Results 41 to 50 of about 999,551 (181)

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Essential Role of IFN-γ in Regulating Gut Antimicrobial Peptides and Microbiota to Protect Against Alcohol-Induced Bacterial Translocation and Hepatic Inflammation in Mice

Frontiers in Physiology, 2021
The mechanisms by which alcohol provokes bacterial translocation in the development of alcoholic liver disease (ALD) remain incompletely defined. Our previous study demonstrates that impaired gut epithelial antimicrobial defense is critically involved in
Ruichao Yue, Xiaoyuan Wei, Jiangchao Zhao, Zhanxiang Zhou, Zhanxiang Zhou, Wei Zhong, Wei Zhong   +6 more
doaj   +1 more source

Alpha-defensin binding expands human adenovirus tropism.

PLoS Pathogens
Mammalian α-defensins are a family of abundant effector peptides of the mucosal innate immune system. Although primarily considered to be antimicrobial, α-defensins can increase rather than block infection by certain prominent bacterial and viral ...
Cheng Zhao, Jessica M Porter, Phillip C Burke, Niklas Arnberg, Jason G Smith   +4 more
doaj   +1 more source

Research progress on anti-mycobacterial effect of mammal defensins

Siliao yanjiu, 2022
Mammalian defencins are cationic peptides with antimicrobial activity produced by a variety of cells. They are divided into α-defencins, β-defencins and θ-defencins, which exert antimicrobial effects mainly by increasing the permeability of bacterial ...
KANG Jing-jing, ZHANG Xue-ming, SHI Zhi-fang, LUO Qin, WANG Lao-qi, WU Yu-chen   +5 more
doaj  

Key Determinants of Human α-Defensin 5 and 6 for Enhancement of HIV Infectivity

Viruses, 2017
Defensins are antimicrobial peptides important for mucosal innate immunity. They exhibit a broad spectrum of activity against bacteria, viruses, and fungi.
Kimyata Valere, Wuyuan Lu, Theresa L. Chang   +2 more
doaj   +1 more source

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

Advanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang   +15 more
wiley   +1 more source

Longitudinal Modulation of the Gut Microbiome and Growth Performance by Phytochemicals as Antibiotic Alternatives in Swine Production

Animal Research and One Health, EarlyView.
We conducted a longitudinal trial across nursery, growing, and finishing phases, showing that phytochemical supplementation as a potential antibiotic alternative reduced potential pathogens and promoted beneficial Lactobacillus amylovorus in the nursery phase, and enriched amino acid and carbohydrate metabolism pathways (prediction) during finishing ...
Ziyu Liu, Samantha Howe, Yang Tian, Alisun N. Watson, Jason E. Farrar, Christopher E. Randolph, Jaime Andrés Ángel Isaza, Álvaro José Uribe, Yan Huang, Michael Looper, Jiangchao Zhao, Tsungcheng Tsai   +11 more
wiley   +1 more source

Dying and necrotic neutrophils are anti-inflammatory secondary to the release of α-defensins [PDF]

, 2009
Neutrophils are recruited to sites of injury but their timely removal is thought to be vital to prevent exacerbating inflammation. In addition, the recognition of apoptotic cells by cells of the innate immune system provides potent anti-inflammatory and ...
Miles, K., Lu, W., Clarke, David J, Davidson, Donald J, Gray, Mohini, Sibinska, Z., Gray, M., Clarke, D.J., Lu, Wuyuan, Barr, Tom A, Beaumont, P.E., Miles, Katherine, Sibinska, Zaneta, Campopiano, Dominic J, Barr, T.A., Beaumont, Paula E, Davidson, D.J., Campopiano, D.J.   +17 more
core   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

129 mouse α-defensins exhibit diminished antimicrobial activity against pro-inflammatory E. coli strains.

, 2012
(A) AU-PAGE was used to generate α-defensin profiles from B6 and 129 mice. The α-defensin region was excised and overlaid onto E.coli-laden agarose. (B) Zones of bacterial inhibition were detected for both NC101 (upper) and LF82 (lower) E.
Ajay S. Gulati (158270), Christian Jobin (74703), Emily Grossniklaus (181340), Michael T. Shanahan (181331), R. Balfour Sartor (146159), Janelle C. Arthur (143340), Richard J. von Furstenberg (181346), Lieselotte Kreuk (181348), Susan J. Henning (114358)   +8 more
core   +1 more source