Results 31 to 40 of about 999,551 (181)
Biosynthesis and Antimicrobial Evaluation of Backbone-Cyclized α-Defensins
, 2016 Defensins are antimicrobial peptides that are important in the innate immune defense of mammals. Upon stimulation by bacterial antigens, enteric α-defensins are secreted into the intestinal lumen where they have potent microbicidal activities. Cryptdin-4
Kenneth P. Tai (2140228) +5 more
core +1 more source
FOXO inhibition rescues α-defensin expression in human intestinal organoids [PDF]
, 2023 To mediate critical host-microbe interactions in the human small intestine, Paneth cells constitutively produce abundant levels of α-defensins and other antimicrobials.
Bevins, Charles L +6 more
core +1 more source
Frontiers in Immunology, 2020 Persistent infection with high-risk human papillomavirus (hrHPV) genotypes results in a large number of anogenital and head and neck cancers worldwide. Although prophylactic vaccination coverage has improved, there remains a need to develop methods that ...
Joseph G. Skeate +11 more
doaj +1 more source
Virucidal activity of human α- and β-defensins against hepatitis C virus genotype 4
, 2016 Hepatitis C virus (HCV) is the major etiological agent of human non-A and non-B hepatitis affecting about 180 million people worldwide. The goal of the current study was to find effective anti-HCV proteins.
Uversky, Vladimir N. +7 more
core +1 more source
Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry
Viruses, 2021 Innate immunity during acute infection plays a critical role in the disease severity of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), and is likely to contribute to COVID-19 disease outcomes.
Chuan Xu +10 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
mBio, 2017 α-Defensins are an important class of abundant innate immune effectors that are potently antiviral against a number of nonenveloped viral pathogens; however, a common mechanism to explain their ability to block infection by these unrelated viruses is ...
Mayim E. Wiens, Jason G. Smith
doaj +1 more source
Human Defensins: Potential Tools for Clinical Applications
, 2012 As components of the innate immune system, antimicrobial peptides in the form of human defensins play an important role in host defense by serving as the epithelial layer’s biochemical barrier against local infections.
Matthias Wenghoefer, Jochen Winter
core +1 more source
I-FABP as biomarker for the early diagnosis of acute mesenteric ischemia and resultant lung injury.
PLoS ONE, 2014 Acute mesenteric ischemia (AMI) is a life-threatening condition that can result in multiple organ injury and death. A timely diagnosis and treatment would have a significant impact on the morbidity and mortality in high-risk patient population.
Rachel G Khadaroo +5 more
doaj +1 more source