Results 21 to 30 of about 3,668 (172)

α-Mangostin Extraction from the Native Mangosteen (Garcinia mangostana L.) and the Binding Mechanisms of α-Mangostin to HSA or TRF. [PDF]

PLoS ONE, 2016
In order to obtain the biological active compound, α-mangostin, from the traditional native mangosteen (Garcinia mangostana L.), an extraction method for industrial application was explored.
Ming Guo, Xiaomeng Wang, Xiaowang Lu, Hongzheng Wang, Peter E Brodelius   +4 more
doaj   +1 more source

Alpha-Mangostin-Loaded Transferrin-Conjugated Lipid-Polymer Hybrid Nanoparticles: Development and Characterization for Tumor-Targeted Delivery

The Scientific World Journal, 2022
Alpha-mangostin, a natural xanthone mainly extracted from the pericarp of Garcinia mangostana, has been shown to have promising anticancer properties in many types of cancer.
Intouch Sakpakdeejaroen, Patcharaporn Muanrit, Sumalee Panthong, Srisopa Ruangnoo   +3 more
doaj   +1 more source

α-Mangostin induces apoptosis and suppresses differentiation of 3T3-L1 cells via inhibiting fatty acid synthase. [PDF]

PLoS ONE, 2012
α-Mangostin, isolated from the hulls of Garcinia mangostana L., was found to have in vitro cytotoxicity against 3T3-L1 cells as well as inhibiting fatty acid synthase (FAS, EC 2.3.1.85). Our studies showed that the cytotoxicity of α-mangostin with IC(50)
Xiaofang Quan, Yi Wang, Xiaofeng Ma, Yan Liang, Weixi Tian, Qingyun Ma, Hezhong Jiang, Youxing Zhao   +7 more
doaj   +1 more source

Nanoformulations of α-Mangostin for Cancer Drug Delivery System

Pharmaceutics, 2021
Natural compounds are emerging as effective agents for the treatment of malignant diseases. The active constituent of α-mangostin from the pericarp of Garcinia mangostana L.
Lisna Meylina, Muchtaridi Muchtaridi, I Made Joni, Ahmed Fouad Abdelwahab Mohammed, Nasrul Wathoni   +4 more
doaj   +1 more source

α-mangostin improves glucose uptake and inhibits adipocytes differentiation in 3T3-L1 cells via PPARgamma, GLUT4, and leptin expressions [PDF]

, 2015
Obesity has been often associated with the occurrence of cardiovascular diseases, type 2 diabetes, and cancer. The development of obesity is also accompanied by significant differentiation of preadipocytes into adipocytes.
Ahmed, Qamar Uddin, Deny Susanti,, Jauhari Arief Ichwan, Solachuddin, Kaderi, Mohd Arifin, Mohamed Amiroudine, Mohamed Zaffar Ali, Taher, Muhammad, Tengku Zakaria, Tengku Muhamad Faris Syafiq, Zakaria, Zainul Amiruddin   +7 more
core   +5 more sources

α-Mangostin inhibits LPS-induced bone resorption by restricting osteoclastogenesis via NF-κB and MAPK signaling

Chinese Medicine, 2022
Background Excessive osteoclast activation is an important cause of imbalanced bone remodeling that leads to pathological bone destruction. This is a clear feature of many osteolytic diseases such as rheumatoid arthritis, osteoporosis, and osteolysis ...
Wenkan Zhang, Guangyao Jiang, Xiaozhong Zhou, Leyi Huang, Jiahong Meng, Bin He, Yiying Qi   +6 more
doaj   +1 more source

Molecular docking studies of α-mangostin, γ-mangostin, and xanthone on peroxisome proliferator-activated receptor gamma diphenyl peptidase-4 enzyme, and aldose reductase enzyme as an antidiabetic drug candidate

Journal of Advanced Pharmaceutical Technology & Research, 2021
α-mangostin, γ-mangostin, and xanthone are some of the marker compounds found in mangosteen (Garcinia mangostana Linn.) whose activity on several treatment targets including toward the peroxisome proliferator-activated receptor gamma (PPAR-γ) receptors ...
Rifa'atul Mahmudah, I Ketut Adnyana, Elin Yulinah Sukandar   +2 more
doaj   +1 more source

Honokiol and Alpha-Mangostin Inhibit Mayaro Virus Replication through Different Mechanisms

Molecules, 2022
Mayaro virus (MAYV) is an emerging arbovirus with an increasing circulation across the Americas. In the present study, we evaluated the potential antiviral activity of the following natural compounds against MAYV and other arboviruses: Sanguinarine, (R ...
Patricia Valdés-Torres, Dalkiria Campos, Madhvi Bhakta, Paola Elaine Galán-Jurado, Armando A. Durant-Archibold, José González-Santamaría   +5 more
doaj   +1 more source

Molecular Docking of Mangostin and Sinensetin Derivatives on SUR1-Pancreatic KATP Channel Target as Antidiabetic

Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2021
Background: Diabetes Mellitus (DM) is a complex chronic disease characterized by increased blood glucose. The incidence of this disease is rising, especially type 2 diabetes which is caused by insulin resistance in the body.
Intan Kris Prasetyanti, Sukardiman, Suharjono   +2 more
doaj   +1 more source

α-Mangostin Induces Ca2+-ATPase-Dependent Apoptosis via Mitochondrial Pathway in PC12 Cells

Journal of Pharmacological Sciences, 2004
We investigated the cell death effects of eight xanthones on PC12 rat pheochromocytoma cells. Among these compounds, α-mangostin, from the fruit hull of Garcinia mangostana L., had the most potent effect with the EC50 value of 4 μM.
Ayumi Sato, Hironori Fujiwara, Hisae Oku, Kyoko Ishiguro, Yasushi Ohizumi   +4 more
doaj   +1 more source