Propolis-Based Nanostructured Lipid Carriers for α-Mangostin Delivery: Formulation, Characterization, and In Vitro Antioxidant Activity Evaluation [PDF]
Molecules, 2023 α-Mangostin (a xanthone derivative found in the pericarp of Garcinia mangostana L.) and propolis extract (which is rich in flavonoids and phenols) are known for their antioxidant properties, making them potential supplements for the treatment of ...
Cecep Suhandi +6 more
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α-Mangostin, a safe and natural product as a candidate skin-whitening agent [PDF]
Scientific ReportsA-Mangostin is the predominant xanthone found in the pericarp of mangosteen. It has been scientifically proven to possess anti-proliferative and apoptotic properties against different types of human cancer cells.
Xinmei Li +4 more
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Garcinia mangostana L. Pericarp Extract and Its Active Compound α-Mangostin as Potential Inhibitors of Immune Checkpoint Programmed Death Ligand-1 [PDF]
Molecules, 2023 α-Mangostin, a major xanthone found in mangosteen (Garcinia mangostana L., Family Clusiaceae) pericarp, has been shown to exhibit anticancer effects through multiple mechanisms of action.
Sandar Naing +5 more
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Frontiers in Pharmacology, 2021 Mangostin, which has the function of anti-inflammatory, antioxidant, and anticancer, etc, is one of the main active ingredients of the hull of the mangosteen.
Xiuzhi Zhu +7 more
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Bioactivities of β-mangostin and its new glycoside derivatives synthesized by enzymatic reactions
Royal Society Open Science, 2023 Beta-mangostin is a xanthone commonly found in the genus Garcinia. Unlike α-mangostin, to date, there have only been a few studies on the biological activity and derivatization of β-mangostin.
Tuoi Thi Le, Van Thuy Thi Pham
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Potential target and mechanism exploration from α-mangostin against triple-negative breast cancer: An in silico study [PDF]
Journal of Advanced Pharmaceutical Technology & ResearchTriple-negative breast cancer (TNBC) is one of the most common types of serious breast cancer. Due to the absence of therapeutic hormone receptors, TNBC treatment generally involves chemotherapy which results in various side effects and resistance ...
Rafly Mochamad Rivaldo, Paulus Chandra
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α-Mangostin: A Xanthone Derivative in Mangosteen with Potent Anti-Cancer Properties [PDF]
Biomoleculesα-Mangostin, a xanthone derivative extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.), has garnered significant attention for its potential as a natural anti-cancer agent.
Amin F. Majdalawieh +3 more
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Unraveling the influence of α-mangostin on MDA-MB-231 cell line via WNT/β-catenin signaling pathway: in silico and in vitro approaches [PDF]
Frontiers in PharmacologyThe Wnt/β-catenin signaling pathway is critically involved in breast cancer progression, particularly in the triple-negative subtype (TNBC). Aberrant activation of this pathway promotes tumor proliferation, with β-catenin functioning as a central ...
Riezki Amalia +9 more
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α-Mangostin Exhibits Antitumor Activity Against NCI-H1975 Cells via the EGFR/STAT3 Pathway: An Experimental and Molecular Simulation Study [PDF]
MoleculesNon-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations have brought great challenges to the medical treatment in the world. Current treatment strategies, such as EGFR tyrosine kinase inhibitors (TKIs), have reached
Jing Wang +7 more
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α-Mangostin suppresses ethanol-induced gastric ulceration by regulating the Nrf2/HO-1 and NF-κB/NLRP3/caspase-1 signaling pathways and gut microbiota [PDF]
Heliyonα-Mangostin is a natural xanthone derivative isolated from Camellia atrophy (CA), commonly known as Lichuan black tea (LBT). The present study investigated the ameliorating effect and mechanism of α-mangostin on alcoholic gastric ulcers (GU) in rats.
Suqin Yang +5 more
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