Results 61 to 70 of about 999,551 (181)
Research progress on biological function of mammalian defensins
Siliao yanjiu, 2023 Mammalian defensin is a kind of cationic polypeptide. It can be divided into α-defensin, β-defensin, and θ-defensin according to structural differences.
ZHAO Feng +3 more
doaj
Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies
Medicinal Research Reviews, EarlyView.ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva +23 more
wiley +1 more source
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Artificial protein design enables the creation of stable scaffolds beyond those evolved in nature. Incorporation of native functional motifs into de novo scaffolds provides a promising strategy to mimic natural interactions while altering structural frameworks.
Hakuto Miyoshi +7 more
wiley +1 more source
Revealing the Properties of Plant Defensins through Dynamics
Molecules, 2013 Defensins are potent, ancient natural antibiotics that are present in organisms ranging from lower organisms to humans. Although the structures of several defensins have been well characterized, the dynamics of only a few have been studied.
Fabio C. L. Almeida +2 more
doaj +1 more source
Proteinase 3 carries small unusual carbohydrates and associates with αlpha-defensins
, 2012 The neutrophil granulocyte is an important first line of defense against intruding pathogens and it contains a range of granules armed with antibacterial peptides and proteins.
Morten Zoega +9 more
core +1 more source
Virology Journal, 2006 Background Epithelial defensins including human β-defensins (hBDs) and α-defensins (HDs) are antimicrobial peptides that play important roles in the mucosal defense system.
Chong Kong T +5 more
doaj +1 more source
Responsive Materials, EarlyView.Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan +8 more
wiley +1 more source
Defensins: Potential Effectors in Autoimmune Rheumatic Disorders
, 2011 Defensins are small cationic peptides with antimicrobial properties. They constitute a highly conserved innate immune defense mechanism across species. Based on the arrangement of disulfide-bonds, α- and β-defensins are distinguished in humans.
Matthias Schneider, Stefan Vordenbäumen
core +1 more source
Human antimicrobial peptides in autoimmunity
Autoimmunity, 2020 Antimicrobial peptides (AMPs) were firstly discovered as cytotoxic substances that killed bacteria. Later they were described as biologically active peptides that are able not only to kill invaders but also to modulate host immunity. In particular, it is
Ekaterina S. Umnyakova +4 more
doaj +1 more source
A new strategy to produce a defensin: stable production of mutated NP-1 in nitrate reductase-deficient Chlorella ellipsoidea. [PDF]
PLoS ONE, 2013 Defensins are small cationic peptides that could be used as the potential substitute for antibiotics. However, there is no efficient method for producing defensins.
Li-Li Bai +10 more
doaj +1 more source