Results 11 to 20 of about 993,255 (173)

α-Mangostin Competing the Menaquinone-Binding Sites of NDH-2 to Block the Electron Transfer at the Quinone Pool of Staphylococcus aureus [PDF]

Antibiotics
Background/Objectives: α-Mangostin, a natural product from Garcinia mangostana L, presents very strong antibacterial activity in plant flavonoids against Staphylococcus aureus.
Meifang Zhang, Jianing Hu, Yu Wang, Liaolongyan Luo, Ganjun Yuan   +4 more
doaj   +2 more sources

Penambatan Molekuler α, β, dan γ-mangostin Sebagai Inhibitor α-amilase Pankreas Manusia [PDF]

Indonesian Journal of Chemical Research, 2019
In silico studies on interactions between the human pancreatic α-amylase (HPA) enzyme with α, β, and γ-mangostin ligands has been carried out using the molecular docking method. Ligands α, β, and γ-mangostin interact through the formation of hydrogen and
Nelson Gaspersz, Mario Rowan Sohilait
doaj   +2 more sources

Nanoformulations of α-Mangostin for Cancer Drug Delivery System

Pharmaceutics, 2021
Natural compounds are emerging as effective agents for the treatment of malignant diseases. The active constituent of α-mangostin from the pericarp of Garcinia mangostana L.
Lisna Meylina, Muchtaridi Muchtaridi, I Made Joni, Ahmed Fouad Abdelwahab Mohammed, Nasrul Wathoni   +4 more
doaj   +2 more sources

α-Mangostin, a safe and natural product as a candidate skin-whitening agent [PDF]

Scientific Reports
A-Mangostin is the predominant xanthone found in the pericarp of mangosteen. It has been scientifically proven to possess anti-proliferative and apoptotic properties against different types of human cancer cells.
Xinmei Li, Xinyu Zhu, Bingqian Wang, Jiaming Sun, Yun Xia   +4 more
doaj   +2 more sources

α-Mangostin-phytosomes as a plausible nano-vesicular approach for enhancing cytotoxic activity on SKOV-3 ovarian cancer cells

Future Journal of Pharmaceutical Sciences
Background α-Mangostin is a major xanthone in Garcinia mangostana L. (Clusiaceae) pericarps. It has promising anti-proliferative potential in different cancer cells; however, it has poor oral bioavailability.
Abdulmohsin J. Alamoudi, Shaimaa M. Badr-Eldin, Osama A. A. Ahmed, Serag Eldin I. Elbehairi, Mohammad Y. Alfaifi, Hani Z. Asfour, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Ashraf B. Abdel-Naim, Hossam M. Abdallah   +9 more
doaj   +2 more sources

Potential target and mechanism exploration from α-mangostin against triple-negative breast cancer: An in silico study [PDF]

Journal of Advanced Pharmaceutical Technology & Research
Triple-negative breast cancer (TNBC) is one of the most common types of serious breast cancer. Due to the absence of therapeutic hormone receptors, TNBC treatment generally involves chemotherapy which results in various side effects and resistance ...
Rafly Mochamad Rivaldo, Paulus Chandra
doaj   +2 more sources

α-Mangostin: A Xanthone Derivative in Mangosteen with Potent Anti-Cancer Properties [PDF]

Biomolecules
α-Mangostin, a xanthone derivative extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.), has garnered significant attention for its potential as a natural anti-cancer agent.
Amin F. Majdalawieh, Tala M. Terro, Sogand H. Ahari, Imad A. Abu-Yousef   +3 more
doaj   +2 more sources

Evaluation of the antibacterial activity of the natural product α-mangostin against Clostridioides difficile. [PDF]

PLoS ONE
Clostridioides difficile is the leading cause of hospital-associated diarrhea and has remained a consistent threat for older patients and those with comorbidities or vulnerabilities.
Brice J Stolz, Ahmed Abouelkhair, Nader S Abutaleb, Mohamed N Seleem   +3 more
doaj   +2 more sources

α-Mangostin Enhances Betulinic Acid Cytotoxicity and Inhibits Cisplatin Cytotoxicity on HCT 116 Colorectal Carcinoma Cells

Molecules, 2012
Despite the progress in colon cancer treatment, relapse is still a major obstacle. Hence, new drugs or drug combinations are required in the battle against colon cancer.
Amin Malik Shah Abdul Majid, Zhari Ismail, Khalid M. Abu-Salah, Abdalrahim F. A. Aisha   +3 more
doaj   +2 more sources

Unraveling the influence of α-mangostin on MDA-MB-231 cell line via WNT/β-catenin signaling pathway: in silico and in vitro approaches [PDF]

Frontiers in Pharmacology
The Wnt/β-catenin signaling pathway is critically involved in breast cancer progression, particularly in the triple-negative subtype (TNBC). Aberrant activation of this pathway promotes tumor proliferation, with β-catenin functioning as a central ...
Riezki Amalia, Riezki Amalia, Citra Dewi, Citra Dewi, Citra Dewi, Adryan Fristiohady, Taufik Muhammad Fakih, Taufik Muhammad Fakih, Muchtaridi Muchtaridi, Muchtaridi Muchtaridi   +9 more
doaj   +2 more sources