Results 61 to 70 of about 1,551,967 (375)

Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes [PDF]

, 2016
The development of small molecule activity-based probes (ABPs) is an evolving and powerful area of chemistry. There is a major need for synthetically accessible and specific ABPs to advance our understanding of enzymes in health and disease.
Aerts, Johannes M F G, Boot, Rolf G, Codée, Jeroen D C, Davies, Gideon J, Florea, Bogdan I, Franke, Christian, Jiang, Jianbing, Kallemeijn, Wouter W, Kuo, Chi-Lin, Overkleeft, Herman S, van der Marel, Gijsbert A, van Meel, Eline, Wu, Liang   +12 more
core   +17 more sources

A method for in vivo evaluation of α-glucosidase inhibition using Drosophila

MethodsX, 2023
The development of α-glucosidase inhibitors is essential for the prevention of type II diabetes. Previous research has investigated in vitro inhibition using isolated α-glucosidase, which may not accurately reflect physical processes.
Nattapong Wongchum, Alongklod Tanomtong, Somchai Pinlaor, Chatmongkon Suwannapoom, Ananya Dechakhamphu   +4 more
doaj   +1 more source

Inhibitory Effect and Mechanism of Gallic Acid on α-Amylase and α-Glucosidase Activities [PDF]

Shipin Kexue, 2023
In this study, the inhibitory effect and mechanism of gallic acid on α-amylase and α-glucosidase were investigated in terms of inhibitory rates, inhibition kinetics, ultraviolet (UV) spectra, fluorescence spectra, circular dichroism (CD) spectra, and ...
SHEN Heyu, LI Mengyang, AO Jingfang, WANG Jun, XU Huaide, LUO Anwei
doaj   +1 more source

FLAVONOIDS FROM RHYNCHOSIA PSEUDO-CAJAN AS SUITABLE α-GLUCOSIDASE INHIBITORS AND FREE RADICAL SCAVENGERS

International Research Journal of Pharmacy, 2014
A series of nine flavonoids , 1 - 9, isolated from Rhynchosia pseudo - cajan Cambe ss., ha s been investigated in present work for their biological potential against α - glucosidase, lipoxygenase (LOX), acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes ; and antioxidant activity against diphenylpicrylhydrazyl (DPPH) radica l ...
Muhammad Athar Abbasi, Ghulam Hussain, Aziz ur Rehman, Viqar Uddin Ahmad   +3 more
openaire   +1 more source

Partial purification and biochemical characterization of a soluble α-glucosidase II-like activity fromCandida albicans [PDF]

FEMS Microbiology Letters, 2004
A soluble α-glucosidase was partially purified from Candida albicans cells by a three-step procedure consisting of size-exclusion, ion-exchange and adsorption chromatographies. After the last step, enzyme was enriched about 8.7-fold with a yield of 13% over the starting material and analysis of the purified preparation revealed two major polypeptides ...
María Eugenia Torre-Bouscoulet, Everardo López-Romero, Rosalía Balcázar-Orozco, Carlos Calvo-Méndez, Arturo Flores-Carreón   +4 more
openaire   +1 more source

Screening natural product extracts for potential enzyme inhibitors: protocols, and the standardisation of the usage of blanks in α-amylase, α-glucosidase and lipase assays

Plant Methods, 2021
Background Enzyme assays have widespread applications in drug discovery from plants to natural products. The appropriate use of blanks in enzyme assays is important for assay baseline-correction, and the correction of false signals associated with ...
Chintha Lankatillake, Shiqi Luo, Matthew Flavel, G. Lenon, Harsharn Gill, Tien Huynh, D. Dias   +6 more
semanticscholar   +1 more source

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

Natural Products and Bioprospecting
Diabetes mellitus remains a major global health issue, and great attention is directed at natural therapeutics. This systematic review aimed to assess the potential of flavonoids as antidiabetic agents by investigating their inhibitory effects on α ...
Thua-Phong Lam, Ngoc-Vi Nguyen Tran, Long-Hung Dinh Pham, Nghia Vo-Trong Lai, Bao-Tran Ngoc Dang, Ngoc-Lam Nguyen Truong, Song-Ky Nguyen-Vo, Thuy-Linh Hoang, Tan Thanh Mai, T. Tran   +9 more
semanticscholar   +1 more source

Design, synthesis, and in silico studies of quinoline-based-benzo[d]imidazole bearing different acetamide derivatives as potent α-glucosidase inhibitors

Scientific Reports, 2022
In this study, 18 novel quinoline-based-benzo[d]imidazole derivatives were synthesized and screened for their α-glucosidase inhibitory potential. All compounds in the series except 9q showed a significant α-glucosidase inhibition with IC50 values in the ...
Milad Noori, A. Davoodi, Aida Iraji, Navid Dastyafteh, Minoo Khalili, M. Asadi, Maryam Mohammadi Khanaposhtani, Somayeh Mojtabavi, M. Dianatpour, M. Faramarzi, B. Larijani, M. Amanlou, M. Mahdavi   +12 more
semanticscholar   +1 more source

Synthesis and α-Glucosidase Inhibitory Mechanisms of Bis(2,3-dibromo-4,5-dihydroxybenzyl) Ether, a Potential Marine Bromophenol α-Glucosidase Inhibitor

Marine Drugs, 2011
Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE), derived from the marine algae, is a potential α-glucosidase inhibitor for type 2 diabetes treatment.
Xiukun Lin, Jianteng Wei, Wei Zhang, Ming Liu   +3 more
doaj   +1 more source

A single supplement of a standardised bilberry (Vaccinium myrtillus L.) extract (36 % wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes controlled by diet and lifestyle [PDF]

, 2013
Peer reviewedPublisher ...
Bestwick, Charles, Cruickshank, Morven, Hoggard, Nigel, Holst, Jens J, Horgan, Graham, Moar, Kim-Marie, Russell, Wendy   +6 more
core   +1 more source