Results 51 to 60 of about 1,910 (128)

Identification of Anti‐Inflammatory and Analgesic Mechanisms of Naru‐3 Wei Pill Using Animal Models, UHPLC‐QE‐MS, and Integrated Network Pharmacology

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Background Naru‐3 Wei Pill is a traditional Mongolian Medicine (TMM) that has anti‐inflammatory, analgesic, and antibacterial effects. The present study aimed to demonstrate the anti‐inflammatory and analgesic effect of Naru‐3 Wei Pill, identify the core components and key targets and determine the pharmacological basis and mechanism of its blood‐borne
Zhiqiang Han, Husile Kang, Aidi Zhang, Qigeqin, Baolechaolu, Wulanqiqige, Huan Wang, Yanhua Xu, HaSi, Anda, Lan Xue, K. Sony Reddy   +11 more
wiley   +1 more source

Exploring gastroprotective effect and mechanisms of epigallocatechin gallate‐impregnated black garlic in acidic ethanol‐induced gastric ulcer model mice

Journal of the Science of Food and Agriculture, Volume 105, Issue 15, Page 8717-8732, December 2025.
Abstract Background Peptic ulcers, particularly gastric ulcers (GUs), are multifactorial disorders with unclear mechanisms. Black garlic (BG) has shown gastroprotective effects. This study evaluated the effects of BG and epigallocatechin gallate‐impregnated BG (EG) in acidic ethanol (AE)‐induced GU model mice. Mice were pretreated with BG or EG (50–200 
Ming‐Shiun Tsai, Gunn‐Guang Liou, Chang‐Wei Hsieh, Jiunn‐Wang Liao, Pin‐Yen Lai, Chao‐Kai Chang, Wan‐Jou Lee, Sue‐Hong Wang   +7 more
wiley   +1 more source

α-Mangostin-phytosomes as a plausible nano-vesicular approach for enhancing cytotoxic activity on SKOV-3 ovarian cancer cells

Future Journal of Pharmaceutical Sciences
Background α-Mangostin is a major xanthone in Garcinia mangostana L. (Clusiaceae) pericarps. It has promising anti-proliferative potential in different cancer cells; however, it has poor oral bioavailability.
Abdulmohsin J. Alamoudi, Shaimaa M. Badr-Eldin, Osama A. A. Ahmed, Serag Eldin I. Elbehairi, Mohammad Y. Alfaifi, Hani Z. Asfour, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Ashraf B. Abdel-Naim, Hossam M. Abdallah   +9 more
doaj   +1 more source

Oral Delivery of Semaglutide and Tirzepatide Using Milk‐Derived Small Extracellular Vesicles

Journal of Extracellular Biology, Volume 4, Issue 11, November 2025.
ABSTRACT Therapeutic proteins and peptides have revolutionized modern biomedicine, but their oral delivery is limited by gastrointestinal degradation and barriers. Small extracellular vesicles (sEVs), which are resistant to biochemical degradation and capable of traversing mucus and cellular barriers, hold great promise as next‐generation oral delivery
Yuefei Zhang, Jianyi Han, Wei Wu, Bobo Dang   +3 more
wiley   +1 more source

Inhibitory Effect of Alpha-Mangostin to Dengue Virus Replication and Cytokines Expression in Human Peripheral Blood Mononuclear Cells

Natural Products and Bioprospecting, 2019
Massive pro-inflammatory cytokines production has been correlated with the pathogenesis of severe dengue disease. The active compound of mangosteen fruit pericarps, α-mangostin, has been commonly used as traditional medicine and dietary supplement.
Zaenal Sugiyanto, Benediktus Yohan, Soeharyo Hadisaputro, Edi Dharmana, Catharina Suharti, Winarto, Kis Djamiatun, Fifin L. Rahmi, R. Tedjo Sasmono   +8 more
doaj   +1 more source

In vitro and in vivo studies reveal α-Mangostin, a xanthonoid from Garcinia mangostana, as a promising natural antiviral compound against chikungunya virus

Virology Journal, 2021
Background Chikungunya virus (CHIKV), a serious health problem in several tropical countries, is the causative agent of chikungunya fever. Approved antiviral therapies or vaccines for the treatment or prevention of CHIKV infections are not available.
Poonam Patil, Megha Agrawal, Shahdab Almelkar, Manish Kumar Jeengar, Ashwini More, Kalichamy Alagarasu, Naveen V. Kumar, Prathama S. Mainkar, Deepti Parashar, Sarah Cherian   +9 more
doaj   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, Volume 37, Issue 42, October 23, 2025.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD VALIDATION OF α-MANGOSTIN ASSAY IN MANGOSTEEN (Garcinia mangostana L.) FRUIT RIND EXTRACT FORMULATED IN ORAL SOLUTION

Alchemy, 2015
Mangosteen fruit rind extract contain a lot of antioxidants. α-Mangostin is a component in mangosteen fruit rind that has highest antioxidant effect.
Liliek Nurhidayati, Siti Sofiah, Ros Sumarny, Kevin Caesar   +3 more
doaj   +1 more source

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

Cell Proliferation, Volume 58, Issue 10, October 2025.
Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su, Yanlin Li, Zihao Zhou, Bing Feng, Haiming Chen, Guangjuan Zheng   +5 more
wiley   +1 more source

The α-mangostin effect on the quantity of TGF-β1 titer relate to the mandibular bone volume of Rattus novergicus in the periodontitis model [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2021
Context: Periodontitis causes pocket formation, gingival recession, and destruction of periodontal ligaments and alveolar bone. Periodontitis disturbs the attachment of periodontal ligaments to the maxillary and mandibular bones.
Citra Lestari, Eryati Darwin, Deddi Prima Putra, Netti Suharti   +3 more
doaj