Results 51 to 60 of about 33,869 (259)

Design, synthesis, and in silico studies of quinoline-based-benzo[d]imidazole bearing different acetamide derivatives as potent α-glucosidase inhibitors

Scientific Reports, 2022
In this study, 18 novel quinoline-based-benzo[d]imidazole derivatives were synthesized and screened for their α-glucosidase inhibitory potential. All compounds in the series except 9q showed a significant α-glucosidase inhibition with IC50 values in the ...
Milad Noori, Ali Davoodi, Aida Iraji, Navid Dastyafteh, Minoo Khalili, Mehdi Asadi, Maryam Mohammadi Khanaposhtani, Somayeh Mojtabavi, Mehdi Dianatpour, Mohammad Ali Faramarzi, Bagher Larijani, Massoud Amanlou, Mohammad Mahdavi   +12 more
doaj   +1 more source

Antidiabetic and antioxidant properties of Ficus deltoidea fruit extracts and fractions [PDF]

, 2013
BACKGROUND: Diabetes is a serious metabolic disorder affecting the metabolism of carbohydrate, protein and fat. A number of studies have shown that diabetes mellitus is associated with oxidative stress, leading to an increased production of reactive ...
Azlina Abdul Aziz, Hasni Misbah, Norhaniza Aminudin   +2 more
core   +1 more source

Synthesis, Biological Evaluation and Molecular Docking Study of 2-Substituted-4,6-Diarylpyrimidines as α-Glucosidase Inhibitors

Molecules, 2017
A novel series of 2-substituted-4,6-diarylpyrimidines 6a–6t has been synthesized, characterized by 1H-NMR, 13C-NMR and HRMS, and screened for in vitro α-glucosidase inhibitory activity.
Zipeng Gong, Zhenzhen Xie, Jie Qiu, Guangcheng Wang   +3 more
doaj   +1 more source

The effect of sulfide on -glucosidases: implications for starch degradation in anaerobic bioreactors [PDF]

, 2007
Membrane associated α-glucosidase activity was investigated in a methanogenic bioreactor (MR) and a biosulfidogenic bioreactor (SR). Temperature and pH optima studies showed temperature optima of 50 °C and pH optima of 8.0 for the α-glucosidases from ...
Togo, C A, Wutor, V C
core   +2 more sources

Effects of Cellulase and Lactobacillus plantarum Supplementation on Fermentation Characteristics, In Situ Degradability, and Microbial Community Dynamics of Apple Pomace Silage

Animal Research and One Health, EarlyView.
This study aimed to investigate the effects of cellulase and Lactobacillus plantarum on the silage quality, in situ digestibility, and microbial communities of apple pomace silage. The combined supplementation of cellulase and Lactobacillus plantarum in apple pomace silage improved fermentation quality and enhanced rumen utilization efficiency.
Zhuangzhuang Liu, Xiongfei Zhang, Fengbo Sun, Junhu Yao, Xinjian Lei   +4 more
wiley   +1 more source

Advances in the synthesis of Homochiral (-)-1-azafagomine and (+)-5-epi-1-azafagomine. 1-N-phenyl carboxamide derivatives of both enantiomers of 1-azafagomine: leads for the synthesis of active α-Glycosidase inhibitors [PDF]

, 2011
- A new expeditious preparation of homochiral (-)-1-azafagomine, and (+)-5-epi-1-azafagomine has been devised. Stoodley´s diastereoselective cycloaddition of dienes bearing a 2,3,4,6-tetraacetyl glucosyl chiral auxiliary to 4-phenyl-1,2,4-triazole-3,5 ...
Alves, M. José, Costa, Flora Teixeira e, Duarte, Vera C. M., Fortes, A. Gil, Martins, J. A. R., Micaelo, N. M.   +5 more
core   +1 more source

The effect of pretreatment on VFA production from tofu and tempeh wastewater through anaerobic digestion batch

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Tofu and tempeh, derived from soybeans, are widely consumed for their nutritional value and high protein content. However, the production of these foods generates nutrient‐rich wastewater that poses environmental challenges while offering opportunities for valorization.
Lydia Mawar Ningsih, Mohammad J. Taherzadeh, Steven Wainaina, Hynek Roubík   +3 more
wiley   +1 more source

α-Amylase and α-Glucosidase Inhibition by Brown Seaweed (Sargassum sp) Extracts

Research Journal of Life Science, 2014
Inhibition of intestinal α-amylase and α-glucosidase is an important strategy to control post-prandial hyperglycemia associated with diabetes mellitus.
Muhammad Firdaus, Asep Awaludin Prihanto
doaj   +1 more source

New records of potent in-vitro antidiabetic properties of Dalbergia tonkinensis heartwood and the bioactivity-guided isolation of active compounds [PDF]

, 2018
[[abstract]]Alpha-glucosidase inhibitory activity has been commonly used for the evaluation of antidiabetic property in vitro. The aim of this study is to investigate and characterize Dalbergia tonkinensis as a potential source of antidiabetic compounds.
Aguiree, DeMelo, Fujita, Gerstein, McCue, Nguyen, Nguyen, Nguyen, Ninh, Ninh, Robert, Srivastava, Vasudeva   +12 more
core   +1 more source

Trends in the utilization, expenditure and costs of noninsulin glucose‐lowering drugs in the Medicaid population: Steady increases in glucagon‐like peptide‐1 receptor agonist and sodium–glucose transporter‐2 inhibitor use, prices and expenditure

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse changes in the utilization, expenditure and average cost of noninsulin glucose‐lowering drugs (GLDs) between 2008 and 2023. Methods This was a retrospective observational study of 2008–2023 data from the National Medicaid State Drug Utilization database.
Rawan O. Almadfaa
wiley   +1 more source