Results 91 to 100 of about 999,551 (181)

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

Cyclic and Acyclic Defensins Inhibit Human Immunodeficiency Virus Type-1 Replication by Different Mechanisms [PDF]

, 2010
Defensins are antimicrobial peptides expressed by plants and animals. In mammals there are three subfamilies of defensins, distinguished by structural features: α, β and θ. Alpha and β-defensins are linear peptides with broad anti-microbial activity that
Camerini, David, Selsted, Michael E., Soto, Maira, Seidel, Aprille, de Armas, Lesley R., Ye, Ying, Marcsisin, Renee A., Yarosh, William, Tran, Dat   +8 more
core  

Mouse estrous cycle regulation of vaginal versus uterine cytokines, chemokines, α-/β-defensins and TLRs [PDF]

, 2012
This study investigates the cyclic changes in innate immunity in the female reproductive tract (FRT) of mice during the estrous cycle. By examining uterine and vaginal tissues and secretions we show that innate immunity varies with the stage of the ...
Hickey, Danica K., Fahey, John V., Wira, Charles R.   +2 more
core   +1 more source

Human Neutrophil α-Defensins 1-3 Are Upregulated in the Microenvironment of Fibrotic Liver. [PDF]

Medicina (Kaunas), 2023
Abu Fanne R, Maraga E, Kassem E, Groisman G, Amsalem N, Zeina AR, Abu Mouch M, Taher R, Abu-Mouch S.   +8 more
europepmc   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Ixodes ricinus defensins attack distantly-related pathogens

, 2015
Contribution: Study design and data analysisInternational audienceAntimicrobial peptides are ubiquitous components of eukaryotic innate immunity. Defensins are a well-known family of antimicrobial peptides, widely distributed in ticks, insects, plants ...
Rahnamaeian, Mohammad, Tonk, Miray, Estrada-Peña, Agustin, Vilcinskas, Andreas, Kotsyfakis, Michalis, Rego, Ryan O.M., Cabezas Cruz, Alejandro, Grubhoffer, Libor, Valdes, James J., Grubhoffer, L., Vilcinskas, A., Rego, R.O.M., Estrada-Pena, A., Valdés, J.J., Tonk, M., Rahnamaeian, M., Cabezas-Cruz, A., Kotsyfakis, M.   +17 more
core   +1 more source

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

Journal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis, James A. Garnett, Richard P. Darveau   +2 more
wiley   +1 more source

Mouse α-Defensins: Structural and Functional Analysis of the 17 Cryptdin Isoforms Identified from a Single Jejunal Crypt. [PDF]

Infect Immun, 2023
Wang Q, Yang Y, Luo G, Zhou Y, Tolbert WD, Pazgier M, Liao C, Lu W.   +7 more
europepmc   +1 more source

Efficient production of a correctly folded mouse α-defensin, cryptdin-4, by refolding during inclusion body solubilization [PDF]

, 2015
Mammalian α-defensins contribute to innate immunity by exerting antimicrobial activity against various pathogens. To perform structural and functional analysis of α-defensins, large amounts of α-defensins are essential.
Kawano, Keiichi, Keiichi Kawano, Kamiya, Masakatsu, Kiminori Nakamura, Sato, Yuji, Aizawa, Tomoyasu, Nakamura, Kiminori, Takashi Kikukawa, Kumaki, Yasuhiro, Demura, Makoto, Satoshi Tomisawa, Tomisawa, Satoshi, Yuji Sato, Masakatsu Kamiya, Tomoyasu Aizawa, Kikukawa, Takashi, Tokiyoshi Ayabe, Ayabe, Tokiyoshi, Makoto Demura, Yasuhiro Kumaki   +19 more
core   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source