Results 1 to 10 of about 41,186 (264)

Serum α-Glucosidase Activity as a New Parameter of Negative Energy Balance in Dairy Cows [PDF]

Veterinary Sciences
Enzymes of the α-glucosidase group cleave α-D-glucose from the non-reducing end of short oligosaccharides. They contribute to carbohydrate digestion as maltase-glucoamylase in the intestinal brush border and as neutral α-glucosidase in other tissues ...
Babett Bartling, Thomas Tröbner, Lena Grone, Marion Schmicke   +3 more
doaj   +2 more sources

Exploring the inhibitory effect and mechanism of 3,4,5-trihydroxybiphenyl on α-glucosidase: an integrated experimental and computational approach [PDF]

Frontiers in Pharmacology
3,4,5-Trihydroxybiphenyl (THB) is a naturally occurring compound derived from Sorbus pohuashanensis, primarily reported for its antifungal activity. However, its potential to inhibit α-glucosidase remains unclear.
Ruofan Guo, Ruofan Guo, Guohua Yu, Yuan Li, Youyou Wang, Youyou Wang, Huixia Fan, Shuo Zhang, Chen Wang, Junhui Zhou, Junhui Zhou, Jian Yang, Jian Yang, Feng Gao, Feng Gao, Zhiqiang Luo   +15 more
doaj   +2 more sources

Advances in the natural α‐glucosidase inhibitors

eFood, 2023
α‐Glucosidase (AG) inhibitors, one of the classes of oral antidiabetics used to treat type 2 diabetes mellitus, delay digestion and absorption of glucose, which in turn, has a lowering effect on postprandial blood glucose and insulin levels.
Didem Şöhretoğlu, Gülin Renda, Randolph Arroo, Jianbo Xiao, Suat Sari   +4 more
doaj   +1 more source

Screening and functional evaluation of the glucose-lowering active compounds of total saponins of Baibiandou (Lablab Semen Album)

Digital Chinese Medicine, 2021
Objective: To screen for α-glucosidase inhibitor active compounds in the total saponins of Baibiandou (Lablab Semen Album) based on UHPLC-Q-Exactive Orbitrap MS technology and to evaluate its hypoglycemic activity in vivo.
Jun Han, Qinfang Zheng, Liangzi Fang, Xiaolong Huang   +3 more
doaj   +1 more source

α-glucosidase inMycoplasma mycoidessubspeciescapri [PDF]

FEMS Microbiology Letters, 1988
Mycoplasma mycoides subsp. capri utilisede maltose in medium lacking serum and hence serum saccharolytic enzymes. The presence of α-glucosidase activity was demonstrated by p-nitrophenyl-α-d-glucoside hydrolysis in toluene-treated cells. Specific activities were approx.
B.J. Wadher, R.J. Miles
openaire   +1 more source

β-Glucosidase from the cellulolytic system of Alternaria alternata autolyzed cultures [PDF]

FEMS Microbiology Letters, 1988
A β-glucosidase from centrifugated autolyzed cultures of Alternaria alternata has been purified 71 times by Sephadex G-200, CM-Biogel A and DEAE-Biogel A successively. The enzyme is a glycoprotein with 16% sugar and a Mr of 160 000, formed by two subunits of 60 000 and 80 000.
María Jesús Martínez, Covadonga Vázquez, Francisco Guillén, Fuensanta Reyes   +3 more
openaire   +1 more source

Design, synthesis, in vitro, and in silico biological evaluations of coumarin-indole hybrids as new anti-α-glucosidase agents

BMC Chemistry, 2022
Background A series of coumarin-indole hybrids was synthesized as the new α-glucosidase inhibitors. The title hybrids were considered as α-glucosidase inhibitors because had two active pharmacophores against α-glucosidase: coumarin and indole.
Davood Rezapour Niri, Mohammad Hosein Sayahi, Somayeh Behrouz, Ali Moazzam, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Bagher Larijani, Hossein Rastegar, Maryam Mohammadi-Khanaposhtani, Mohammad Mahdavi   +9 more
doaj   +1 more source

A constitutive, plasma-membrane bound β-glucosidase inTrichoderma reesei [PDF]

FEMS Microbiology Letters, 1986
Plasma membranes of Trichoderma reesei QM 9414, isolated from protoplasts by means of the concanavalin A procedure, contained β-glucosidase activity, which appeared constitutively upon growth on glucose. The enzyme had a pH optimum around 6, and was active on p-nitrophenyl-β-d-glucoside, cellobiose and sophorose (Km 0.7, 3.9 and 3.1 mM, respectively ...
Claudio Umile, Christian P. Kubicek
openaire   +1 more source

Synthesis of activity evaluation of flavonoid derivatives as ɑ-glucosidase inhibitors

Frontiers in Chemistry, 2022
Six flavonoid derivatives were synthesized and tested for anti-α-glucosidase activities. All derivatives were confirmed using NMR and HRMS and exhibited excellent inhibitory effects on α-glucosidase.
Hua Zhu, Xin Zhong
doaj   +1 more source

Purification and characterization of two extracellular β-glucosidases fromAspergillus nidulans [PDF]

FEMS Microbiology Letters, 1992
Two β-glucosidases, P-I and P-II, were purified from the culture filtrate of Aspergillus nidulans. The Mr values of P-I and P-II were about 125 000 and 50 000, respectively. The isoelectric point, optimal pH and temperature, Michaelis constants for several substrates and inhibition constants for glucose and glucono-δ-lactone of each enzyme were ...
Ki-Sun Kwon, Hyung Gyoo Kang, Yung Chil Hah   +2 more
openaire   +1 more source