Results 181 to 190 of about 1,369,314 (252)

Constituents From the Flowers of Viburnum macrocephalum f. macrocephalum and Their α‐Amylase and α‐Glucosidase Inhibitory Activities

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Two new cadinane‑type sesquiterpenes, viburetones A and B, were isolated from Viburnum macrocephalum flowers, marking the first cadinane skeletons in this genus. Viburetone A showed dual α‑amylase and α‑glucosidase inhibition comparable to acarbose, and docking clarified its binding.
Ya‐Jiao Chen, Hong‐Juan Zhou, Xue‐Jing Zhu, Jia Chen, Jian‐Hua Shao, Chun‐Chao Zhao   +5 more
wiley   +1 more source

Synthesis, Characterization, and Multifunctional Bioactivity of ZnO/CuO@Amoxicillin Nanocomposites: A Synergistic Nano‐Platform With Potent Antioxidant, Anti‐Inflammatory, Antidiabetic, and Anti‐Cholinesterase Activities

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
ZnO/CuO@amoxicillin nanocomposite, synthesized via sol–gel route, demonstrates exceptional multifunctional performance. It strongly inhibits α‐amylase and α‐glucosidase, effectively suppresses inflammation, and exhibits superior antioxidant activity surpassing ascorbic acid.
Hocine Sadam Nesrat, Abdelatif Aouadi, Ibtissam Laib, Salah Eddine Laouini, Abderrhmane Bouafia, Djamila Hamada Saoud, Halima Zidane, Hafidha Terea, Mahmood M. S. Abdullah, Tomasz Trzepieciński, Dalila Saidane‐Mosbahi   +10 more
wiley   +1 more source

The efficacy of switching basal-bolus insulin therapy to basal insulin-supported oral therapy with a glinide and an α-glucosidase inhibitor in patients with type 2 diabetes depends on insulin secretory capacity, but not on blood glucose profiles and insulin dosages prior to the switching. [PDF]

Diabetol Int
Ando T, Kondo M, Asada-Yamada Y, Kawai M, Asano-Hayami E, Hayami T, Motegi M, Ejima Y, Nagao E, Kasagi R, Nakai-Shimoda H, Asano S, Kato M, Yamada Y, Yura-Miura E, Ishikawa T, Sugiura-Roth Y, Kojima C, Naito E, Himeno T, Tsunekawa S, Kato Y, Nakamura J, Kamiya H.   +23 more
europepmc   +1 more source

First Report on the Phytochemical and Pharmacological Properties of Hedysarum yilmazunalii

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Hedysarum yilmazunalii was collected from Erzincan, Türkiye. The leaf, stem, and root parts were then used for methanolic extraction. The extracts were analyzed for their phytochemical composition by LC–MS/MS and tested for antioxidant, enzyme inhibitory, and antiproliferative activities.
Etem Osma, Tuğçe Varol, Samed Şimşek, Sevgi Altın, Mustafa Abdullah Yılmaz, Ali Aydın, Müjgan Elveren, Ali Kandemir   +7 more
wiley   +1 more source

Sulfonamide‐Based 2‐Amino‐1,3,4‐Oxadiazole Derivatives as Dual Cholinesterase and Carbonic Anhydrase Inhibitors: Design, Synthesis, Kinetic Characterization, Molecular Modeling, and ADMET Evaluation

Drug Development Research, Volume 87, Issue 6, September 2026.
ABSTRACT In this study, 12 novel sulfonamide derivatives incorporating 2‐amino‐1,3,4‐oxadiazole and 1,3‐benzazol‐2(3H)‐one scaffolds were synthesized and structurally characterized using 1H NMR, 13C NMR, and LC–MS analyses. Their inhibitory activities were evaluated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase I
Gülnur Arslan Karahan, Başak Gökçe, Muhammed Tilahun Muhammed, Emre Kadir Ayan, Azime Berna Özçelik   +4 more
wiley   +1 more source

A cascade nanoreactor based on metal azolate framework integrated natural enzyme for α-glucosidase activity assay and inhibitor screening

Reviewed By Yoesoep Edhie Rachmad, A cascade nanoreactor based on metal azolate framework integrated natural enzyme for α-glucosidase activity assay and inhibitor screening Journal of Colloid and Interface Science 2025 | Journal article DOI: 10.1016/J ...
Prof. Dr. Yoesoep Edhie Rachmad, Ph.D, DBA
core  

Soil Microbial Assembly Mirrors a Savanna Mosaic Amid Plant Invasion and Soil Disturbance

Ecology and Evolution, Volume 16, Issue 9, September 2026.
Grasslands and woody patches supported distinct soil and microbial assemblages, consistent with differences in vegetation inputs and nutrient regimes. Grasslands exhibited relatively simple assembly patterns, with plant diversity closely associated with soil nutrients and comparatively homogeneous microbial communities.
Elizabeth A. Bowman, A. Peyton Smith, Aaron C. Rhodes, Robert M. Plowes, Lawrence E. Gilbert   +4 more
wiley   +1 more source

Effects of Oral Semaglutide on Dietary Intake and Body Composition in Japanese People With Type 2 Diabetes: A Prospective Observational Study in Clinical Practice

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
This prospective observational study evaluated changes in dietary patterns and body composition after 3 months of oral semaglutide treatment in people with Type 2 diabetes. Oral semaglutide was associated with reduced energy intake, salt intake and body fat while preserving handgrip strength.
Mika Sawada, Naoko Nakanishi, Masakazu Aihara, Kanako Ohkuma, Shoko Hamano, Yoshitaka Sakurai, Rie Sekine, Satoshi Usami, Toshimasa Yamauchi, Naoto Kubota   +9 more
wiley   +1 more source

Canagliflozin Increases Postprandial Total Glucagon-Like Peptide 1 Levels in the Absence of α-Glucosidase Inhibitor Therapy in Patients with Type 2 Diabetes: A Single-Arm, Non-randomized, Open-Label Study. [PDF]

Diabetes Ther, 2019
Osonoi T, Tamasawa A, Osonoi Y, Ofuchi K, Katoh M, Saito M.   +5 more
europepmc   +1 more source

Dipeptidyl Peptidase‐4 Inhibitors Associated Heart Failure Events in Adult Patients With Type‐2 Diabetes Mellitus Treated With Dipeptidyl Peptidase‐4 Inhibitors: A Systematic Review and Meta‐Analysis

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
DPP‐4 Inhibitors associated withheart failure events in patients with type‐2 diabetes. This study found statistically insignificant summary effect for all DPP‐4 inhibitors combined but found asignificant association of saxagliptin with heart failure events (RR = 1.24, 95% CI 1.05–1.47). Results are to be interpreted with caution.
Shishir Nepal, Shiva Prasad Nepal
wiley   +1 more source