Results 151 to 160 of about 50,470 (216)

Addressing the Challenges of Translating LRRK2 Biology into Disease‐Modifying Therapies: The LRRK2 Investigative Therapeutics Exchange Initiative

Movement Disorders, EarlyView.
Esther Sammler, Francesca Tonelli, Michelle Durborow, Jim McNasby, Todd Sherer, Mahmood Ahmed, Stevan W. Djuric, Kalpana Merchant, Alastair Reith, Darryle Schoepp, Christine Klein, Shalini Padmanabhan, Dario R. Alessi   +12 more
wiley   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Characterization of patients with isolated REM sleep behavior disorder and cerebrospinal fluid α-synuclein negativity. [PDF]

NPJ Parkinsons Dis
Farfán F, Mammana A, Maya G, Ticca A, Montini A, Magliocchetti F, Muñoz-Lopetegi A, Vittoriosi E, Serradell M, Mastrangelo A, Arqueros A, Mariño N, Niñerola-Baizán A, Perissinotti A, Gaig C, Parchi P, Iranzo A.   +16 more
europepmc   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Early Amyloid Formation and Neuroinflammatory Response in a Bigenic Mouse Model Expressing Human α-Synuclein and Aβ. [PDF]

Parkinsons Dis
Thakore R, Aldén M, Gustavsson N, Danielson L, Lins L, Sánchez JD, Arensburg AR, Paulus A, da Silva IAN, Skoryk V, Kayed R, Gouras GK, Deierborg T, Heuer A, Konings SC, Klementieva O.   +15 more
europepmc   +1 more source

Dysregulated TIE‐2 expression is associated with blood‐brain barrier leakiness and Alzheimer's disease‐related neuropathology

Brain Pathology, EarlyView.
Ince et al., have analysed TIE‐1 and ‐2 expression in human brain tissue, including microvessel‐enriched fractions (MVF) and covering a spectrum of AD‐associated pathology, and in CSF from independent cohorts spanning a clinical spectrum from normal cognition to AD.
Selvi Ince, Carol Van Hulle, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Carey Gleason, Barbara B. Bendlin, Ozioma Okonkwo, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Sterling C. Johnson, Seth Love, J. Scott Miners   +12 more
wiley   +1 more source

Current Status of α-Synuclein Biomarkers and the Need for α-Synuclein PET Tracers. [PDF]

Cells
Berman SE, Siderowf AD.
europepmc   +1 more source

CRYAB is compromised in pathologically affected oligodendrocytes in multiple system atrophy

Brain Pathology, EarlyView.
CRYAB is hypermethylated and colocalizes with α‐synuclein in multiple system atrophy oligodendrocytes.
Finula I. Isik, Jen‐Hsiang T. Hsiao, Felicia Xaveria Suteja, Shrey Shahdadpuri, Nicolas Dzamko, Glenda M. Halliday, Woojin Scott Kim, YuHong Fu   +7 more
wiley   +1 more source

Authentic Phosphorylation of α-Synuclein at Ser129 Reveals Functional Differences Not Captured by the S129D Phosphomimetic. [PDF]

ACS Chem Biol
Allen SG, Williams C, Crump MP, Williams RJ, Mason JM.   +4 more
europepmc   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source