Interaction of α9α10 Nicotinic Receptors With Peptides and Proteins From Animal Venoms [PDF]
Frontiers in Cellular Neuroscience, 2021 Unlike most neuronal nicotinic acetylcholine receptor (nAChR) subunits, α7, α9, and α10 subunits are able to form functional homo- or heteromeric receptors without any β subunits.
Victor Tsetlin +11 more
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Orthosteric and/or Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models [PDF]
Marine Drugs, 2018 α-Conotoxins from Conus snails are capable of distinguishing muscle and neuronal nicotinic acetylcholine receptors (nAChRs). α-Conotoxin RgIA and αO-conotoxin GeXIVA, blocking neuronal α9α10 nAChR, are potential analgesics ...
Elena V. Kryukova +8 more
doaj +2 more sources
Computational Design of α-Conotoxins to Target Specific Nicotinic Acetylcholine Receptor Subtypes. [PDF]
Chemistry, 2023 Wu X +6 more
europepmc +3 more sources
Rationally Designed α-Conotoxin Analogues Maintained Analgesia Activity and Weakened Side Effects [PDF]
, 2019 A lack of specificity is restricting the further application of conotoxin from Conus bullatus (BuIA). In this study, an analogue library of BuIA was established and virtual screening was used, which identified high α7 nicotinic acetylcholine receptor ...
Chen Liu +9 more
openalex +4 more sources
Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview
Marine Drugs, 2014 Marine snails of the genus Conus are a large family of predatory gastropods with an unparalleled molecular diversity of pharmacologically active compounds in their venom.
Eline K M Lebbe +2 more
exaly +3 more sources
Marine-Derived Ligands of Nicotinic Acetylcholine Receptors in Cancer Research [PDF]
Marine DrugsMarine sources contain compounds that act on a wide variety of systems, including ligand-gated ion channels. This review will focus on the effectors of nicotinic acetylcholine receptors (nAChRs), for which the diversity of ligands and modulators from ...
Igor E. Kasheverov +3 more
doaj +2 more sources
Influence of Disulfide Connectivity on Structure and Bioactivity of α-Conotoxin TxIA [PDF]
Molecules, 2014 Cone snails express a sophisticated arsenal of small bioactive peptides known as conopeptides or conotoxins (CTxs). Through evolutionary selection, these peptides have gained the ability to interact with a range of ion channels and receptors, such as ...
Yong Wu +5 more
doaj +2 more sources
Conopeptides [V11L;V16D]ArIB and RgIA4: Powerful Tools for the Identification of Novel Nicotinic Acetylcholine Receptors in Monocytes [PDF]
Frontiers in Pharmacology, 2019 Venomous marine snails of the genus Conus employ small peptides to capture prey, mainly osteichthyes, mollusks, and worms. A subset of these peptides known as α-conotoxins, are antagonists of nicotinic acetylcholine receptors (nAChRs).
Veronika Grau +5 more
doaj +3 more sources
Fluorescent α-Conotoxin [Q1G, ΔR14]LvIB Identifies the Distribution of α7 Nicotinic Acetylcholine Receptor in the Rat Brain [PDF]
Marine Drugsα7 nicotinic acetylcholine receptors (nAChRs) are mainly distributed in the central nervous system (CNS), including the hippocampus, striatum, and cortex of the brain. The α7 nAChR has high Ca2+ permeability and can be quickly activated and desensitized,
Hongyu Shan +7 more
doaj +2 more sources
Conkazal-M1 from the MKAVA family of conotoxins: A dual-function protease inhibitor and neuroactive peptide. [PDF]
Protein SciAbstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Hackney CM +12 more
europepmc +2 more sources