Results 61 to 70 of about 7,137 (171)

Oxidative phosphorylation activation is an important characteristic of DOX resistance in hepatocellular carcinoma cells

Cell Communication and Signaling, 2018
Background Despite the implications for tumor growth and cancer drug resistance, the mechanisms underlying differences in energy metabolism among cells remain unclear.
Li Wu, Jiayu Zhao, Kexin Cao, Xiao Liu, Hao Cai, Jiaqi Wang, Weidong Li, Zhipeng Chen   +7 more
doaj   +1 more source

CD147 Facilitates the Pathogenesis of Psoriasis through Glycolysis and H3K9me3 Modification in Keratinocytes

Research, 2023
Psoriasis is a chronic inflammatory skin disease featuring rapid proliferation of epidermal cells. Although elevated glycolysis flux has been reported in psoriasis, the molecular mechanisms underlying its pathogenesis remain unclear.
Chao Chen, Xiaoqing Yi, Panpan Liu, Jie Li, Bei Yan, Detian Zhang, Lei Zhu, Pian Yu, Lei Li, Jiaxiong Zhang, Yehong Kuang, Shuang Zhao, Wu Zhu, Cong Peng, Xiang Chen   +14 more
doaj   +1 more source

Inhibitory Activity of Conferone on FAK Activity and Glutamine Metabolism in Human Colorectal Cancer

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Colorectal cancer (CRC) is a major global cause of death, with metastases and chemotherapy resistance contributing to poor outcomes. To identify natural compounds with anticancer potential against CRC and elucidate their action mechanisms, the cytotoxicity of 37 natural compounds was evaluated against the HCT116, leading to the identification ...
Hien Thi My Ong, Eda Ates, Jaeyong Jung, Jeong Soo Sung, Jae‐Chul Pyun, Min‐Jung Kang   +5 more
wiley   +1 more source

Metabolomic Analysis Reveals Contributions of Citric and Citramalic Acids to Rare Earth Bioleaching by a Paecilomyces Fungus. [PDF]

, 2019
Conventional methods for extracting rare earth elements from monazite ore require high energy inputs and produce environmentally damaging waste streams. Bioleaching offers a potentially more environmentally friendly alternative extraction process.
Alvarez-Cohen, Lisa, Brisson, Vanessa L, Zhuang, Wei-Qin   +2 more
core   +1 more source

PSAT1 Promotes NSCLC Progression via the De Novo Serine Synthesis Pathway and Represents a Therapeutic Vulnerability

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Background Non‐small cell lung cancer (NSCLC) is a malignant tumor characterized by high morbidity and mortality, as well as metabolic reprogramming. Enhanced serine synthesis plays a crucial role in the aberrant metabolism of NSCLC. Among the three key enzymes involved in serine synthesis, phosphoserine aminotransferase 1 (PSAT1) requires ...
Xijia Zhou, Min Zhao, Yingshu Cao, Xiangyu Zhou, Ke Wang   +4 more
wiley   +1 more source

The muscle metabolome differs between healthy and frail older adults [PDF]

, 2016
Populations around the world are aging rapidly. Age-related loss of physiological functions negatively affects quality of life. A major contributor to the frailty syndrome of aging is loss of skeletal muscle. In this study we assessed the skeletal muscle
Alves, Rodrigo D. A. M., Boekschoten, Mark V., de Groot, Lisette C.P.G.M., Fazelzadeh, Parastoo, Hangelbroek, Roland W. J., Muller, Michael, Smilde, Age K., Tieland, Michael, van Duynhoven, John P. M., van Loon, Luc J. C., Verdijk, Lex B., Vervoort, Jacques   +11 more
core   +3 more sources

Priming Effect Induced by the Use of Different Fertilizers on Soil Functional Diversity

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Agriculture, 2017
Agricultural practices, such as the use of fertilizers, can change the structure and function of soil microbial community. Monitoring and assessing the soil microbiota and its dynamics related to different factors can be a powerful tool for understanding
Bogdan Mihai ONICA, Roxana VIDICAN, Valentina SANDOR, Traian BRAD, Mignon SANDOR   +4 more
doaj   +1 more source

Targeting glutamine metabolism in hepatic stellate cells alleviates liver fibrosis

Cell Death and Disease, 2022
Glutamine metabolism plays an essential role in cell growth, and glutamate dehydrogenase (GDH) is a key enzyme. GDH promotes the metabolism of glutamate and glutamine to generate ATP, which is profoundly increased in multiple human cancers.
Xiaochun Yin, Jin Peng, Lihong Gu, Yan Liu, Xihan Li, Jinhui Wu, Bing Xu, Yuzheng Zhuge, Feng Zhang   +8 more
doaj   +1 more source

Lactuca sativa L. losses and wastes as a source of biobased ingredients

Journal of the Science of Food and Agriculture, Volume 106, Issue 6, Page 3577-3591, April 2026.
Abstract BACKGROUND The growing global population and increasing consumer focus on healthy eating challenge the agricultural sector to ensure both sustainable food production and safety. Lettuce (Lactuca sativa Mill.), the most cultivated leafy vegetable worldwide, can lose up to 40% of its weight during processing.
Joana PB Rodrigues, Tayse FF da Silveira, Daniele B Rodrigues, Laura Domínguez, Patricia Morales, Tânia CSP Pires, Maria Beatriz PP Oliveira, Ângela Fernandes, Lillian Barros   +8 more
wiley   +1 more source

Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies. [PDF]

, 2019
Variation in steroid hormone levels has wide implications for health and disease. The genes encoding the proteins involved in steroid disposition represent key determinants of interindividual variation in steroid levels and ultimately, their effects ...
Boerwinkle, Eric, Cheung, Kit Wun Kathy, Chien, Huan-Chieh, Feofanova, Elena V, Giacomini, Kathleen M, Irannejad, Roshanak, Kinchen, Jason M, Stecula, Adrian, Suhre, Karsten, van Borselen, Marjolein, Yee, Sook Wah, Yousri, Noha A, Yu, Bing, Zou, Ling   +13 more
core   +2 more sources