Pharmacological Research, 2023 The pentameric nicotinic acetylcholine receptors (nAChRs) are typically classed as muscle- or neuronal-type, however, the latter has also been reported in non-neuronal cells.
Han-Shen Tae, David J. Adams
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Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview
Marine Drugs, 2014 Marine snails of the genus Conus are a large family of predatory gastropods with an unparalleled molecular diversity of pharmacologically active compounds in their venom.
Eline K M Lebbe +2 more
exaly +3 more sources
α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition. [PDF]
Br J Pharmacol, 2018 Neuronal α3-containing nicotinic acetylcholine receptors (nAChRs) in the peripheral nervous system (PNS) and non-neuronal tissues are implicated in a number of severe disease conditions ranging from cancer to cardiovascular diseases and chronic pain ...
Cuny H +4 more
europepmc +4 more sources
Marine-Derived Ligands of Nicotinic Acetylcholine Receptors in Cancer Research [PDF]
Marine DrugsMarine sources contain compounds that act on a wide variety of systems, including ligand-gated ion channels. This review will focus on the effectors of nicotinic acetylcholine receptors (nAChRs), for which the diversity of ligands and modulators from ...
Igor E. Kasheverov +3 more
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Role of CysI-CysIII Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors. [PDF]
ACS Omega, 2017 α-Conotoxins preferentially antagonize muscle and neuronal nicotinic acetylcholine receptors (nAChRs). Native α-conotoxins have two disulfide links, C-C and C-C, and owing to the inherent properties of disulfide bonds, α-conotoxins have been ...
Tabassum N +6 more
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Key Structural Determinants in the Agonist Binding Loops of Human β2 and β4 Nicotinic Acetylcholine Receptor Subunits Contribute to α3β4 Subtype Selectivity of α-Conotoxins. [PDF]
J Biol Chem, 2016 α-Conotoxins represent a large group of pharmacologically active peptides that antagonize nicotinic acetylcholine receptors (nAChRs). The α3β4 nAChR, a predominant subtype in the peripheral nervous system, has been implicated in various ...
Cuny H +4 more
europepmc +2 more sources
Interaction of α9α10 Nicotinic Receptors With Peptides and Proteins From Animal Venoms
Frontiers in Cellular Neuroscience, 2021 Unlike most neuronal nicotinic acetylcholine receptor (nAChR) subunits, α7, α9, and α10 subunits are able to form functional homo- or heteromeric receptors without any β subunits.
Victor Tsetlin +11 more
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Conkazal-M1 from the MKAVA family of conotoxins: A dual-function protease inhibitor and neuroactive peptide. [PDF]
Protein SciAbstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Hackney CM +12 more
europepmc +2 more sources
Inhibition of cholinergic pathways in Drosophila melanogaster by α-conotoxins.
FASEB J, 2015 Nicotinic acetylcholine receptors (nAChRs) play a pivotal role in synaptic transmission of neuronal signaling pathways and are fundamentally involved in neuronal disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia.
Heghinian MD +4 more
europepmc +2 more sources
Marine Drugs, 2021 Cone snails are venomous marine predators that rely on fast-acting venom to subdue their prey and defend against aggressors. The conotoxins produced in the venom gland are small disulfide-rich peptides with high affinity and selectivity for their ...
Julien Giribaldi +7 more
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