Results 101 to 110 of about 975,489 (310)

Disentangling Sex Differences in Sulfonylurea Drug Response With Genome‐Wide Association Studies in Individuals With Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
A sex‐stratified genome‐wide association study of sulfonylurea response identified sex‐specific genetic loci associated with HbA1c reduction in individuals with type 2 diabetes. Replication and functional validation supported a male‐specific association at the TMEM64/NECAB1 locus, highlighting the potential of sex‐informed pharmacogenomics to advance ...
Joseph H. Breeyear, John S. House, Mark Kvale, Stella Nam, Farida S. Akhtari, Hetal S. Shah, Monique M. Hedderson, Kathleen M. Giacomini, Josyf C. Mychaleckyj, Alessandro Doria, Michael J. Wagner, Josephine H. Li, Sook Wah Yee, John B. Buse, Richard P. Woychik, Daniel M. Rotroff, Alison A. Motsinger‐Reif   +16 more
wiley   +1 more source

Synthesis, Biological Evaluation and Molecular Docking Study of 2-Substituted-4,6-Diarylpyrimidines as α-Glucosidase Inhibitors

Molecules, 2017
A novel series of 2-substituted-4,6-diarylpyrimidines 6a–6t has been synthesized, characterized by 1H-NMR, 13C-NMR and HRMS, and screened for in vitro α-glucosidase inhibitory activity.
Zipeng Gong, Zhenzhen Xie, Jie Qiu, Guangcheng Wang   +3 more
doaj   +1 more source

Influence of L-sorbose on the location of β-glucosidase in Trichoderma pseudokoningii [PDF]

FEMS Microbiology Letters, 1983
The effect of l-sorbose on growth, morphology, cell wall composition and β-glucosidase location has been examined with Trichoderma pseudokoningii. Sorbose-grown cultures exhibited a longer lag phase, a tendency to more frequent hyphal branching and showed a decreased cell wall content of β-1,3-glucan.
openaire   +1 more source

Molecular dynamics simulations reveal the inhibitory mechanism of Withanolide A against α-glucosidase and α-amylase

, 2023
Diabetes mellitus (DM) is a global chronic disease characterized by hyperglycemia and insulin resistance. The unsavory severe gastrointestinal side-effects of synthetic drugs to regulate hyperglycemia have warranted the search for alternative treatments ...
Mohd Hayrie, Mohd Hatta, Oyewusi, Habeebat Adekilekun, Safi, Sher Zaman, Kalaivani, Batumalaie, Wu, Yuan Seng *, Roswanira, Abdul Wahab   +5 more
core   +1 more source

Visible‐Light‐Mediated Synthesis of Biscoumarins Utilizing Photocaged Sulfonic Acid as the Catalyst

European Journal of Organic Chemistry, EarlyView.
A mild visible light approach for the synthesis of biscoumarins utilizing arylazo sulfones as the photoacid generator under 467 nm irradiation is introduced. Throughout the years, biscoumarin derivatives, known for their diverse biological properties, have attracted extensive synthetic interest.
Athina S. J. Shkembi, Stamatis K. Serviou, Valentina Benazzi, Maurizio Fagnoni, Stefano Protti, Christoforos G. Kokotos   +5 more
wiley   +1 more source

α‑Glucosidase and PTP-1B Inhibitors from Malbranchea dendritica

ACS Omega, 2021
Daniela Rebollar-Ramos, Berenice Ovalle-Magallanes, Juan Francisco Palacios-Espinosa, Martha Lydia Macías-Rubalcava, Huzefa A. Raja, Martín González-Andrade, Rachel Mata   +6 more
doaj   +1 more source

MOESM1 of A novel β-glucosidase from Saccharophagus degradans 2-40T for the efficient hydrolysis of laminarin from brown macroalgae

, 2018
Additional file 1: Table S1. Kinetic parametersa of Bgl1B in the hydrolysis of different types of substrates.
Kim, Dong, Kim, Do, Lee, Sang-Hyun, Kim, Kyoung   +3 more
openaire   +1 more source

Kinetics of Hypoglycemic α-Glucosidase Inhibitory Protein

, 2018
The activity of a-glucosidase enzyme (EC 3.2.1.20) was inhibited by 40.3% by an extracellular inhibitory protein which isolated from the culture filtrate of Aspergillus brasiliensis ATCC-16404. The maximum activity of this protein and fungal mycelial dry
Fahad A. Al-Dhabaan, Fahad Al-Dhabaan
core   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

β-Glucosidases in the yeastPichia polymorpha [PDF]

FEMS Microbiology Letters, 1979
T.G. Villa, V. Notario, J.R. Villanueva
openaire   +1 more source