Results 111 to 120 of about 999,551 (181)

Neutrophil-derived defensins as modulators of innate immune function

, 2008
Cationic host defence peptides are an evolutionarily conserved component of the immune system and have been found across a wide variety of species. In lower organisms they comprise a major component of the defensive repertoire, whereas in higher species ...
Rehaume, Linda M., Hancock, Robert E. W.
core   +1 more source

Pantethine Restores Epidermal Homeostasis and Modulates Vesicle‐Associated Proteins in Psoriasis

Experimental Dermatology, Volume 35, Issue 11, November 2026.
Pantethine attenuates psoriasis‐like epidermal pathology in a full‐thickness 3D human skin model by modulating inflammatory, oxidative‐stress, differentiation and tissue‐remodelling responses, alongside changes in vesicle‐associated proteins. These findings support restoration of epidermal homeostasis, although direct effects on extracellular vesicles ...
Passanesh Sukphopetch, Kamonpan Fongsodsri, Pornanong Aramwit, Onrapak Reamtong, Tipparat Thiangtrongjit, Tapanee Kanjanapruthipong, Watcharamat Muangkaew, Sumate Ampawong   +7 more
wiley   +1 more source

c‐Jun N‐Terminal Kinase‐2 Mediates Alcohol and Corticosterone‐Induced Tissue Injury at the Gut‐Liver Axis

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Alcohol activates JNK2, leading to epithelial TJ disruption. Corticosterone activates JNK2 and causes Paneth cell dysfunction. Depletion of α‐defensins due to Paneth cell dysfunction causes gut microbiota dysbiosis. Microbiota dysbiosis and TJ disruption lead to endotoxemia, systemic inflammation, and liver damage.
Lohitha Basa, Nitesh Shashikanth, Pradeep K. Shukla, Chandra Shekhar, Avtar S. Meena, Nathan Jones, Preeti Raju, Christopher Nguyen, Samhitha Swarna, Nathaniel B. Willis, Siddabasave Gowda B Gowda, Sue‐Chin Lee, Joseph F. Pierre, RadhaKrishna Rao   +13 more
wiley   +1 more source

Alpha-defensins in the prevention of HIV transmission among breastfed infants

, 2005
α-Defensins have been observed to have anti-HIV activity but have not been investigated in relation to mother-to-child HIV transmission. We measured the concentration of α-defensins in breast milk of HIV-positive mothers and tested whether the ...
L. Kuhn, F. Lissoni, C. Vwalika, C. Kankasa, G. M. Aldrovandi, D. M. Thea, K. Semrau, M. Ghosh, P. Kasonde, D.L. Trabattoni, M.S. Clerici, M. Sinkala   +11 more
core   +1 more source

From Dysbiosis to Disease: How Vaginal Microbiota Shape Group B Streptococcus Pathogenesis

ChemBioChem, Volume 27, Issue 20, 28 October 2026.
Lactobacillus crispatus plays a critical role in the vaginal microbiome. Limiting glucose shifts metabolism toward HMO consumption and amino acid metabolism. These actions enable alkali production and competition. Homeostasis, characterized by dense Lactobacilli colonization and suppression of pathogens, provides resistance to dysbiosis.
Julie A. Talbert, Steven D. Townsend
wiley   +1 more source

Innate Immune Environment in Ileal Pouch Mucosa: α-5 Defensin Up-Regulation as Predictor of Chronic/Relapsing Pouchitis

, 2011
Background Defensins are small cationic peptides with antibacterial activity expressed only in Paneth cells (α-defensins) or generally in intestinal epithelial cells (β-defensins) that have a profound effect on gut microbiota. We have recently shown that
Ignazio Castagliuolo, Anna Pozza, Melania Scarpa, Marco Scarpa, Imerio Angriman, CASTAGLIUOLO, IGNAZIO, Romeo Bardini, SCARPA, MARCO, Renata D'Incà, Cesare Ruffolo, FAGGIAN, DIEGO, ANGRIMAN, IMERIO, POZZA, ANNA, BRUN, PAOLA, RUFFOLO, CESARE, Alessia R. Grillo, CASTORO, CARLO, Carlo Castoro, GRILLO, ALESSIA ROSARIA, Diego Faggian, Paola Brun, BARDINI, ROMEO, SCARPA, MELANIA   +22 more
core   +1 more source

Production of α-defensins 1-3 by immature (im) and mature (m) MDDCs.

, 2013
(A) Immature and mature MDDC immunophenotype from one representative healthy control individual and one HIV-infected subject. X-axis represents HLA-DR expression and Y-axis represents the surface markers indicated.
Marta Rodríguez-García (111850), Víctor Casanova (111845), Rafael Franco (111866), Núria Climent (111868), Agathe Leon (5651488), José M. Gatell (111852), Felipe García (111854), Harold Oliva (366819), Teresa Gallart (111857)   +8 more
core   +1 more source

Role of defensins in the pathogenesis of chronic lung allograft rejection [PDF]

, 2013
Chronic rejection predominantly manifested as bronchiolitis obliterans syndrome (BOS), still remains a major problem affecting long-term outcomes in human lung transplantation (LTx).
Banan, Babak, Hachem, Ramsey, Mohanakumar, Thalachallour, Nataraju, Angaswamy, Trulock, Elbert, Deepti, Saini, Tiriveedhi, Venkataswarup, Alexander, Patterson G.   +7 more
core   +1 more source

Disrupting SARS-CoV-2: molecular dynamics insights into the role of human β-defensin 2 and α-defensin 5 peptides in membrane structure alteration

Chemical Physics Impact
As a part of the host-defense system of many organisms, defensins are considered a suitable option for treating infection agents. Using the molecular dynamics simulation, this work studied the effects of two important human antimicrobial peptides, human ...
M.A. Dashti, D. Mohammad-Aghaie, O. Bavi
doaj   +1 more source

Anti-inflammatory mechanisms of the neutrophilreleased antimicrobial peptide α-defensins [PDF]

, 2014
Tissue homeostasis is necessary for optimal organ functioning. The onset of tissue trauma compromises the homeostatic environment resulting in widespread cell death with the likelihood of exposure to invading micro-organisms.
Tomlinson, Gareth Hugh
core