Results 101 to 110 of about 1,767,652 (263)

Biochemical Studies and Production Optimization of β‐Glucosidase From Microcystis aeruginosa CACIAM 03 Using Organic Waste

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Global warming and industrial pollutants pose significant threats to environmental sustainability. In response, enzymes have emerged as promising tools for mitigating pollution. Enzymatic hydrolysis is considered environmentally sustainable due to its biological nature.
Gustavo Marques Serra, Matheus Silva da Fonseca Diniz, Evonnildo Costa Gonçalves, Agenor Valadares Santos, Luciana Pereira Xavier   +4 more
wiley   +1 more source

MOESM1 of Engineering a highly active thermophilic β-glucosidase to enhance its pH stability and saccharification performance

, 2016
Additional file 1. Effect of metal ions and chemical reagents on the activity of purified recombinant β-glucosidase Bgl3A.
Xia, Wei, Xinxin Xu, Lichun Qian, Pengjun Shi, Yingguo Bai, Huiying Luo, Ma, Rui, Yao, Bin   +7 more
openaire   +1 more source

Trends in the utilization, expenditure and costs of noninsulin glucose‐lowering drugs in the Medicaid population: Steady increases in glucagon‐like peptide‐1 receptor agonist and sodium–glucose transporter‐2 inhibitor use, prices and expenditure

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse changes in the utilization, expenditure and average cost of noninsulin glucose‐lowering drugs (GLDs) between 2008 and 2023. Methods This was a retrospective observational study of 2008–2023 data from the National Medicaid State Drug Utilization database.
Rawan O. Almadfaa
wiley   +1 more source

Coumarin linked to 2-phenylbenzimidazole derivatives as potent α-glucosidase inhibitors

Scientific Reports
α-Glucosidase inhibitors have emerged as crucial agents in the management of type 2 diabetes mellitus. In the present study, a new series of coumarin-linked 2-phenylbenzimidazole derivatives 5a–m was designed, synthesized, and evaluated as anti-α ...
Mina Sadeghi Ganjeh, Ali Mazlomifar, Ashraf Sadat Shahvelayti, Shiva Khalili Moghaddam   +3 more
doaj   +1 more source

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

Cloning and Expression of Marine α-Glucosidase and Its Preparation of High Purity Panose

Shipin gongye ke-ji
Panose is iso-malto-oligosaccharide contained α-1,6 glycosidic bonds, and α-glucosidase is the key enzyme to produce panose. In this study, the α-glucosidase gene in deep-sea hydrothermal vents thermophilic archaea Thermococcus siculi HJ21 was ...
Yiqun YU, Luzhou XUE, Hao NI, Lei JIANG, Xinxin KANG, Saikun PAN, Shujun WANG   +6 more
doaj   +1 more source

ISOLATION OF Α-GLUCOSIDASE INHIBITORY ACTIVE COMPOUNDS FROM ETHANOL EXTRACT OF KAYU TUAH (ANTIDESMA CELEBICUM MIQ.) LEAVES

International Research Journal of Pharmacy, 2015
Antidesma celebicum Miq . belongs to Euphorbiaceae family has been use d as antidiabetic traditional medic ine . The aim of the research was to isolate the α Glucosidase inhibitory compound from ethanol extract of Antidesma celebicum l eaves. The isolation have been done using column chromatography silica gel 60 and the structure was determinated base ...
Fajar Utami Novi, Elya Berna, Katrin .
openaire   +1 more source

Disentangling Sex Differences in Sulfonylurea Drug Response With Genome‐Wide Association Studies in Individuals With Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
A sex‐stratified genome‐wide association study of sulfonylurea response identified sex‐specific genetic loci associated with HbA1c reduction in individuals with type 2 diabetes. Replication and functional validation supported a male‐specific association at the TMEM64/NECAB1 locus, highlighting the potential of sex‐informed pharmacogenomics to advance ...
Joseph H. Breeyear, John S. House, Mark Kvale, Stella Nam, Farida S. Akhtari, Hetal S. Shah, Monique M. Hedderson, Kathleen M. Giacomini, Josyf C. Mychaleckyj, Alessandro Doria, Michael J. Wagner, Josephine H. Li, Sook Wah Yee, John B. Buse, Richard P. Woychik, Daniel M. Rotroff, Alison A. Motsinger‐Reif   +16 more
wiley   +1 more source

Inhibitory Mechanism of Aloe Emodin on α-Glucosidase and Synergistic Effect with Acarbose [PDF]

Shipin Kexue
In order to investigate the interaction between aloe emodin and α-glucosidase, enzyme kinetics, ultraviolet (UV) spectroscopy, infrared (IR) spectroscopy and fluorescence spectroscopy were employed to investigate the inhibitory mechanism of aloe emodin ...
QIN Chaofeng, LI Jiao, HAO Jingwen, BU Yaqin, LI Sheng, CHEN Naidong
doaj   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source