Results 201 to 210 of about 33,378 (259)

Wild Prunus cerasifera Ehrh. Polyphenols Alleviate Hyperglycemia in Type 2 Diabetes Mellitus Mice via Modulating Gut Microbiota‐SCFAs‐PI3K/Akt/TBC1D4 Pathway

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
WPPE treatment significantly alleviated type 2 diabetes by improving SCFAs and gut microbiota composition and promoted glycogen synthesis by regulating the PI3K/AKT/TBC1D4 pathway. WPPE also improved liver function and reduced oxidative stress and inflammation. ABSTRACT Our previous work demonstrated that wild Prunus cerasifera Ehrh.
Xinpeng Cheng, Xing Xie, Shibo Luo, Quanyuan Xie, Haiyan Xiang, Chunyan Peng, Qiao Ding, Hongbing Fan, Wei Liu, Lu Zhang   +9 more
wiley   +1 more source

α‐Glucosidase Inhibitory Potential of Citrus reticulata Peel‐Derived Flavonoids—A Prelude for the Management of Type 2 Diabetes

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Flavonoids derived from Citrus reticulate peel inhibit α‐glucosidase activity, delaying carbohydrate digestion and reducing glucose absorption, thereby indicating their potential as functional food components for type 2 diabetes management. ABSTRACT α‐Glucosidase inhibitors (AGIs) are compounds used to treat type 2 diabetes (T2D) by preventing the ...
Itumeleng T. Baloyi, Ali H. Rabbad, Ntombenhle H. Gama, Samkelo Malgas   +3 more
wiley   +1 more source

Utilization of Walnut Male Flowers (Juglans regia L.) as a Functional Ingredient in Biscuits: Impacts on Dough Rheology, Nutritional Composition, Glycemic Response, and Sensory Attributes

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
This study investigated walnut male flowers (WFs) as a functional ingredient in biscuits. Replacing wheat flour with 0%–10% WFs enhanced dough viscoelasticity, increased protein and fiber content, and reduced the predicted glycemic index by up to 16%.
Guoshuang Qin, Yajing Li, Jian Sun, Zhenxing Wang, Jinggui Nie, Kin Weng Kong, Amin Ismail, Yongyu Si, Xuechun Zhang   +8 more
wiley   +1 more source

Associations of Albuminuria and Metabolic Syndrome Traits With Fracture Risk in Patients With Type 2 Diabetes: A Population‐Based Cohort Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Type 2 diabetes is associated with an increased risk of fragility fractures. While obesity may protect against fractures, individuals with type 2 diabetes often exhibit other metabolic syndrome (MetS) traits and albuminuria. We evaluated their roles and synergistic implications on incident fractures, stratified by obesity status ...
Xi Xiong, David T. W. Lui, Chengsheng Ju, Xiaodong Liu, Li Wei, Manju Chandran, Carlos K. H. Wong   +6 more
wiley   +1 more source

Loss of Beta‐Cell Identity and Function as a Mechanism of Secondary Failure of Sulfonylurea Therapy in Diabetes

MedComm, Volume 7, Issue 2, February 2026.
ABSTRACT Sulfonylureas, commonly used to treat type 2 diabetes (T2D), often lose effectiveness over time when used as monotherapy; however, the underlying mechanisms remain unclear. To investigate the mechanisms of sulfonylurea failure, glibenclamide‐releasing pellets were implanted in KK mice, a polygenic model that spontaneously develops T2D. KK mice
Sumit Patel, Zihan Yan, Maria S. Remedi
wiley   +1 more source

Preventive Effect of Powder Bergamot Juice (Citrus bergamia Risso & Poiteau) on Pathophysiological Processes of Renal Disease in an Experimental Western Diet Model

Molecular Nutrition &Food Research, Volume 70, Issue 3, 13 February 2026.
Excessive intake of sugars and fats contributes to obesity and renal dysfunction. Natural bioactive compounds, such as those found in bergamot (Citrus bergamia), have been studied for their protective potential. In an experimental rat model, bergamot supplementation reduced weight gain, improved kidney function, and decreased oxidative stress markers ...
Marina de Paula Salomé dos Santos, Juliana Silva Siqueira, Erika Tiemi Nakandakare‐Maia, Taynara Aparecida Vieira, Núbia Alves Grandini, Thiago Luiz Novaga Palacio, Luís Eduardo Sormani, Caíque Manentti Caccia, Jordanna Cruzeiro, Fabiane Valentini Francisqueti‐Ferron, Camila Renata Corrêa   +10 more
wiley   +1 more source

Polygonum cognatum Extract: Multitarget Anti‐inflammatory, Antidiabetic, and Epigenetic Modulation Properties

ChemistryOpen, Volume 15, Issue 2, February 2026.
Polygonum cognatum extracts exhibit strong antioxidant, anti‐inflammatory, antidiabetic, and antimicrobial activities. This study demonstrates, for the first time, histone deacetylase inhibitory activity, revealing epigenetic modulation potential.
Serhat Karaman, Yakup Budak, Elif Aktürk Bozdemir   +2 more
wiley   +1 more source

Design, synthesis, <i>in vitro</i>, and <i>in silico</i> studies on promising α-glucosidase inhibitors based on a quinazolinone-thiophene scaffold. [PDF]

RSC Adv
Baghershahi P, Dastyafteh N, Halimi M, Mohammadi-Khanaposhtani M, Ghafouri SN, Noori M, Ghasemi F, Mojtabavi S, Faramarzi MA, Torabi M, Alikhani M, Larijani B, Javanshir S, Mahdavi M.   +13 more
europepmc   +1 more source

Soil extracellular enzymes drive soil carbon accumulation under elevated CO2

Functional Ecology, Volume 40, Issue 2, Page 347-359, February 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Human‐driven increases in atmospheric CO2 (eCO2) are stimulating plant growth, thereby increasing the input of plant‐derived carbon into soils. The fate of this additional carbon depends on the capacity of soil microbiomes to decompose and transform organic matter, a ...
Yixuan Zhang, Siyi Sun, Jiacong Zhou, Kees Jan van Groenigen, Manuel Delgado‐Baquerizo, Ying Ma, Daryl L. Moorhead, Bruce A. Hungate, Pete Smith, César Terrer, Ji Liu, Robert L. Sinsabaugh, Liping Guo, Raúl Ochoa‐Hueso, Sally A. Power, Jørgen Eivind Olesen, Yiqi Luo, Junji Cao, Mingkai Jiang, Zhaozhong Feng, Min Luo, Ji Chen   +21 more
wiley   +1 more source

Butyrolactone-I, an efficient α-glucosidase inhibitor, improves type 2 diabetes with potent TNF-α-lowering properties through modulating gut microbiota in db/db mice.

FASEB J, 2019
Wu W, Liu L, Zhu H, Sun Y, Wu Y, Liao H, Gui Y, Li L, Liu L, Sun F, Lin H.   +10 more
europepmc   +1 more source