Results 221 to 230 of about 626,384 (268)

Mechanistic Study of Platelet Membrane‐Coated Resveratrol Nanosystem in Mitochondrial Dysfunction and Endothelial Senescence During Atherosclerotic Lesion Development via FOXM1 Activation

Aging Cell, Volume 25, Issue 8, August 2026.
Schematic diagram of the mechanism by which PM@RSV NPs alleviate AS via FOXM1 activation. ABSTRACT Atherosclerosis (AS) is closely linked to endothelial cell (EC) senescence and mitochondrial dysfunction, which impair vascular repair. Resveratrol (RSV) has antioxidant, anti‐inflammatory, and pro‐angiogenic effects, but its clinical use is restricted by
Li Xiao, Zexin Zhan, Ping Liu, Bing Qin
wiley   +1 more source

Unveiling the AcSirt2‐FOXO‐Mitophagy Axis: Insights Into Mitochondrial Quality Control and Delayed Aging in Apis cerana

Aging Cell, Volume 25, Issue 8, August 2026.
Age‐related downregulation of AcSirt2 impairs mitochondrial homeostasis in old bees. AcSirt2‐mediated deacetylation of FOXO enhances transcriptional activity, upregulating antioxidant enzymes (SOD, CAT) and promoting PINK1/Parkin‐mediated mitophagy. This pathway facilitates autophagosome formation and clearance of damaged mitochondria, reducing ROS ...
Qiang Ma, Zhengang Ma, Tingyue Huang, Qianmin Hai, Xiaoqun Dang, Jinshan Xu, Jialing Bao, Zachary Y. Huang, Zeyang Zhou   +8 more
wiley   +1 more source

Influence of diet nutrient density and a multicarbohydrase containing α-galactosidase on performance, carcass characteristics, breast myopathies, and nutrient utilization of broilers reared from 1 to 42 days of age. [PDF]

Poult Sci
Gulizia JP, Vargas JI, Bonilla SM, Hernandez JR, Almeida LM, Soster P, Thuekeaw S, Hutson B, Llamas-Moya S, Duong T, Pacheco WJ.   +10 more
europepmc   +1 more source

Diosgenin Alleviates Age‐Related Sarcopenia by Promoting Satellite Cell Proliferation and Myogenic Differentiation via Activation of the SIRT1/PGC‐1α Signaling Pathway

Aging Cell, Volume 25, Issue 8, August 2026.
As a critical bioactive component of Polygonatum sibiricum, diosgenin improves age‐related declines in skeletal muscle mass and function by activating the SIRT1/PGC‐1α pathway, upregulating the expression of the myokine METRNL and IGF‐1, and promoting satellite cell proliferation and myogenic differentiation.
Xin Zeng, Han Ding, Ziye Li, Qian Wang, Peiyao Guan, Tingting Wang, Jiayun Wang, Yansong Fu, Lizhang Chen, Hong Qin   +9 more
wiley   +1 more source

Safety evaluation of the food enzyme α-galactosidase from the genetically modified <i>Saccharomyces cerevisiae</i> strain CBS 615.94. [PDF]

EFSA J
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Lambré C, Barat Baviera JM, Bolognesi C, Cocconcelli PS, Crebelli R, Gott DM, Grob K, Lampi E, Mengelers M, Mortensen A, Rivière G, Steffensen IL, Tlustos C, Van Loveren H, Vernis L, Zorn H, Roos Y, Aguilera J, Andryszkiewicz M, Kovalkovicova N, Liu Y, Marini E, Chesson A.   +24 more
europepmc   +1 more source

Neurokinin‐1 receptor activation protects against cardiac fibrosis, inflammation and diastolic dysfunction in type 2 diabetic mice

British Journal of Pharmacology, Volume 183, Issue 15, Page 4246-4266, August 2026.
Background and Purpose The pathogenesis of type 2 diabetes mellitus (T2DM)‐induced cardiomyopathy involves cardiac fibrosis that leads to diastolic dysfunction. We established that replacement of lost substance P (SP) that occurs in T2DM reduces cardiac fibrosis and decreases inflammation in T2DM mice and non‐human primates.
Alexander Widiapradja, Heather Connery, Brody J. Helmick, Kallie J. Schafner, Vamsi Manchikalapudi, Hannah Horvath, Sophia Gugino, Tamas Kriska, Anja Herrnreiter, Evan DeVallance, William B. Campbell, Scott P. Levick   +11 more
wiley   +1 more source

Fluorogenic Coupled Assays Reveal Catalytic Properties, Inhibition Constants and Cellular Location of Mucin‐Active Carbohydrate Sulfatases

Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.
We report plate‐based coupled assays to rapidly and quantitatively determine the activity and selectivity of mucin‐active carbohydrate sulfatases. This fluorogenic assay further enables inhibitor identification and allows determination of (sub‐)cellular location. ABSTRACT Sulfated glycans play a central role in human health and influence cell signaling,
Charles W. E. Tomlinson, Madouc D. Bergers, David N. Bolam, Ana S. Luis, Alan Cartmell, Zachary Armstrong   +5 more
wiley   +2 more sources

ERF transcription factor StPti5 is a regulator of endophyte community maintenance in potato

New Phytologist, Volume 251, Issue 3, Page 1344-1360, August 2026.
Summary We have recently identified an ethylene response factor, StPti5, as a susceptibility factor that negatively regulates immune responses to diverse pathogens. Here, we investigated the role of StPti5 in the processes involved in the colonization of potato with beneficial organisms.
Tjaša Lukan, Karmen Pogačar, Barbara Kraigher, Katja Stare, Teja Grubar Kovačič, Maja Zagorščak, Marko Petek, Polonca Stefanic, Anže Vozelj, Valentina Levak, Tjaša Mahkovec Povalej, Juan M. García, Maria J. Pozo, Eva Álvarez, José M. Franco‐Zorrilla, Maja Križnik, Špela Baebler, Ines Mandić‐Mulec, Kristina Gruden   +18 more
wiley   +1 more source

α-Galactosidase and Sucrose-Kinase Relationships in a Bi-functional AgaSK Enzyme Produced by the Human Gut Symbiont Ruminococcus gnavus E1. [PDF]

Front Microbiol, 2020
Lafond M, Tauzin AS, Bruel L, Laville E, Lombard V, Esque J, André I, Vidal N, Pompeo F, Quinson N, Perrier J, Fons M, Potocki-Veronese G, Giardina T.   +13 more
europepmc   +1 more source

Highly Polygenic Control of Photosynthetic Responses to Nighttime Temperature Studied by Genomic Prediction

Plant, Cell &Environment, Volume 49, Issue 8, Page 5886-5903, August 2026.
ABSTRACT Rising nighttime temperature (Tnight) can reduce crop yields while low Tnight may restrict plant growth and development. Despite quantifiable effects of Tnight, genetic basis underlying plant responses to Tnight remains unclear. We investigated natural variation in long‐term response of effective photosynthetic efficiency (Fq’/Fm’) to Tnight ...
Ana Carolina dos Santos Sá, Alina Bazarova, Andreas Fischbach, Stefan Kesselheim, Benjamin Stich, Shizue Matsubara   +5 more
wiley   +1 more source