Results 171 to 180 of about 1,369,314 (252)

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, Volume 41, Issue 10, Page 1105-1118, October 2026.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source

Severe Acute Interstitial Nephritis Induced by α-glucosidase Inhibitor Miglitol in an Elderly Patient with Type 2 Diabetic Nephropathy. [PDF]

Intern Med
Ono K, Masuda T, Ono Y, Hishida E, Yoshizawa H, Imai T, Satonaka H, Akimoto T, Nagata D.   +8 more
europepmc   +1 more source

Durability and Safety of Imeglimin as an Add‐On to DPP‐4 Inhibitors in Japanese Type 2 Diabetes: The 104‐Week FAMILIAR Trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9101-9111, October 2026.
ABSTRACT Aims To evaluate the long‐term efficacy and safety of imeglimin added to dipeptidyl peptidase‐4 (DPP‐4) inhibitors in Japanese patients with type 2 diabetes, focusing on glycemic durability and safety in elderly patients over 104 weeks. Materials and Methods This multicenter, randomized, placebo‐controlled trial comprised a 24‐week double ...
Masashi Shimoda, Takeshi Osonoi, Masahiro Iwamoto, Hideaki Kaneto, Kohei Kaku   +4 more
wiley   +1 more source

Role of the thiosugar ring in the inhibitory activity of salacinol, a potent natural α-glucosidase inhibitor. [PDF]

RSC Adv
Takashima K, Nakamura S, Nagayama M, Marumoto S, Ishikawa F, Xie W, Nakanishi I, Muraoka O, Morikawa T, Tanabe G.   +9 more
europepmc   +1 more source

Glycemic and Renal Effects of SGLT2 Inhibitors in Monogenic Diabetes: A Real‐World National Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9633-9643, October 2026.
ABSTRACT Aims Evidence regarding the efficacy and safety of sodium–glucose cotransporter 2 inhibitors (SGLT2i) in monogenic diabetes is limited. We evaluated real‐world metabolic, renal, and safety outcomes of SGLT2i therapy in adults with monogenic diabetes.
Estelle Audrain, Pierre Bel Lassen, Christine Bellanné‐Chantelot, Marie Christine Vantyghem, Hippolyte Dupuis, Tiphaine Vidal‐Trecan, Nicolas Chevalier, Danièle Dubois‐Laforgue, Sophie Lamothe, Camille Vatier, Orianne Villard, René Valéro, Claire Briet, Corinne Vigouroux, Cécile Ciangura, Chloé Amouyal   +15 more
wiley   +1 more source

Enzyme@Silicone: A Versatile Combo for Robust Synthetic Biocatalysis?

Advanced Synthesis &Catalysis, Volume 368, Issue 17, 1 September 2026.
Silicone‐based polymers are versatile materials for enzyme immobilization, offering unique advantages such as chemical inertness, thermal stability, and tunable morphology. This review highlights their applications in synthetic biocatalysis, from batch to continuous processes, and addresses key challenges such as mass transport limitations and ...
Marion B. Ansorge‐Schumacher
wiley   +1 more source

Diagnostic Odyssey of Atypical Long‐Chain 3‐Hydroxyacyl‐CoA Dehydrogenase Deficiency (LCHADD) Explained by Three Allelic Products From Two Pathogenic Variants

American Journal of Medical Genetics Part A, Volume 200, Issue 9, Page 2128-2135, September 2026.
ABSTRACT Long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency (LCHADD) is an autosomal recessive mitochondrial defect of long‐chain fatty acid β‐oxidation, caused by biallelic pathogenic variants in HADHA or HADHB. We report a 22‐year‐old male with an atypically mild presentation of LCHADD who was referred to the Undiagnosed Diseases Network (UDN ...
Yutaka Furuta, Lynette C. Rives, T. Andrew Burrow, Thomas A. Cassini, Rory J. Tinker, Amy K. Robertson, Kimberly M. Ezell, Rizwan Hamid, Joy D. Cogan, John A. Phillips III   +9 more
wiley   +1 more source

From Traditional Spice to Functional Ingredient: Phenolic Profile and Bioactive Properties of Sicilian Rhus coriaria L. Fruit

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The phenolic composition of Rhus coriaria fruits has been comprehensively characterized and linked to a variety of biological activities, including antioxidant, anti‐glycation, enzyme‐inhibitory, and cytoprotective effects. These findings highlight the functional potential of Sicilian sumac as a valuable source of health‐promoting phytochemicals ...
Katia Arena, Donatella Ambroselli, Roberto Laganà Vinci, Luigi Mondello, Luca Santi, Laura Dugo, Paola Dugo   +6 more
wiley   +1 more source

Sesquiterpene‐Rich Essential Oil From Magnolia officinalis Stem Bark: Chemical Composition, Biological Activities, and In Silico Approach

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The essential oil from Magnolia officinalis (M. officinalis) stem bark, rich in sesquiterpenes, exhibited multiple bioactivities including cytotoxic, antioxidant, α‐glucosidase inhibitory, anti‐inflammatory, and antimicrobial effects, which were further supported by molecular docking analysis.
Nguyen Thi Kim Thanh, Phan Hong Minh, Huynh Thi Ngoc Ni, Tran Quang Hai, Le The Hoai, Le Ba Vinh, Pham Minh Quan, Nguyen Dinh Luyen, Ninh The Son   +8 more
wiley   +1 more source

Proteinase inhibitor candidates for therapy of enzyme-inhibitor imbalances [PDF]

, 1992
Collins, John, Jochum, Marianne, Luisetti, M., Fritz, Hans, Travis, J., Grassi, C., Casali, L.   +6 more
core   +1 more source