Results 71 to 80 of about 999,551 (181)
VIEW, EarlyView.Periodontal homeostasis is maintained by coordinated interactions between the oral microbiome and host. Dysbiosis disrupts this ecological balance and contributes to periodontal disease, whereas multi‐omics, artificial intelligence, and microbiome‐based interventions provide emerging opportunities for precision diagnosis, ecological restoration, and ...
Xu Liu +11 more
wiley +1 more source
Levels of α-defensins 1-3 produced by imMDDC from HIV-infected individuals.
, 2013 (A) Comparison between the secreted levels of α-defensins 1-3 by imMDDC from HIV-controllers (elite controllers and viremic controllers; n = 19) and HIV non-controllers (viremic non-controllers and patients with HAART; n = 20).
Marta Rodríguez-García (111850) +8 more
core +1 more source
PLoS Pathogens, 2014 Human α-defensins are potent anti-microbial peptides with the ability to neutralize bacterial and viral targets. Single alanine mutagenesis has been used to identify determinants of anti-bacterial activity and binding to bacterial proteins such as ...
Victoria R Tenge +4 more
doaj +1 more source
Integrative Zoology, EarlyView.Juvenile Procambarus clarkii exposed to noise exhibited behavioral changes, shifts in enzymatic activity, and altered expression of stress and immune genes. The findings highlight the sensitivity of invertebrate juveniles to anthropogenic acoustic pollution.
Maria Ceraulo +8 more
wiley +1 more source
Expression of Antimicrobial Defensins in the Male Reproductive Tract of Rats, Mice, and Humans
, 2003 International audienceDefensins are antimicrobial peptides that play a major role in innate immunity. Using reverse transcriptase-polymerase chain reaction, immunochemistry, or both, we performed a search of all presently known defensins in rat testis ...
Tomas Ganz +13 more
core +1 more source
Integrative Zoology, EarlyView.ABSTRACT The increasing frequency and intensity of heatwaves—extreme thermal events characterized by prolonged supra‐optimal temperatures—exert profound impacts on global ecosystem stability and species interactions. While the disruptive effects of thermal stress on host physiology and gut microbiota are well documented, the role of cuticular ...
Jiyu Wu +3 more
wiley +1 more source
, 2017 Paneth cell α-defensins are antimicrobial peptides involved in the control of the intestinal microbiota and immunological homeostasis. In mice, they are encoded by multiple, highly homologous genes (Defa). The transcriptional activity of ileal Defa genes
Willing B.P. (4134427) +7 more
core +1 more source
Serum‐Proteomic Profiling Reveals Distinct Atopic Dermatitis Severity‐Linked Signatures
Allergy, EarlyView.This study aimed to identify a set of serum biomarkers that robustly distinguish prespecified severe from mild atopic dermatitis groups. Serum proteomic profiling distinguishes severe from mild atopic dermatitis, revealing an epithelial enriched severity footprint linked to LDH‐associated tissue injury and Th2/Th22 inflammation.
Jag S. Lally +6 more
wiley +1 more source
Productive Folding of Human Neutrophil α-Defensins in Vitro without the Pro-peptide
, 2016 Human neutrophil α-defensins (HNPs) are small, Cys-rich, cationic antimicrobial proteins. Stored in the azurophilic granules of neutrophils, they are released during phagocytosis to kill ingested foreign microbes through disruption of their cytoplasmic ...
Robert Powell (2991465) +2 more
core +2 more sources
Andrology, EarlyView.ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam +7 more
wiley +1 more source