Results 111 to 120 of about 41,186 (264)

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source

Maltase 1 regulates DENV2 infection and life history in Aedes aegypti

Insect Science, EarlyView.
Our study employed CRISPR/Cas9 to generate a MAL1 knockout strain of Aedes aegypti, demonstrating that the absence of MAL1 significantly suppresses DENV2 replication in the midgut and impairs viral transmission. The mutation also altered life‐history (hatching/pupation/emerging rates and sex‐specific survival), identifying MAL1 as a novel target for ...
Man‐Jin Li, Jin Cheng, Ya‐Ming Zou, Quan‐Chao Liu, Ding Zhu, Ce‐Jie Lan   +5 more
wiley   +1 more source

A review on the in vitro and in vivo screening of α-glucosidase inhibitors

Heliyon
As a global metabolic disease, the control and treatment of diabetes have always been the focus of medical research. α-Glucosidase is a key enzyme in regulating blood glucose levels and has important applications in the treatment of diabetes. This review
Guangjuan Pan, Yantong Lu, Zhiying Wei, Yaohua Li, Li Li, Xiaojiao Pan   +5 more
doaj   +1 more source

MOESM1 of Proof of concept for the simplified breakdown of cellulose by combining Pseudomonas putida strains with surface displayed thermophilic endocellulase, exocellulase and β-glucosidase

, 2016
Additional file 1: Figure S1. Influence of MATE-fusion protein expression on the growth of P. putida. Grey: Cells without protein expression. Black: Cells expressing MATE-BglA (A), MATE-CelA (B) and MATE-CelK (C). Dashed lines depict the starting points of protein expression, which was induced by the addition of 0.2Â % l-arabinose.
Iasson Tozakidis, Brossette, Tatjana, Lenz, Florian, Maas, Ruth, Jose, Joachim   +4 more
openaire   +1 more source

TcALS knockdown accelerates metamorphosis via insulin signaling in Tribolium castaneum

Insect Science, EarlyView.
RNAi silencing of TcALS accelerates larva‐to‐pupa metamorphosis in Tribolium castaneum. Abstract Insect metamorphosis is an evolutionary adaptation precisely regulated by nutritional and hormonal cues. The red flour beetle Tribolium castaneum, a major stored‐product pest, serves as an excellent model for studying this process.
Min Li, Jie Chen, Zi‐Ye Wang, Fei‐Feng Wang, Lu‐Lu Dong, Jun Pan, Min‐Er Li, Lin Yu, Wen Sang   +8 more
wiley   +1 more source

Optimizing the Preparation Process and Antioxidant Activity of α-Glucosidase Inhibitory Peptide from Cinnamomum camphora Seed Kernel

Shipin gongye ke-ji
To achieve high-value development and use of the abundant Cinnamomum camphora seed resources in China and screen the α-glucosidase inhibitor peptides derived from Cinnamomum camphora seed kernel (CCSK), the aim of this study was to produce α-glucosidase ...
Weiyun WANG, Ningyao HAN, Yifang GAO, Ping YU, Zheling ZENG, Xianghui YAN   +5 more
doaj   +1 more source

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

Acta Ophthalmologica, EarlyView.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen, Jari Haukka, Tuomas Lilius, Sirpa Loukovaara   +3 more
wiley   +1 more source

Synthèses enzymatiques de néoglucoconjugués catalysées par l'alpha-glucosidase purifiée de la blatte Periplaneta americana (Linnaeus) [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2005
Enzymatic synthesis of neoglucoconjugates by purified α-glucosidase from cockroach Periplaneta americana (Linnaeus). Cockroach Periplaneta americana (Linnaeus) contains in his digestive tract an acid (pH 5,0) and mesophile (50°C) α-glucosidase.
Kamenan A., Kouamé FA., Niamké SL., Dué EA., Kouamé LP.   +4 more
doaj  

The Diagnostic Odyssey of a Biochemically Confirmed Case of ML II: The First Western Patient With LYSET Deficiency

Clinical Genetics, EarlyView.
We identify a female patient with a homozygous nonsense variant (p.Gln38Ter) in the LYSET gene. This is the first western report of a challenging case of an extensive diagnostic odyssey and demonstrates that the LYSET gene must be considered in the differential diagnosis when M6P‐labeled lysosomal enzymes are altered.
Fernanda Sperb‐Ludwig, Taciane Alegra, Leonardo Martinello da Rosa, Nataniel Floriano Ludwig, Renata Voltolini Velho, Ida Vanessa Doederlein Schwartz   +5 more
wiley   +1 more source

α-Glucosidase inhibitory activity of polyphenol-rich sugarcane extract: screening and mechanistic insights based on biolayer interferometry-mass spectrometry

Frontiers in Nutrition
IntroductionPolyphenol-rich sugarcane extract (PRSE) contains bioactive compounds with potential hypoglycemic properties, but its direct interaction with α-glucosidase has not been explored.MethodsThis study investigated the inhibitory mechanism of PRSE ...
Mengli Yao, Jia Liu, Fang Zhou, Haizhi Li, Ruoyong Wang, Zhong Han, Jie Liu, Wei Chen, Guoyu Liu, Shuheng Yang, Shenlin Duan, Xiaofeng Han, Peng Yuan   +12 more
doaj   +1 more source