Results 221 to 230 of about 42,943 (266)

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, Volume 183, Issue 16, Page 5082-5101, August 2026.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Bioactive Flavonoids from <i>Paulownia tomentosa</i> Flowers: Extraction Optimization and α-Glucosidase Inhibitory Kinetics. [PDF]

Foods
Jiang F, Yang H, Zhai X, Zhao Z, Fan G.
europepmc   +1 more source

Pentacyclic triterpenoids from <i>Ziziphus jujuba</i> Lamk. fruits as dual inhibitors of PTP1B and α-glucosidase: <i>in vitro</i> and <i>in silico</i> evaluations. [PDF]

RSC Adv
Tran L, Phan TT, Tran LVH, Nguyen MC, Vo HC, Tri Quang N, Huu Le PT, Mai QM, Thai KM, Tran HNK.   +9 more
europepmc   +1 more source

GIP in Cardiovascular and Kidney Disease: From Physiology to Pharmacology

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6509-6532, August 2026.
ABSTRACT Aims To provide a comprehensive overview of the cardiovascular and renal effects of glucose‐dependent insulinotropic polypeptide (GIP) by integrating its physiological role with recent human trial data on tirzepatide, the first dual GIP and glucagon‐like peptide‐1 (GLP‐1) receptor agonist.
Michelantonio De Fano, Line L. Haurum, Christine R. Schwarz, Francesca Porcellati, Andreas Andersen   +4 more
wiley   +1 more source

Structural and computational supported development of 2,5-disubstituted-1,3,4-oxadiazole analogues as active LOX, urease, and α-glucosidase inhibitors. [PDF]

Sci Rep
Javid J, Aziz-Ur-Rehman, Iqbal J, Ahmed I, Bhatti N, Kuznetsov A, Zafar F, Ayub MA, Mohammed OA, Al-Mijalli SH, Iqbal M, Shah SAA.   +11 more
europepmc   +1 more source

Primary cardiovascular preventive effect of thiazolidinedione in adults with type 2 diabetes: A nationwide cohort study in Korea

Journal of Diabetes Investigation, Volume 17, Issue 8, Page 1367-1378, August 2026.
Among Korean adults with type 2 diabetes and no prior cardiovascular disease, thiazolidinedione use was associated with a lower risk of the primary composite outcome of stroke, myocardial infarction, hospitalization for heart failure, and all‐cause mortality compared to dipeptidyl peptidase‐4 inhibitor use. ABSTRACT Background Thiazolidinediones (TZDs)
Yun Young Choi, Jimin Jeon, Minyoul Baik, Joonsang Yoo, Jinkwon Kim   +4 more
wiley   +1 more source

Peptides from 'Vaina Morada' Black Bean Inhibit α-Amylase and α-Glucosidase: A Combined In Silico-In Vitro Study. [PDF]

Foods
Ramirez-Lozano F, Contreras J, Alfaro-Diaz A, Luna-Vital DA, Mathis ACG, Urías-Silvas JE, Mojica L.   +6 more
europepmc   +1 more source

Design, synthesis, <i>in vitro</i>, and <i>in silico</i> studies on promising α-glucosidase inhibitors based on a quinazolinone-thiophene scaffold. [PDF]

RSC Adv
Baghershahi P, Dastyafteh N, Halimi M, Mohammadi-Khanaposhtani M, Ghafouri SN, Noori M, Ghasemi F, Mojtabavi S, Faramarzi MA, Torabi M, Alikhani M, Larijani B, Javanshir S, Mahdavi M.   +13 more
europepmc   +1 more source

Comparative metabolomics of acetylcholinesterase and α-glucosidase inhibitors in pericarp of Garcinia mangostana L. [PDF]

Bot Stud
Wang YH, Liu TW, Hsiao SW, Chu MH, Lee TH, Hsu SJ, Chen SY, Lee CK.   +7 more
europepmc   +1 more source