Results 31 to 40 of about 1,910 (128)

α-Mangostin Induces Ca2+-ATPase-Dependent Apoptosis via Mitochondrial Pathway in PC12 Cells

Journal of Pharmacological Sciences, 2004
We investigated the cell death effects of eight xanthones on PC12 rat pheochromocytoma cells. Among these compounds, α-mangostin, from the fruit hull of Garcinia mangostana L., had the most potent effect with the EC50 value of 4 μM.
Ayumi Sato, Hironori Fujiwara, Hisae Oku, Kyoko Ishiguro, Yasushi Ohizumi   +4 more
doaj   +1 more source

Molecular Docking of Mangostin and Sinensetin Derivatives on SUR1-Pancreatic KATP Channel Target as Antidiabetic

Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2021
Background: Diabetes Mellitus (DM) is a complex chronic disease characterized by increased blood glucose. The incidence of this disease is rising, especially type 2 diabetes which is caused by insulin resistance in the body.
Intan Kris Prasetyanti, Sukardiman, Suharjono   +2 more
doaj   +1 more source

Encapsulation mechanism of α-mangostin by β-cyclodextrin: Methods of molecular docking and molecular dynamics

Journal of Advanced Pharmaceutical Technology & Research, 2021
The study aimed to investigate the interaction of host-guest between α-mangostin and β-cyclodextrin (βCD) and also to calculate the energy of the complex system between α-mangostin with βCD for drug delivery using methods of 15 molecular dynamics and ...
Dian Triwahyuningtyas, Sandra Megantara, Tai Tze Hong, Muhammad Yusuf, Muchtaridi Muchtaridi   +4 more
doaj   +1 more source

Dose-Independent ADME Properties and Tentative Identification of Metabolites of α-Mangostin from Garcinia mangostana in Mice by Automated Microsampling and UPLC-MS/MS Methods. [PDF]

PLoS ONE, 2015
The information about a marker compound's pharmacokinetics in herbal products including the characteristics of absorption, distribution, metabolism, excretion (ADME) is closely related to the efficacy/toxicity.
Seung Yon Han, Byoung Hoon You, Yu Chul Kim, Young-Won Chin, Young Hee Choi   +4 more
doaj   +1 more source

A Review on Synthetic and Pharmacological Potential of Compounds Isolated from Garcinia mangostana Linn

Phytomedicine Plus, 2022
Background: : The extracts of Garcinia mangostana (L) pericarp contain high concentration of prenylated xanthones such as α-, β- and γ-mangostin and related molecules.
Swathy Unnikrishna Pillai Saraswathy, Lekshmi Chandran Pillai Lalitha, Sherifa Rahim, Chithra Gopinath, Simimole Haleema, Sumalekshmy SarojiniAmma, Hassan Y. Aboul-Enein   +6 more
doaj   +1 more source

The Potential of α-Mangostin from Garcinia mangostana as an Effective Antimicrobial Agent—A Systematic Review and Meta-Analysis

Antibiotics, 2022
This systematic review aims to evaluate the antimicrobial activity of α-mangostin derived from Garcinia mangostana against different microbes. A literature search was performed using PubMed and Science Direct until March 2022.
Omer Sheriff Sultan, Haresh Kumar Kantilal, Suan Phaik Khoo, Amalraj Fabian Davamani, Sumaiya Zabin Eusufzai, Farah Rashid, Nafij Bin Jamayet, Jue Ann Soh, Yen Yee Tan, Mohammad Khursheed Alam   +9 more
doaj   +1 more source

Mechanisms of Rapid Bactericidal and Anti-Biofilm Alpha-Mangostin In Vitro Activity against Staphylococcus aureus

Polish Journal of Microbiology, 2023
Alpha-mangostin (α-mangostin) was discovered as a potent natural product against Gram-positive bacteria, whereas the underlying molecular mechanisms are still unclear.
Deng Xiangbin, Xu Hongbo, Li Duoyun, Chen Jinlian, Yu Zhijian, Deng Qiwen, Li Peiyu, Zheng Jinxin, Zhang Haigang   +8 more
doaj   +1 more source

KARAKTERISASI SUSPENSI NANOPARTIKEL α-MANGOSTIN BERBASIS KITOSAN SEBAGAI SISTEM PENGHANTAR OBAT

Parapemikir : Jurnal Ilmiah Farmasi
α-Mangostin (αM) merupakan senyawa xanton bioaktif utama yang berasal dari Garcinia mangostana L. dan diketahui memiliki berbagai aktivitas farmakologis, seperti antioksidan, antiinflamasi, dan antimikroba. Namun, pemanfaatan αM secara topikal maupun oral masih terbatas akibat ketidakstabilan dan kelarutannya yang rendah dalam media berair, sehingga
Kusnadi Kusnadi, Muladi Putra Mahardika
openaire   +1 more source

Garcinone C Suppresses Cancer Stem Cells and Induces Apoptosis in Triple‐Negative Breast Cancer Through Canonical Wnt Signaling

Food Frontiers, Volume 7, Issue 3, May 2026.
Garcinone C (Gar. C), a xanthone derived from mangosteen (Garcinia mangostana), suppresses triple‐negative breast cancer growth and stemness by inducing mitochondrial‐mediated apoptosis and inhibiting the Wnt/β‐catenin pathway, highlighting its potential as a natural compound for the prevention and treatment TNBC.
Danhong Zheng, Jiazi Chen, Yong Wang, Da Ma, Jing Chen   +4 more
wiley   +1 more source

Targeting Tumor Stroma: Current Challenges and Future Directions

MedComm, Volume 7, Issue 5, May 2026.
Figure 1. Mechanism of ECM reprogramming. Cancer‐associated fibroblasts (CAFs), cancer‐associated macrophages (CAMs), and other mesenchymal cells alter the ECM composition and increase its stiffness by depositing matrix components such as collagen and hyaluronic acid, and secreting cross‐linking agents like lysyl oxidase homolog 2 (LOXL2).
Siwei Wang, Haofan Hu, Weifeng Zeng, Lu Qin, Xiaoping Chen, Zhibin Liao, Furong Liu, Zhanguo Zhang   +7 more
wiley   +1 more source