Results 21 to 30 of about 993,255 (173)

α-Mangostin Exhibits Antitumor Activity Against NCI-H1975 Cells via the EGFR/STAT3 Pathway: An Experimental and Molecular Simulation Study [PDF]

Molecules
Non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations have brought great challenges to the medical treatment in the world. Current treatment strategies, such as EGFR tyrosine kinase inhibitors (TKIs), have reached
Jing Wang, Jiamin Xian, Ruohan Zhang, Zhuoyi Wang, Shuanggou Zhang, Die Zhao, Jun Sheng, Peiyuan Sun   +7 more
doaj   +2 more sources

Inhibitory effects of α-Mangostin on T cell cytokine secretion via ORAI1 calcium channel and K+ channels inhibition [PDF]

PeerJ, 2021
Background As one of the main components of mangosteen (Garcinia mangostana), a tropical fruit, α-mangostin has been reported to have numerous pharmacological benefits such as anti-cancer, anti-inflammatory, and anti-allergic effects through various ...
Hyun Jong Kim, Seorin Park, Hui Young Shin, Yu Ran Nam, Phan Thi Lam Hong, Young-Won Chin, Joo Hyun Nam, Woo Kyung Kim   +7 more
doaj   +2 more sources

α-Mangostin Induces Apoptosis in Human Osteosarcoma Cells Through ROS-Mediated Endoplasmic Reticulum Stress via the WNT Pathway

Cell Transplantation, 2021
α-mangostin has been confirmed to promote the apoptosis of MG-63 cells, but its specific pro-apoptosis mechanism in osteosarcoma (OS) remains further investigation.
Shengsen Yang, Fei Zhou, Yi Dong, Fei Ren   +3 more
doaj   +1 more source

Alpha-mangostin inhibits the migration and invasion of A549 lung cancer cells [PDF]

PeerJ, 2018
Several studies have indicated that α-mangostin exerts anti-metastasis and anti-subsistence effects on several types of cancer cells. Especially, the anti-metastatic effect of α-mangostin on cancer cells is a prospective function in cancer treatment ...
Thi Kieu Trang Phan, Fahimeh Shahbazzadeh, Thi Thu Huong Pham, Takanori Kihara   +3 more
doaj   +2 more sources

Alpha-Mangostin-Loaded Transferrin-Conjugated Lipid-Polymer Hybrid Nanoparticles: Development and Characterization for Tumor-Targeted Delivery

The Scientific World Journal, 2022
Alpha-mangostin, a natural xanthone mainly extracted from the pericarp of Garcinia mangostana, has been shown to have promising anticancer properties in many types of cancer.
Intouch Sakpakdeejaroen, Patcharaporn Muanrit, Sumalee Panthong, Srisopa Ruangnoo   +3 more
doaj   +1 more source

3,6-dimethyl ester-α-mangostin Compound Modified from Isolate α-mangostin Garcinia Mangostana Linn [PDF]

, 2021
Isolate α-mangostin (1) is a phenolic compound derived from oxygenated and prenylated xanthones and major compounds obtained from the fruit peel of G. mangostana Linn., Which is stated to have inhibitory activity against α-glucosidase enzymes, serves to ...
Ersam, Taslim; Department of Chemistry, Institut Teknologi Sepuluh Nopember, Umami, Khoiriyah; Department of Chemistry, Institut Teknologi Sepuluh Nopember, Fadlan, Arif; Department of Chemistry, Institut Teknologi Sepuluh Nopember, Taslim Ersam, Khoiriyah Umami, Arif Fadlan   +5 more
core   +1 more source

α-Mangostin induces apoptosis and suppresses differentiation of 3T3-L1 cells via inhibiting fatty acid synthase. [PDF]

PLoS ONE, 2012
α-Mangostin, isolated from the hulls of Garcinia mangostana L., was found to have in vitro cytotoxicity against 3T3-L1 cells as well as inhibiting fatty acid synthase (FAS, EC 2.3.1.85). Our studies showed that the cytotoxicity of α-mangostin with IC(50)
Xiaofang Quan, Yi Wang, Xiaofeng Ma, Yan Liang, Weixi Tian, Qingyun Ma, Hezhong Jiang, Youxing Zhao   +7 more
doaj   +1 more source

Garcinia mangostana L. Pericarp Extract and Its Active Compound α-Mangostin as Potential Inhibitors of Immune Checkpoint Programmed Death Ligand-1

Molecules, 2023
α-Mangostin, a major xanthone found in mangosteen (Garcinia mangostana L., Family Clusiaceae) pericarp, has been shown to exhibit anticancer effects through multiple mechanisms of action.
Sandar Naing, Nichawadee Sandech, Arnatchai Maiuthed, Sumet Chongruchiroj, Jaturong Pratuangdejkul, Pattamapan Lomarat   +5 more
doaj   +1 more source

Pengaruh Metode Isolasi a-mangostin dari Kulit Buah Manggis (Garcinia mangostana L.) terhadap Rendemen α-mangostin

Jurnal Penelitian Pendidikan IPA, 2019
Abstract: The purpose of this research is to know the effect of the isolation method of the yield of α-mangostin resulting from mangosteen rind. Mangosteen (Garcinia mangostana L.) is the source of xanthone secondary metabolites. Derivatives xanthone which is the main bioactive compound and becomes a major compound in the mangosteen plant, namely α ...
Idawati, Sri, Hakim, Aliefman, Andayani, Yayuk   +2 more
openaire   +2 more sources

α-Mangostin inhibits LPS-induced bone resorption by restricting osteoclastogenesis via NF-κB and MAPK signaling

Chinese Medicine, 2022
Background Excessive osteoclast activation is an important cause of imbalanced bone remodeling that leads to pathological bone destruction. This is a clear feature of many osteolytic diseases such as rheumatoid arthritis, osteoporosis, and osteolysis ...
Wenkan Zhang, Guangyao Jiang, Xiaozhong Zhou, Leyi Huang, Jiahong Meng, Bin He, Yiying Qi   +6 more
doaj   +1 more source