Results 81 to 90 of about 1,369,314 (252)

and α-Glucosidase Inhibitory Activity of Perfoliatin a from

Natural Product Communications, 2019
As part of our effort to discover new α-glucosidase inhibitors from natural sources, it was found that an aqueous extract from Melampodium perfoliatum (Cavanilles) Kunth (Asteraceae) inhibited the activity of rat-intestinal α-glucosidases in a ...
Laura Flores-Bocanegra, Rafael Torres-Colín, Martin González-Andrade, José S. Calderón, Rachel Mata   +4 more
doaj   +1 more source

α-Glucosidase and α-Amylase Inhibitors from Arcytophyllum thymifolium

, 2016
Three new coumarins (1-3), a prenylated flavanone (4), and two iridoids (5 and 6), together with 17 known secondary metabolites, were isolated from the aerial parts of Arcytophyllum thymifolium.
MILELLA, LUIGI, Immacolata Faraone, FARAONE, IMMACOLATA, Mariela Beatriz Vera Saltos, Lapillo, Margherita, Marinella De Leo, De Tommasi, Nunziatina, Milazzo, Stella, De Leo, Marinella, Margherita Lapillo, Stella Milazzo, Nunziatina De Tommasi, Alessandra Braca, Braca, Alessandra, Vera Saltos, Mariela Beatriz, Tuccinardi, Tiziano, Luigi Milella, Tiziano Tuccinardi   +17 more
core   +1 more source

Disentangling Sex Differences in Sulfonylurea Drug Response With Genome‐Wide Association Studies in Individuals With Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
A sex‐stratified genome‐wide association study of sulfonylurea response identified sex‐specific genetic loci associated with HbA1c reduction in individuals with type 2 diabetes. Replication and functional validation supported a male‐specific association at the TMEM64/NECAB1 locus, highlighting the potential of sex‐informed pharmacogenomics to advance ...
Joseph H. Breeyear, John S. House, Mark Kvale, Stella Nam, Farida S. Akhtari, Hetal S. Shah, Monique M. Hedderson, Kathleen M. Giacomini, Josyf C. Mychaleckyj, Alessandro Doria, Michael J. Wagner, Josephine H. Li, Sook Wah Yee, John B. Buse, Richard P. Woychik, Daniel M. Rotroff, Alison A. Motsinger‐Reif   +16 more
wiley   +1 more source

Sulfonamide chalcone as a new class of α-glucosidase inhibitors

, 2005
Chalcones 1-20, a new class of glycosidase inhibitors, were synthesized, and their glycosidase inhibitory activities were investigated. Non-aminochalcones 1-12 had no inhibitory activity, however, aminochalcones 13-20 had strong glycosidase (α ...
M S Yang, M J Curtis-Long, K H Park, J E Kang, Hyun Sun Lee, Hyung Won Ryu, W D Seo, J H Kim   +7 more
core   +1 more source

Visible‐Light‐Mediated Synthesis of Biscoumarins Utilizing Photocaged Sulfonic Acid as the Catalyst

European Journal of Organic Chemistry, EarlyView.
A mild visible light approach for the synthesis of biscoumarins utilizing arylazo sulfones as the photoacid generator under 467 nm irradiation is introduced. Throughout the years, biscoumarin derivatives, known for their diverse biological properties, have attracted extensive synthetic interest.
Athina S. J. Shkembi, Stamatis K. Serviou, Valentina Benazzi, Maurizio Fagnoni, Stefano Protti, Christoforos G. Kokotos   +5 more
wiley   +1 more source

Synthesis, DFT calculations, α‐glucosidase inhibitor activity, and docking studies on Schiff base metal complexes containing isothiocyanate

, 2023
Diabetes is one of the fastest growing global health crises of the 21st century. One of the current therapeutic approaches used in the treatment of diabetes involves the suppression of carbohydrate hydrolyzing enzymes such as α-glucosidase.
Adil Başoğlu, Davut Avcı, Avcı, Davut, Zengin Kurt, Belma, Yusuf Atalay, Fatih Sönmez, Özge, Özgen, Sönmez, Fatih, Atalay, Yusuf, Dege, Necmi, Necmi Dege, Başoğlu, Adil, Ömer Tamer, Belma Zengin Kurt, Tamer, Ömer, Özgen Özge   +15 more
core   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Stage‐Dependent Metabolic Reprogramming Drives a Self‐Organizing Microbial Network During Shanxi Aged Vinegar

Food Bioengineering, EarlyView.
Metabolic shifts from growth to stress adaptation in Shanxi aged vinegar fermentation link flavor maturation and microbial cooperation, and Lactobacillus and Acetobacter form a self‐organizing metabolic network through division of labor. ABSTRACT Acetic acid fermentation (AAF) is a vital stage in the production of Shanxi aged vinegar (SAV), during ...
Yanfang Wu, Jing Liu, Dantong Liu, Menglei Xia, Jia Song, Yu Zheng, Min Wang   +6 more
wiley   +1 more source

Fermentation‐Induced Modulation of Polyphenolic Contents and Medicinal Activities in Annona squamosa Seeds

Food Chemistry International, EarlyView.
The study compared the medicinal activities of polyphenols from fermented and unfermented seeds of Annona squamosa. The polyphenols were extracted and subjected to standard analysis. The major phenolic components of the fermented polyphenols and the unfermented polyphenols were found to be 4‐hydroxybenzoic and 4‐hydroxyphenylacetic acid, respectively ...
Shola Hezekiah Awojide, Abayomi Gideon Adeyemo, Christianah Dare, Oluseye Oladapo Abiona, Adedayo Olubunmi Adeboye, Omolara Oladipo‐Olalekan, Aminat Adebola Adeyemo, Yemisi Elizabeth Asibor, Emmanuel Oluwafemi Adeniyi, Bunmi Regina Bankole, Ezekiel Olumide Fadunmade   +10 more
wiley   +1 more source

1-Phenyl-β-carboline-3-carboxamide-1,2,3-triazole-N-phenylacetamide hybrids as new α-glucosidase inhibitors

Scientific Reports
In this work, 1-phenyl-β-carboline-3-carboxamide-1,2,3-triazole-N-phenylacetamide skeleton as a novel scaffold was designed based on hybridization of moieties that were found in the potent α-glucosidase inhibitors.
Elham Safaie, Mohammad Hosein Sayahi, Navid Dastyafteh, Mohammad Halimi, Milad Noori, Maryam Mohammadi-Khanaposhtani, Afsaneh Zonouzi, Roghieh Mirzazadeh, Azadeh Tajmir-Riahi, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Bagher Larijani, Mehdi Asadi, Mohammad Mahdavi   +13 more
doaj   +1 more source