Results 21 to 30 of about 999,551 (181)

Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments. [PDF]

Proc Natl Acad Sci U S A, 2019
Antimicrobial peptides, in particular α-defensins expressed by Paneth cells, control microbiota composition and play a key role in intestinal barrier function and homeostasis.
Ehmann D, Wendler J, Koeninger L, Larsen IS, Klag T, Berger J, Marette A, Schaller M, Stange EF, Malek NP, Jensen BAH, Wehkamp J.   +11 more
europepmc   +2 more sources

DEFENSINS-a AT AN EARLY AGE IN RATS WITH ACUTE SOMATIC PAIN

RUDN Journal of Medicine, 2019
This article presents the results of studies on the reaction of α-defensins to acute somatic pain in newborn rats and in the early puberty period. Studies were carried out on white mongrel rats for three hours after pain exposure.
I. M. Bykov, V. V. Alekseev
doaj   +1 more source

Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn’s disease model mice

Life Science Alliance, 2020
This study provides novel insight into Crohn’s disease where α-defensin misfolding resulting from excessive ER stress in Paneth cells induces dysbiosis and disease progression.
Yu Shimizu, Kiminori Nakamura, Aki Yoshii, Yuki Yokoi, Mani Kikuchi, Ryuga Shinozaki, Shunta Nakamura, Shuya Ohira, Rina Sugimoto, Tokiyoshi Ayabe   +9 more
doaj   +1 more source

Alpha-defensin-dependent enhancement of enteric viral infection.

PLoS Pathogens, 2017
The small intestinal epithelium produces numerous antimicrobial peptides and proteins, including abundant enteric α-defensins. Although they most commonly function as potent antivirals in cell culture, enteric α-defensins have also been shown to enhance ...
Sarah S Wilson, Beth A Bromme, Mayumi K Holly, Mayim E Wiens, Anshu P Gounder, Youngmee Sul, Jason G Smith   +6 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Cyclic Peptides as Novel Therapeutic Microbicides: Engineering of Human Defensin Mimetics

Molecules, 2017
Cyclic peptides are receiving significant attention thanks to their antimicrobial activity and high serum stability, which is useful to develop and design novel antimicrobial agents.
Annarita Falanga, Ersilia Nigro, Margherita Gabriella De Biasi, Aurora Daniele, Giancarlo Morelli, Stefania Galdiero, Olga Scudiero   +6 more
doaj   +1 more source

FABP4 in Paneth cells regulates antimicrobial protein expression to reprogram gut microbiota

Gut Microbes, 2022
Antimicrobial proteins possess a broad spectrum of bactericidal activity and play an important role in shaping the composition of gut microbiota, which is related to multiple diseases such as metabolic syndrome.
Xiaomin Su, Mengli Jin, Chen Xu, Yunhuan Gao, Yazheng Yang, Houbao Qi, Qianjing Zhang, Xiaorong Yang, Wang Ya, Yuan Zhang, Rongcun Yang   +10 more
doaj   +1 more source

Modulation of host antimicrobial peptide (beta-defensins 1 and 2) expression during gastritis [PDF]

, 2002
Background: beta-Defensins are a newly identified family of antimicrobial peptides that are expressed by epithelia on mucosal surfaces where their production is augmented by infection or inflammation.
Domizio, P., Bajaj-Elliott, M., Ali, R.S., Domizio, P, Maher, L, Fedeli, P, Farthing, MJG, Fedeli, P., M Bajaj-Elliot (16115810), Quinn, AG, Smith, G.V, Quinn, A.G., Ali, RS, P Domizio (16116209), M J Farthing (16115624), Bajaj-Elliott, M, Maher, L., Farthing, M.J.G., P Fedeli (16116206), R S Ali (16116212), Smith, GV, R G Quinn (16116215), G V Smith (16115678), L Maher (9856208)   +23 more
core   +1 more source

Phosphoethanolamine Transferase LptA in Haemophilus ducreyi Modifies Lipid A and Contributes to Human Defensin Resistance In Vitro. [PDF]

PLoS ONE, 2015
Haemophilus ducreyi resists the cytotoxic effects of human antimicrobial peptides (APs), including α-defensins, β-defensins, and the cathelicidin LL-37.
Michael P Trombley, Deborah M B Post, Sherri D Rinker, Lorri M Reinders, Kate R Fortney, Beth W Zwickl, Diane M Janowicz, Fitsum M Baye, Barry P Katz, Stanley M Spinola, Margaret E Bauer   +10 more
doaj   +1 more source

Evolutionary trend of bovine β-defensin proteins toward functionality prediction: A domain-based bioinformatics study

Heliyon, 2023
Defensins are small cationic cysteine-rich and amphipathic peptides that form of three-dimensional β-strand structure connected by disulfide bonds. Defensins form key elements of the innate immune system of multicellular organisms.
Saiful Islam, Mst Rubaiat Nazneen Akhand, Mahmudul Hasan   +2 more
doaj   +1 more source