Design, eco-friendly synthesis, and molecular docking studies of isatin hybrids as promising therapeutic agents (anticancer, anticholinesterase inhibitor, α-glucosidase inhibitor, and anti-MRSA). [PDF]
RSC AdvSeliem IA.
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A Review of Current Computational Tools for Peptide–Protein Docking
Journal of Computational Chemistry, Volume 47, Issue 5, 15 February 2026.In this review, we compare 14 specialized peptide‐protein docking programs, adaptable small‐molecule docking tools, and emerging AI‐driven approaches. By clarifying how each method works, we offer researchers an accessible guide to selecting the most suitable tools for biochemical studies and peptide‐focused drug discovery.
Fábio G. Martins +2 more
wiley +1 more source
Liquidambaric acid as a non-competitive α-glucosidase inhibitor: multi-level evidence from enzyme kinetics, molecular docking, molecular dynamics simulations, and a <i>Drosophila</i> hyperglycaemic model. [PDF]
J Enzyme Inhib Med ChemJia L, Liu Y, Fu B, Tian Y, Meng X.
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A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, Volume 16, Issue 2, Page 365-381, February 2026.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
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<i>In vivo</i> anti-diabetic and anti-lipidemic evaluations of an excellent synthetic α-glucosidase inhibitor with dihydropyrano[3,2-c]quinoline skeleton. [PDF]
J Diabetes Metab DisordMohammadi-Khanaposhtani M +5 more
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Aggregate, Volume 7, Issue 2, February 2026.The integration of atomically precise gold nanoclusters with peptides or drugs represents a cutting‐edge class of nanomaterials in the biomedical field, owing to their unique physicochemical properties such as water solubility, excellent biocompatibility, low toxicity, and good renal clearance.
Rebeca Garcia Moura +2 more
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Molecular modeling approach in design of new scaffold of <b>α</b>-glucosidase inhibitor as antidiabetic drug. [PDF]
Biochem Biophys RepAmini F, Abbas KI, Ghasemi JB.
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Inverse Association Between Betel Quid Use and Diabetes in Rural Bangladesh
American Journal of Human Biology, Volume 38, Issue 2, February 2026.ABSTRACT Objectives Betel quid is used as a mild stimulant in many parts of South and East Asia and the Pacific. In observational studies, its use has been associated with elevated risk for diabetes, but studies in animal models suggest some component(s) of betel quid could reduce risk.
Kristin K. Sznajder +9 more
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Severe Acute Interstitial Nephritis Induced by α-glucosidase Inhibitor Miglitol in an Elderly Patient with Type 2 Diabetic Nephropathy. [PDF]
Intern MedOno K +8 more
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Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION The aim of this study was to investigate the cognitive and cerebrovascular outcomes of patients with hypertension (HTN) receiving various renin‐angiotensin system (RAS) inhibitors. METHODS We further categorized 39,665 patients with HTN receiving long‐term RAS inhibitor therapy into (1) telmisartan, (2) non‐telmisartan angiotensin
Chi‐Hung Liu +5 more
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