Results 81 to 90 of about 999,551 (181)
British Journal of Haematology, EarlyView.The graphical abstract provides a view on selected aspects of the pathogenesis, risk stratification and treatment of acute GVHD. Summary Acute graft‐versus‐host disease (aGVHD) remains a major complication following allogeneic haematopoietic stem cell transplantation (allo‐HSCT), representing a leading cause of non‐relapse mortality (NRM) and ...
Hazim Khatib, Robert Zeiser
wiley +1 more source
Analysis of plasma levels of α-defensins 1-3.
, 2013 (A) Plasma levels of α-defensins 1-3 detected in the different groups of HIV-infected patients, elite controllers (ELITE; n = 3), viremic controllers (VC; n = 10), viremic non-controllers (VNC; n = 5) and patients receiving HAART (HAART; n = 9).
Marta Rodríguez-García (111850) +8 more
core +1 more source
The fight of innate immunity and abnormal cannabinoids against Candida infection
British Journal of Pharmacology, EarlyView.Candida species represent the most clinically significant fungal pathogens in humans, with invasive candidiasis carrying a mortality of 30%–40% in critically ill patients despite modern antifungal therapy. The innate immune system – through the coordinated and specific activities of neutrophils, macrophages, NK cells, mast cells and eosinophils ...
Prince Ofori +2 more
wiley +1 more source
Regional variations in Paneth cell antimicrobial peptide expression along the mouse intestinal tract
BMC Immunology, 2008 Background Enteric antimicrobial peptides secreted from Paneth cells, including α-defensins (in mice named cryptdins), are key effector molecules of innate immunity in the small intestine.
Bevins Charles L +5 more
doaj +1 more source
A molecular dynamics study of human defensins HBD-1 and HNP-3 in water
, 2010 Mammalian defensins are crucial components of the innate immune system. They are characterized by three disulfide bridges and exhibit broad spectrum antibacterial activity. The spacing between the cysteines and disulfide connectivities in the two classes
Ambure, Sharadadevi +1 more
core
RNA activation in insects: From emerging evidence to molecular applications
Insect Molecular Biology, EarlyView.Canonical RNA activation involves small RNAs interacting with promoter sequences, but there is also evidence of non‐canonical RNAa in eukaryotes. Emerging evidence suggests the presence of RNAa in insects. RNAa can be utilised as a tool for functional genomic studies in insects.
Sassan Asgari
wiley +1 more source
Increased α-defensins as a blood marker for schizophrenia susceptibility
, 2008 Schizophrenia is a severe psychotic illness affecting 1% of the general population. There are no consistent pathological features, and the disorder is defined by a complex symptomatology, which overlaps with other psychiatric illnesses.
Craddock, Rachel M. +13 more
core +1 more source
Use of α-Defensins to Help Diagnose Nosocomial Ventriculitis. [PDF]
Neurocrit Care, 2023 Doub JB.
europepmc +1 more source
Hidradenitis suppurativa skin microbiome: In‐depth analysis and modulation by systemic therapies
Journal of the European Academy of Dermatology and Venereology, EarlyView.Hidradenitis suppurativa skin exhibits profound dysbiosis, characterized by the depletion of homeostatic commensals and expansion of anaerobic pathogens. Longitudinal evaluation reveals that while systemic antibiotics successfully reverse HS dysbiosis, biologics (adalimumab and secukinumab) fail to clear pathogens despite clinical healing.
Yacine Amar +8 more
wiley +1 more source
Inhibition of Pertussis Toxin by Human α-Defensins-1 and -5: Differential Mechanisms of Action. [PDF]
Int J Mol Sci, 2023 Kling C +12 more
europepmc +1 more source