Results 11 to 20 of about 999,551 (181)

The repertoire of equine intestinal α-defensins [PDF]

BMC Genomics, 2009
Background Defensins represent an important class of antimicrobial peptides. These effector molecules of the innate immune system act as endogenous antibiotics to protect the organism against infections with pathogenic microorganisms. Mammalian defensins
Tetens Jens, Paul Sven, Bruhn Oliver, Thaller Georg   +3 more
doaj   +2 more sources

Elevated Concentration of Defensins in Hepatitis C Virus-Infected Patients [PDF]

Journal of Immunology Research, 2016
Hepatitis C virus (HCV) is the major etiological agent of human non-A and non-B hepatitis, affecting around 180 million people worldwide. Defensins, small cysteine-rich cationic peptides, are shown to have potent antibacterial, antiviral, and antifungal ...
Ehab H. Mattar, Hussein A. Almehdar, Abdullah A. AlJaddawi, Isam ElDin M. Abu Zeid, Elrashdy M. Redwan   +4 more
doaj   +2 more sources

Defensins Potentiate a Neutralizing Antibody Response to Enteric Viral Infection.

PLoS Pathogens, 2016
α-defensins are abundant antimicrobial peptides with broad, potent antibacterial, antifungal, and antiviral activities in vitro. Although their contribution to host defense against bacteria in vivo has been demonstrated, comparable studies of their ...
Anshu P Gounder, Nicolle D Myers, Piper M Treuting, Beth A Bromme, Sarah S Wilson, Mayim E Wiens, Wuyuan Lu, André J Ouellette, Katherine R Spindler, William C Parks, Jason G Smith   +10 more
doaj   +2 more sources

The Role of Defensins in HIV Pathogenesis

Mediators of Inflammation, 2017
Profound loss of CD4+ T cells, progressive impairment of the immune system, inflammation, and sustained immune activation are the characteristics of human immunodeficiency virus-1 (HIV-1) infection.
Barcley T. Pace, Andrew A. Lackner, Edith Porter, Bapi Pahar   +3 more
doaj   +2 more sources

A genome-wide screen identifies a single β-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins

BMC Genomics, 2004
Background Defensins comprise a large family of cationic antimicrobial peptides that are characterized by the presence of a conserved cysteine-rich defensin motif.
Xiao Yanjing, Hughes Austin L, Ando Junko, Matsuda Yoichi, Cheng Jan-Fang, Skinner-Noble Donald, Zhang Guolong   +6 more
doaj   +2 more sources

Role of defensins in immunothrombosis

Rheumatology & Autoimmunity
The interaction between innate immunity and coagulation is essential in thrombotic diseases, but the molecular links remain unclear. Neutrophils are key players, releasing mediators such as defensins, which are small cationic peptides with antimicrobial ...
Yuebing Wang, Guijuan Guo, Xiangjun Liu, Xiaoyu Chen, Wenqiong Wang, Patapong Towiwat, Ru Li, Chun Li   +7 more
doaj   +2 more sources

BLOOD CONTENTS OF DEFENSINS IN PATIENTS WITH PNEUMONIAS CAUSED BY INFLUENZA А/H1N1 [PDF]

Медицинская иммунология, 2014
. Defensin amounts in severe forms of influenza-associated pneumonia and acute respiratory distresssyndrome is increased to a lesser degree than in pneumonias with milder clinical course.
E. N. Romanova, A. V. Govorin, V. V. Gorbunov, S. A. Lukyanov   +3 more
doaj   +2 more sources

Defensins: The Case for Their Use against Mycobacterial Infections [PDF]

Journal of Immunology Research, 2016
Human tuberculosis remains a huge global public health problem with an estimated 1/3rd of the population being infected. Defensins are antibacterial cationic peptides produced by a number of cell types, most notably neutrophil granulocytes and epithelial
Haodi Dong, Yue Lv, Deming Zhao, Paul Barrow, Xiangmei Zhou   +4 more
doaj   +2 more sources

The Interplay between Defensins and Microbiota in Crohn’s Disease [PDF]

Mediators of Inflammation, 2017
Crohn’s disease (CD) is a chronic inflammation of the intestinal mucosa, characterized by periods of acute recurrence and remission. Depending on the specific region affected, CD is classified as ileal CD or colonic CD.
Lorena Coretti, Alessandro Natale, Mariella Cuomo, Ermanno Florio, Simona Keller, Francesca Lembo, Lorenzo Chiariotti, Raffaela Pero   +7 more
doaj   +2 more sources

Fecal α-defensins in GVHD [PDF]

, 2015
Background: Intestinal microbial ecology is actively regulated by Paneth cell-derived antimicrobial peptides, α-defensins. Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (SCT). We previously
Nakamura, K., Eriguchi, Y., K. Nakamura, D. Hashimoto, T. Teshima, Akashi, K., Shimono, N., Y. Eriguchi, T. Ayabe, Shimoda, S., Ayabe, T., Teshima, T., Hashimoto, D., S. Shimoda, K. Akashi, N. Shimono   +15 more
core   +1 more source