Results 71 to 80 of about 3,668 (172)

In vitro assessment of anti-proliferative effect induced by α-mangostin from Cratoxylum arborescens on HeLa cells [PDF]

, 2017
Natural medicinal products possess diverse chemical structures and have been an essential source for drug discovery. Therefore, in this study, α-mangostin (AM) is a plant-derived compound was investigated for the apoptotic effect on human cervical cancer
El Habbash, A. I., Elmutaal Omer, F. A., Hashim, N. M., Ibrahim, M. Y., Lian, G. E. C., Nordin, N., Rahman, M. A., Yahayu, M.   +7 more
core  

Oral Delivery of Semaglutide and Tirzepatide Using Milk‐Derived Small Extracellular Vesicles

Journal of Extracellular Biology, Volume 4, Issue 11, November 2025.
ABSTRACT Therapeutic proteins and peptides have revolutionized modern biomedicine, but their oral delivery is limited by gastrointestinal degradation and barriers. Small extracellular vesicles (sEVs), which are resistant to biochemical degradation and capable of traversing mucus and cellular barriers, hold great promise as next‐generation oral delivery
Yuefei Zhang, Jianyi Han, Wei Wu, Bobo Dang   +3 more
wiley   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, Volume 37, Issue 42, October 23, 2025.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD VALIDATION OF α-MANGOSTIN ASSAY IN MANGOSTEEN (Garcinia mangostana L.) FRUIT RIND EXTRACT FORMULATED IN ORAL SOLUTION

Alchemy, 2015
Mangosteen fruit rind extract contain a lot of antioxidants. α-Mangostin is a component in mangosteen fruit rind that has highest antioxidant effect.
Liliek Nurhidayati, Siti Sofiah, Ros Sumarny, Kevin Caesar   +3 more
doaj   +1 more source

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

Cell Proliferation, Volume 58, Issue 10, October 2025.
Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su, Yanlin Li, Zihao Zhou, Bing Feng, Haiming Chen, Guangjuan Zheng   +5 more
wiley   +1 more source

α-Mangostin-phytosomes as a plausible nano-vesicular approach for enhancing cytotoxic activity on SKOV-3 ovarian cancer cells

Future Journal of Pharmaceutical Sciences
Background α-Mangostin is a major xanthone in Garcinia mangostana L. (Clusiaceae) pericarps. It has promising anti-proliferative potential in different cancer cells; however, it has poor oral bioavailability.
Abdulmohsin J. Alamoudi, Shaimaa M. Badr-Eldin, Osama A. A. Ahmed, Serag Eldin I. Elbehairi, Mohammad Y. Alfaifi, Hani Z. Asfour, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Ashraf B. Abdel-Naim, Hossam M. Abdallah   +9 more
doaj   +1 more source

Uji Aktivitas Antimalaria In Vivo dari Beberapa Fraksi Ekstrak Kulit Buah Manggis (Garcinia Manggostana Linn) pada Mencit (Mus Musculus ) yang Diinfeksi dengan Plasmodium Berghei [PDF]

, 2013
Malaria disease is still one public health problem in the world and affect the infant mortality rate, under five and pregnant women. The purpose of this study was to recognize in vivo antimalarial activity from hexane fraction, ethyl acetate, and ...
Aamruna, Y. (Yaum), Effendi, Z. (Zulham), Iqbal, M. (Muhammad), Suryawati, S. (Suryawati)   +3 more
core  

Modulating Macrophage–Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration

Advanced Science, Volume 12, Issue 36, September 25, 2025.
The G‐CS/MSN drug delivery system enhances intervertebral disc repair through sequential drug release. Abstract Intervertebral disc degeneration (IDD) is characterized by an inflammatory environment and dysregulation of the extracellular matrix metabolism (ECM).
Xiangzhen Kong, Rui Hu, Peng Zhang, Qi Li, Kangle Song, Hanwen Gu, Jihui Zheng, Shen Liu, Liang Liu, Lin Jin, Lei Cheng, Chengwei Li, Zhijian Wei   +12 more
wiley   +1 more source

Impact of Alpha-mangostin on human esophageal adenocarcinoma cells reveals activation of key apoptotic signaling pathways

Discover Oncology
Current chemotherapeutic modalities for the clinical management of esophageal adenocarcinoma, do not, in most cases, result in complete remission and also elicit adverse side effects.
Cecille Canary, Ketki Patil, Vania M. Dominick, Cristina Quintero, Mauricio Rojas, Mitchell Barnes, S. Balakrishna Pai   +6 more
doaj   +1 more source

α-Mangostin Enhances Betulinic Acid Cytotoxicity and Inhibits Cisplatin Cytotoxicity on HCT 116 Colorectal Carcinoma Cells

Molecules, 2012
Despite the progress in colon cancer treatment, relapse is still a major obstacle. Hence, new drugs or drug combinations are required in the battle against colon cancer.
Amin Malik Shah Abdul Majid, Zhari Ismail, Khalid M. Abu-Salah, Abdalrahim F. A. Aisha   +3 more
doaj   +1 more source