Results 71 to 80 of about 916,915 (144)

Nicotinic Acetylcholine Receptor Pathways in Cancer: From Psychiatric Clues to Therapeutic Opportunities

Cancer Reports, Volume 8, Issue 11, November 2025.
ABSTRACT Background The prevalence of cancer poses significant challenges to treatment, largely because of drug resistance along with other side effects. Current studies have been investigating the growth factors more than other biologic tumor features, such as neurobiologic features.
Mohammad Hossein Azadi, Pouya Pazooki, Soheila Ajdary, Hamed Shafaroodi   +3 more
wiley   +1 more source

Protein Folding Determinants:  Structural Features Determining Alternative Disulfide Pairing in α- and χ/λ-Conotoxins^†,‡

, 2016
α-Conotoxins isolated from Conus venoms contain 11−19 residues and preferentially fold into the globular conformation that possesses a specific disulfide pairing pattern (C1-3, C2-4).
Palmer Taylor (40801), Tse Siang Kang (2500009), Zoran Radić (2491114), Seetharama D. S. Jois (2444287), Todd T. Talley (356833), R. Manjunatha Kini (124799)   +5 more
core   +2 more sources

New family of conotoxins that block voltage-gated sodium channels [PDF]

, 1995
journal articleConus peptides, including ω-conotoxins and α-conotoxins (targeting calcium channels and nicotinic acetylcholine receptors, respectively) have been useful ligands in neuroscience.
Hasson, Arik; Spira, Micha E.; Li, Wenqin; Marsh, Maren, Olivera, Baldomero M.; McIntosh, J. Michael; Gray, William Robert; Hillyard, David R.   +1 more
core  

Medicinal chemistry, pharmacology, and therapeutic potential of α-conotoxins antagonizing the α9α10 nicotinic acetylcholine receptor

, 2021
α-Conotoxins are disulfide-rich and well-structured peptides, most of which can block nicotinic acetylcholine receptors (nAChRs) with exquisite selectivity and potency. There are various nAChR subtypes, of which the α9α10 nAChR functions as a heteromeric
David J Adams (8273148), Tao Jiang (28401), Yanyan Chu (11654272), Han Shen Tae (20023188), Rilei Yu (228408), Xiao Li (107004)   +5 more
core   +1 more source

Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors

Marine Drugs
α-Conotoxins (α-CTxs) are structurally related peptides that antagonize nicotinic acetylcholine receptors (nAChRs), which may serve as new alternatives to opioid-based treatment for pain-related conditions.
Tianmiao Li, Han-Shen Tae, Jiazhen Liang, Zixuan Zhang, Xiao Li, Tao Jiang, David J. Adams, Rilei Yu   +7 more
doaj   +1 more source

Structure-activity studies of cysteine-rich α-Conotoxins that inhibit high voltage-activated calcium channels via GABA_B receptor activation reveal a minimal functional motif

, 2016
α-Conotoxins are disulfide-rich peptides that target nicotinic acetylcholine receptors. Recently we identified several α-conotoxins that also modulate voltage-gated calcium channels by acting as G protein-coupled GABAB receptor (GABABR) agonists. These α-
Stuart Brierley (13624672), Han Siean Lee (8459298), Joel Castro (2143660), James T Daniel (20242800), Mahsa Sadeghi (20119410), Annemie Deiteren (725885), Bodil B Carstens (20242797), Han Shen Tae (19586293), Géza Berecki (358061), David Adams (19587271), Richard J Clark (20218587), David J Craik (9619016), Kathryn A V Jackson (20245245), Tracy O'Donnell (20047074)   +13 more
core   +1 more source

Influence of Disulfide Connectivity on Structure and Bioactivity of α-Conotoxin TxIA

Molecules, 2014
Cone snails express a sophisticated arsenal of small bioactive peptides known as conopeptides or conotoxins (CTxs). Through evolutionary selection, these peptides have gained the ability to interact with a range of ion channels and receptors, such as ...
Yong Wu, Xiaosa Wu, Jinpeng Yu, Xiaopeng Zhu, Dongting Zhangsun, Sulan Luo   +5 more
doaj   +1 more source

Analgesic α-conotoxins modulate native and recombinant GIRK1/2 channels via activation of GABAB receptors and reduce neuroexcitability

, 2022
Background and Purpose: Activation of GIRK channels via G protein-coupled GABAB receptors has been shown to attenuate nociceptive transmission. The analgesic α-conotoxin Vc1.1 activates GABAB receptors resulting in inhibition of Cav2.2 and Cav2.3 ...
Anuja R Bony (20254560), David J Adams (8273148), Jeffrey R McArthur (20251176), Rocio K Finol-Urdaneta (20251173)   +3 more
core   +1 more source

Cervical Cancer Correlates with the Differential Expression of Nicotinic Acetylcholine Receptors and Reveals Therapeutic Targets

Marine Drugs, 2019
Nicotinic acetylcholine receptors (nAChRs) are associated with various cancers, but the relation between nAChRs and cervical cancer remains unclear. Therefore, this study investigated the differential expression of nAChR subunits in human cervical cancer
Yiqiao Liu, Jiang Qian, Zhihua Sun, Dongting Zhangsun, Sulan Luo   +4 more
doaj   +1 more source

Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. [PDF]

RSC Med Chem, 2021
Ho TNT, Lee HS, Swaminathan S, Goodwin L, Rai N, Ushay B, Lewis RJ, Rosengren KJ, Conibear AC.   +8 more
europepmc   +1 more source