Results 31 to 40 of about 1,551,967 (375)

Pomegranate ellagitannins inhibit α-glucosidase activity in vitro and reduce starch digestibility under simulated gastro-intestinal conditions [PDF]

, 2014
Pomegranate extract was tested for its ability to inhibit α-amylase and α-glucosidase activity. Pomegranate extract strongly inhibited rat intestinal α-glucosidase in vitro whereas it was a weak inhibitor of porcine α-amylase. The inhibitory activity was
BELLESIA, ANDREA, TAGLIAZUCCHI, Davide, VERZELLONI, Elena   +2 more
core   +1 more source

Inhibitory Effect of Polyphenols from the Whole Green Jackfruit Flour against α-Glucosidase, α-Amylase, Aldose Reductase and Glycation at Multiple Stages and Their Interaction: Inhibition Kinetics and Molecular Simulations

Molecules, 2022
For the first time, α-glucosidase, α-amylase, aldose reductase, and glycation at multiple stages inhibitory assays were used to explore the antidiabetic potential of whole unripe jackfruit (peel with pulp, flake, and seed).
Tejaswini Maradesha, Shashank M. Patil, K. Al-Mutairi, R. Ramu, SabbaRao V. Madhunapantula, Taha Alqadi   +5 more
semanticscholar   +1 more source

Synthesis and Molecular Docking Studies of Alkoxy- and Imidazole-Substituted Xanthones as α-Amylase and α-Glucosidase Inhibitors

Molecules, 2023
Current antidiabetic drugs have severe side effects, which may be minimized by new selective molecules that strongly inhibit α-glucosidase and weakly inhibit α-amylase.
Dolores G. Aguila-Muñoz, Gabriel Vázquez-Lira, Erika Sarmiento-Tlale, María C. Cruz-López, Fabiola E. Jiménez-Montejo, Víctor E. López y López, Carlos H. Escalante, Dulce Andrade-Pavón, Omar Gómez-García, Joaquín Tamariz, Aarón Mendieta-Moctezuma   +10 more
doaj   +1 more source

Design, Synthesis, In Silico Testing, and In Vitro Evaluation of Thiazolidinone-Based Benzothiazole Derivatives as Inhibitors of α-Amylase and α-Glucosidase

Pharmaceuticals, 2022
In this study, a stepwise reaction afforded thiazolidinone-based benzothiazole derivatives 1–15, and the synthesized derivatives were then screened for biological significance and found to be the leading candidates against α-amylase and α-glucosidase ...
Shoaib Khan, Shahid Iqbal, Marwa Khan, W. Rehman, Mazloom Shah, R. Hussain, Liaqat Rasheed, Yousaf Khan, A. Dera, R. Pashameah, Eman Alzahrani, Abd‐ElAziem Farouk   +11 more
semanticscholar   +1 more source

Synthesis and Biological Evaluation of 5-Fluoro-2-Oxindole Derivatives as Potential α-Glucosidase Inhibitors

Frontiers in Chemistry, 2022
α-Glucosidase inhibitors are known to prevent the digestion of carbohydrates and reduce the impact of carbohydrates on blood glucose. To develop novel α-glucosidase inhibitors, a series of 5-fluoro-2-oxindole derivatives (3a ∼ 3v) were synthesized, and ...
Jing Lin, Qi-Ming Liang, Yuan-Na Ye, Di Xiao, Li Lu, Meng-Yue Li, Jian-Ping Li, Yu-Fei Zhang, Zhuang Xiong, Na Feng, Chen Li   +10 more
doaj   +1 more source

The α-Amylase and α-Glucosidase Inhibition Capacity of Grape Pomace: A Review

Food and Bioprocess Technology, 2022
The concept of functional foods is gaining more importance due to its role in maintaining a healthy status and preventing some metabolic diseases. The control of diabetes, in particular type-2 (T2DM), could be considered a big challenge since it involves
Miluska Cisneros‐Yupanqui, A. Lante, D. Mihaylova, A. Krastanov, C. Rizzi   +4 more
semanticscholar   +1 more source

α-/β-Glucosidase and α-Amylase Inhibitory Activities of Roselle (Hibiscus sabdariffa L.) Ethanol Extract

MCBS (Molecular and Cellular Biomedical Sciences), 2017
Background: Diabetes mellitus is a metabolic disease, characterized by hyperglycemia due to disturbance in both insulin secretion and function. One of theurapeutic approaches is to reduce blood glucose levels by inhbiting α-/β-glucosidase and α-amylase ...
Marisca Evalina Gondokesumo, Hanna Sari Widya Kusuma, Wahyu Widowati   +2 more
doaj   +1 more source

In-Vitro α-Glucosidase Inhibitory Activities of Muntingia Calabura Linn.

International Journal of Engineering & Technology, 2019
Muntingia calabura Linn. also known locally as “ceri kampung” is a plant of the family Elaeocarpaceae. The plant has been reported to possess several medicinal properties including reducing high blood pressure, lowering cholesterol level and controlling Type 2 diabetes.
N I.I. Nor Azman, N Hashim, R Ahmad
openaire   +2 more sources

Flavonoids with α-glucosidase inhibitory activities and their contents in the leaves of Morus atropurpurea [PDF]

, 2013
BACKGROUND: This study aims to isolate the α-glucosidase inhibitory compounds from mulberry leaves (Morus atropurpurea Roxb., Moraceae) and to develop an analytical method for quantification of the compounds.
Hin-Chu Hong, Qing-Wen Zhang, Song-Lin Li, Wen-Cai Ye, Xiao-Qi Zhang   +4 more
core   +1 more source

New quinoline-based triazole hybrid analogs as effective inhibitors of α-amylase and α-glucosidase: Preparation, in vitro evaluation, and molecular docking along with in silico studies

Frontiers in Chemistry, 2022
The 7-quinolinyl-bearing triazole analogs were synthesized (1d–19d) and further assessed in vitro for their inhibitory profile against α-amylase andα-glucosidase. The entire analogs showed a diverse range of activities having IC50 values between 0.80 ± 0.
Yousaf Khan, Shahid Iqbal, Mazloom Shah, Aneela Maalik, R. Hussain, Shoaib Khan, Imran H. Khan, R. Pashameah, Eman Alzahrani, Abd‐ElAziem Farouk, M. Alahmdi, H. S. Abd-Rabboh   +11 more
semanticscholar   +1 more source