Results 251 to 260 of about 1,798,291 (314)

Rational design and synthesis of new acetamide-indole-benzo[d]imidazole-carboxylic acid hybrids as dual PTP1B/α-glucosidase inhibitors. [PDF]

RSC Adv
Dastyafteh N, Ghafouri SN, Mollazadeh M, Motamedi Shakib N, Halimi M, Hosseini S, Mojtabavi S, Faramarzi MA, Larijani B, Amanlou M, Mohammadi-Khanaposhtani M, Mahdavi M.   +11 more
europepmc   +1 more source

Comparative metabolomics of acetylcholinesterase and α-glucosidase inhibitors in pericarp of Garcinia mangostana L. [PDF]

Bot Stud
Wang YH, Liu TW, Hsiao SW, Chu MH, Lee TH, Hsu SJ, Chen SY, Lee CK.   +7 more
europepmc   +1 more source

Is scaffold hopping possible in machine learning using the electronic-structure-informatics (ESI) descriptor set? an application to natural-product-based drug discovery of α-glucosidase inhibitors. [PDF]

J Cheminform
Tateishi Y, Sugimoto M.
europepmc   +1 more source

Functional Analysis of Amino Acid Residues Responsible for Substrate Specificity of GH13_17 α‑Glucosidase from <i>Aedes aegypti</i> Saliva (AaMalI). [PDF]

ACS Omega
Auiewiriyanukul W, Saburi W, Mori H, Arthan D, Tharamak S.   +4 more
europepmc   +1 more source

Sustainable Synthesis of 1,2-Disubstituted Benzimidazoles as Promising α-Glucosidase Inhibitors: In Vitro and In Silico Evaluation. [PDF]

Pharmaceuticals (Basel)
Tocco G, Laus A, Manis C, Caboni P, Fais A, Era B.   +5 more
europepmc   +1 more source

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Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges.

European journal of medicinal chemistry, 2023
Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st century. It is a well-recognized multifactorial health problem contributes significantly to high mortality rates by causing serious health complications mainly ...
A. Mushtaq, Uzma Azam, Saba Mehreen, Muhammad Moazzam Naseer   +3 more
semanticscholar   +1 more source

Synthesis and biological evaluation of indole derivatives containing thiazolidine-2,4-dione as α-glucosidase inhibitors with antidiabetic activity.

European journal of medicinal chemistry, 2023
In order to develop potential α-glucosidase inhibitors with antidiabetic activity, twenty-six indole derivatives containing thiazolidine-2,4-dione were synthesized.
Chunmei Hu, Bingwen Liang, Jinping Sun, Jiangyi Li, Zhuang Xiong, Shao-Hua Wang, Xuetao Xu   +6 more
semanticscholar   +1 more source

Inhibition of starch digestion by phenolic acids with a cinnamic acid backbone: Structural requirements for the inhibition of α-amylase and α-glucosidase.

Food Chemistry, 2023
This study investigated the inhibition mechanism of cinnamic acid-based phenolic acids (cinnamic acid: CIA, 3,4-dimethoxy cinnamic acid: 3,4-mCIA, caffeic acid: CA, ferulic acid: FA) on starch digestion.
Meihui Yu, Song Zhu, Dejian Huang, Xiumei Tao, Yue Li   +4 more
semanticscholar   +1 more source

Inhibition mechanism of α-glucosidase inhibitors screened from Tartary buckwheat and synergistic effect with acarbose.

Food Chemistry, 2023
Tartary buckwheat has been shown to provide a good antihyperglycemic effect. However, it is unclear which active compounds play a key role in attenuating postprandial hyperglycemia.
Lin Han, Huiqing Wang, Junwei Cao, Yunlong Li, Xiying Jin, Caian He, Min Wang   +6 more
semanticscholar   +1 more source