino acids. Conversely, no structural and biological function has been discovered so far for the heavier and more metallic tellurium ...
Agh R, Arai K, Baskakov IV, Creighton TE, Dittmer K, Du Vigneaud V, Janeček J, Metanis N, Musiol HJ, Muttenthaler M, Nygard B, O'Donnell ME, Welch M, Yang F   +13 more
core   +1 more source

Heterologous expression and nonsense suppression provide insights into agonist behavior at α6β2 nicotinic acetylcholine receptors [PDF]

, 2015
The α6-containing subtypes of the nicotinic acetylcholine receptor (nAChR) are localized to presynaptic terminals of the dopaminergic pathways of the central nervous system.
Dougherty, Dennis A., Lester, Henry A., Limapichat, Walrati, Post, Michael R.   +3 more
core   +1 more source

Interactions of the α3β2 Nicotinic Acetylcholine Receptor Interfaces with α-Conotoxin LsIA and its Carboxylated C-terminus Analogue: Molecular Dynamics Simulations

Marine Drugs, 2020
Notably, α-conotoxins with carboxy-terminal (C-terminal) amidation are inhibitors of the pentameric nicotinic acetylcholine receptors (nAChRs), which are therapeutic targets for neurological diseases and disorders.
Jierong Wen, David J. Adams, Andrew Hung
doaj   +1 more source

Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain [PDF]

, 2017
Opioids are first-line drugs for moderate to severe acute pain and cancer pain. However, these medications are associated with severe side effects, and whether they are efficacious in treatment of chronic nonmalignant pain remains controversial ...
Christensen, Sb, Di Cesare Mannelli, L, Elmslie, Ks, Gajewiak, J, Ghelardini, C, Iadonato, Sp, McIntosh, Jm, Mercado, Jl, Olivera, Bm, Ramachandra, R, Romero, Hk, Vetter, De   +11 more
core   +2 more sources

Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation – Suggestion of a Binding Mode at the α7 nAChR [PDF]

, 2019
Peptides derived from animal venoms provide important research tools for biochemical and pharmacological characterization of receptors, ion channels, and transporters.
Anangi, Raveendra, Clark, Richard J., Craik, David J., Dutertre, Sebastien, El Hamdaoui, Yamina, Giribaldi, Julien, Herzig, Volker, Kaas, Quentin, King, Glenn F., Nicke, Annette, Wu, Xiaosa   +10 more
core   +5 more sources